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Literature summary for 1.1.1.88 extracted from

  • Crane, Y.M.; Korth, K.L.
    Regulated accumulation of 3-hydroxy-3-methylglutaryl CoA reductase protein in potato cell cultures: Effects of calcium and enzyme inhibitors (2002), J. Plant Physiol., 159, 1301-1307.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
EGTA EGTA causes an increase in levels of enzyme observed on immunoplots Solanum tuberosum
mevastatin The increased accumulation of the enzyme-FLAG using the open-ring form and the closed-ring form of mevastatin is observed. The mevastatin-induced enzyme increases are possibly explained by the inhibition of a feedback-regulated down-regulation due to lowered pools of mevalonate or its product Solanum tuberosum

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ the addition of Ca2+ leads to a decrease in protein accumulation Solanum tuberosum
mevalonate the addition of reaction product results in a dramatic loss of immunoreactive enzyme Solanum tuberosum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Solanum tuberosum The biosynthetic pathway leading to plant cytosolic isoprenoids begins with the 3-hydroxy-3-methyl-glutaryl CoA reductase-mediated production of mevalonate ?
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?

Organism

Organism UniProt Comment Textmining
Solanum tuberosum
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a transgenic potato cell culture system expressing an epitope-tagged enzyme
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+
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Solanum tuberosum mevalonate + CoA + NAD+
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?
additional information The biosynthetic pathway leading to plant cytosolic isoprenoids begins with the 3-hydroxy-3-methyl-glutaryl CoA reductase-mediated production of mevalonate Solanum tuberosum ?
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
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Solanum tuberosum