Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EGTA | EGTA causes an increase in levels of enzyme observed on immunoplots | Solanum tuberosum | |
mevastatin | The increased accumulation of the enzyme-FLAG using the open-ring form and the closed-ring form of mevastatin is observed. The mevastatin-induced enzyme increases are possibly explained by the inhibition of a feedback-regulated down-regulation due to lowered pools of mevalonate or its product | Solanum tuberosum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the addition of Ca2+ leads to a decrease in protein accumulation | Solanum tuberosum | |
mevalonate | the addition of reaction product results in a dramatic loss of immunoreactive enzyme | Solanum tuberosum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Solanum tuberosum | The biosynthetic pathway leading to plant cytosolic isoprenoids begins with the 3-hydroxy-3-methyl-glutaryl CoA reductase-mediated production of mevalonate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Solanum tuberosum | - |
a transgenic potato cell culture system expressing an epitope-tagged enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+ | - |
Solanum tuberosum | mevalonate + CoA + NAD+ | - |
? | |
additional information | The biosynthetic pathway leading to plant cytosolic isoprenoids begins with the 3-hydroxy-3-methyl-glutaryl CoA reductase-mediated production of mevalonate | Solanum tuberosum | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Solanum tuberosum |