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Literature summary for 1.1.1.88 extracted from

  • Sato, R.; Goldstein, J.L.; Brown, M.S.
    Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion (1993), Proc. Natl. Acad. Sci. USA, 90, 9261-9265.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-M6a, monkey Mesocricetus auratus
expressed in UT-2, CHO-cells Mesocricetus auratus

Protein Variants

Protein Variants Comment Organism
S871A 150% of wild-type activity in 50 mM KCl Mesocricetus auratus

General Stability

General Stability Organism
stable to quick freezing and boiling Mesocricetus auratus

Inhibitors

Inhibitors Comment Organism Structure
KF
-
Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane-bound Mesocricetus auratus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ Mesocricetus auratus mevalonate is required for cholesterol and isoprenoid synthesis (R)-mevalonate + NAD+ + CoA
-
?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
chinese hamster
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein near the C-terminus Mesocricetus auratus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.922
-
wild-type enzyme, [14C]-mevalonate acylation Mesocricetus auratus
1.203
-
S871A [14C]-mevalonate acylation Mesocricetus auratus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-mevalonate + CoA + 2 NAD+
-
Mesocricetus auratus (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
?
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ mevalonate is required for cholesterol and isoprenoid synthesis Mesocricetus auratus (R)-mevalonate + NAD+ + CoA
-
?