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Literature summary for 1.1.1.86 extracted from

  • Wang, B.; Ma, Y.; Li, Y.; Wang, S.; Li, Z.
    The design, synthesis of amide KARI inhibitors and their biological activities (2009), Front. Chem. Chin., 4, 186-190.
No PubMed abstract available

Application

Application Comment Organism
drug development the enzyme is a promising target for the design of herbicides Spinacia oleracea

Inhibitors

Inhibitors Comment Organism Structure
11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one
-
Spinacia oleracea
2-(4-benzylpiperazin-1-yl)-N-arylacetamide
-
Spinacia oleracea
2-(4-methoxybenzamido)benzoic acid
-
Spinacia oleracea
2-[2-(4-morpholino)]acetamido-4-methylthiazole
-
Spinacia oleracea
additional information molecular design of KARI inhibitors, and synthesis, overview. Structure-function relationship, analysis by computational docking of inhibitor molecules to cyrstal structure. No inhibition by 5-[(4-morpholino/piperidin-1-yl)acetyl]-10 Spinacia oleracea
N-(2-(piperidin-1-yl)ethyl)phthalimide
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Spinacia oleracea

Organism

Organism UniProt Comment Textmining
Spinacia oleracea
-
-
-

Synonyms

Synonyms Comment Organism
acetohydroxy acid isomeroreductase
-
Spinacia oleracea
AHIR
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Spinacia oleracea
KARI
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Spinacia oleracea

General Information

General Information Comment Organism
metabolism one of the key enzymes for the synthesis of branched-chain amino acids isoleucine, leucine and valine Spinacia oleracea