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Literature summary for 1.1.1.88 extracted from

  • Ayora-Talavera, T.; Chappell, J.; Lozoya-Gloria, E.; Loyola-Vargas, V.M.
    Overexpression in Catharanthus roseus hairy roots of a truncated hamster 3-hydroxy-3-methylglutaryl-CoA reductase gene (2002), Appl. Biochem. Biotechnol., 97, 135-145.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Catharanthus roseus, the hairy roots with higher levels of soluble enzyme, clone 19, have a lower alkaloid and higher sterol content. By contrast, the clone with nonsoluble enzyme activity, clone 236, has a higher alkaloid and lower sterol content Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+ Mesocricetus auratus mevalonate pathway mevalonate + CoA + NAD+
-
?
additional information Mesocricetus auratus The enzyme can play a role in indole alkaloid biosynthesis and a possible cosuppression of both the endogenous and foreign enzyme genes in clone 236 ?
-
?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+
-
Mesocricetus auratus mevalonate + CoA + NAD+
-
?
3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+ mevalonate pathway Mesocricetus auratus mevalonate + CoA + NAD+
-
?
additional information The enzyme can play a role in indole alkaloid biosynthesis and a possible cosuppression of both the endogenous and foreign enzyme genes in clone 236 Mesocricetus auratus ?
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mesocricetus auratus
NADH
-
Mesocricetus auratus