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Literature summary for 1.1.1.88 extracted from

  • Hedl, M.; Rodwell, V.W.
    Inhibition of the Class II HMG-CoA reductase of Pseudomonas mevalonii (2004), Protein Sci., 13, 1693-1697.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxy-3-methylglutarate
-
Pseudomonas mevalonii
4-hydroxybutyrate
-
Pseudomonas mevalonii
acetoacetate
-
Pseudomonas mevalonii
beta-hydroxybutyrate
-
Pseudomonas mevalonii
lovastin
-
Pseudomonas mevalonii
mevalonate
-
Pseudomonas mevalonii

Organism

Organism UniProt Comment Textmining
Pseudomonas mevalonii
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ There are two classes of enzyme, the third enzyme of the mevalonate pathway of isopentenyl diphosphate biosynthesis: the class I enzymes of eukaryotes and the class II enzymes of certain eubacteria Pseudomonas mevalonii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methylglutaryl-CoA + NADH + H+
-
Pseudomonas mevalonii mevalonate + CoA + NAD+
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pseudomonas mevalonii
NADH
-
Pseudomonas mevalonii

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.26
-
mevalonate standard conditions, substrate inhibition Pseudomonas mevalonii
0.28
-
lovastin competive inhibition with respect to mevanolate Pseudomonas mevalonii
0.53
-
lovastin competive inhibition with respect to 3-hydroxy-3-methylglutaryl-CoA Pseudomonas mevalonii
0.8
-
beta-hydroxybutyrate standard conditions, inhibition by substrate analog Pseudomonas mevalonii
3
-
acetoacetate standard conditions, inhibition by substrate analog Pseudomonas mevalonii
4.5
-
3-hydroxy-3-methylglutarate standard conditions, inhibition by substrate analog Pseudomonas mevalonii
16
-
lovastin non-competive inhibition with respect to NADH Pseudomonas mevalonii
35
-
lovastin non-competive inhibition with respect to NAD+ Pseudomonas mevalonii
35
-
4-hydroxybutyrate standard conditions, inhibition by substrate analog Pseudomonas mevalonii