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Literature summary for 1.1.1.88 extracted from

  • Jordan-Starck, T.C.; Rodwell, V.W.
    Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Characterization and chemical modification (1989), J. Biol. Chem., 264, 17913-17918.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CoA mevaldehyde reduction Pseudomonas mevalonii
pantetheine mevaldehyde reduction Pseudomonas mevalonii

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Pseudomonas mevalonii

General Stability

General Stability Organism
20 mM N-ethylmaleimide, 50 min, 12% activity Pseudomonas mevalonii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
CoASH oxidative acylation of mevalonate Pseudomonas mevalonii
0.17
-
NADH reductive deacylation to mevalonate Pseudomonas mevalonii
0.17
-
NAD+ mevaldate oxidation Pseudomonas mevalonii
0.22
-
mevalonate oxidative acylation of mevalonate Pseudomonas mevalonii
0.3
-
DL-3-hydroxy-3-methylglutaryl-CoA reductive deacylation to mevalonate Pseudomonas mevalonii
0.37
-
NAD+ oxidative acylation of mevalonate Pseudomonas mevalonii
1.36
-
DL-mevaldate mevaldate oxidation Pseudomonas mevalonii
36
-
DL-mevaldate mevaldate reduction to mevalonate Pseudomonas mevalonii

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Pseudomonas mevalonii 5829
-

Organism

Organism UniProt Comment Textmining
Pseudomonas mevalonii
-
formerly Pseudomonas sp. M
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas mevalonii

Storage Stability

Storage Stability Organism
-180°C, 400 mM KCl, 12 months Pseudomonas mevalonii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-mevalonate + CoA + 2 NAD+
-
Pseudomonas mevalonii (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r
3-hydroxy-3-methylglutaryl-CoA + NADH + H+
-
Pseudomonas mevalonii mevalonate + CoA + NAD+
-
?
DL-mevaldate + CoA + NAD+
-
Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA NADH + H+
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pseudomonas mevalonii
NADH reverse reaction Pseudomonas mevalonii