BRENDA - Enzyme Database show
show all sequences of 1.1.1.66

Omega-hydroxy fatty acid dehydrogenase

Mitz, M.A.; Heinrikson, R.L.; Biochim. Biophys. Acta 46, 45-50 (1961)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.066
-
NAD+
-
Sus scrofa
0.08
-
11-Hydroxyundecanoate
-
Sus scrofa
0.125
-
10-Hydroxydecanoate
-
Sus scrofa
40
-
9-Hydroxynonanoate
-
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Equus caballus
5737
-
cytoplasm
-
Oryctolagus cuniculus
5737
-
cytoplasm
-
Ovis aries
5737
-
cytoplasm
-
Rattus norvegicus
5737
-
cytoplasm
-
Sus scrofa
5737
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Equus caballus
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
-
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Sus scrofa
-
kidney
-
Sus scrofa
-
liver
-
Equus caballus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Ovis aries
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
additional information
-
223, units defined as change in optical density at 340 nm of 0.001/min
Sus scrofa
Storage Stability
Storage Stability
Organism
4C, crude extract stable for a week
Sus scrofa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
10-hydroxydecanoate + NAD+
-
207967
Rattus norvegicus
10-oxodecanoate + NADH
-
207967
Rattus norvegicus
?
10-hydroxydecanoate + NAD+
-
207967
Oryctolagus cuniculus
10-oxodecanoate + NADH
-
207967
Oryctolagus cuniculus
?
10-hydroxydecanoate + NAD+
-
207967
Ovis aries
10-oxodecanoate + NADH
-
207967
Ovis aries
?
10-hydroxydecanoate + NAD+
-
207967
Equus caballus
10-oxodecanoate + NADH
-
207967
Equus caballus
?
10-hydroxydecanoate + NAD+
best substrate
207967
Sus scrofa
10-oxodecanoate + NADH
-
207967
Sus scrofa
r
11-hydroxyundecanoate + NAD+
-
207967
Rattus norvegicus
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
-
207967
Oryctolagus cuniculus
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
-
207967
Ovis aries
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
-
207967
Equus caballus
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
oxidation at 89% the rate of 10-hydroxydecanoic acid
207967
Sus scrofa
11-oxoundecanoate + NADH
-
207967
Sus scrofa
?
9-hydroxynonanoate + NAD+
-
207967
Rattus norvegicus
9-oxononanoate + NADH
-
207967
Rattus norvegicus
?
9-hydroxynonanoate + NAD+
-
207967
Oryctolagus cuniculus
9-oxononanoate + NADH
-
207967
Oryctolagus cuniculus
?
9-hydroxynonanoate + NAD+
-
207967
Ovis aries
9-oxononanoate + NADH
-
207967
Ovis aries
?
9-hydroxynonanoate + NAD+
-
207967
Equus caballus
9-oxononanoate + NADH
-
207967
Equus caballus
?
9-hydroxynonanoate + NAD+
oxidation at 51% the rate of 10-hydroxydecanoic acid
207967
Sus scrofa
9-oxononanoate + NADH
-
207967
Sus scrofa
?
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Rattus norvegicus
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Sus scrofa
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Oryctolagus cuniculus
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Ovis aries
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Equus caballus
?
-
-
-
-
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Equus caballus
37
-
assay at
Oryctolagus cuniculus
37
-
assay at
Ovis aries
37
-
assay at
Rattus norvegicus
37
-
assay at
Sus scrofa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
10
-
-
Sus scrofa
pH Range
pH Minimum
pH Maximum
Commentary
Organism
9
11
about half-maximal activity at pH 9.0 and 11.0
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
cannot be replaced by NADP+
Equus caballus
NAD+
cannot be replaced by NADP+
Oryctolagus cuniculus
NAD+
cannot be replaced by NADP+
Ovis aries
NAD+
cannot be replaced by NADP+
Rattus norvegicus
NAD+
cannot be replaced by NADP+
Sus scrofa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
cannot be replaced by NADP+
Equus caballus
NAD+
cannot be replaced by NADP+
Oryctolagus cuniculus
NAD+
cannot be replaced by NADP+
Ovis aries
NAD+
cannot be replaced by NADP+
Rattus norvegicus
NAD+
cannot be replaced by NADP+
Sus scrofa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.066
-
NAD+
-
Sus scrofa
0.08
-
11-Hydroxyundecanoate
-
Sus scrofa
0.125
-
10-Hydroxydecanoate
-
Sus scrofa
40
-
9-Hydroxynonanoate
-
Sus scrofa
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Equus caballus
5737
-
cytoplasm
-
Oryctolagus cuniculus
5737
-
cytoplasm
-
Ovis aries
5737
-
cytoplasm
-
Rattus norvegicus
5737
-
cytoplasm
-
Sus scrofa
5737
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Sus scrofa
-
kidney
-
Sus scrofa
-
liver
-
Equus caballus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Ovis aries
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
additional information
-
223, units defined as change in optical density at 340 nm of 0.001/min
Sus scrofa
Storage Stability (protein specific)
Storage Stability
Organism
4C, crude extract stable for a week
Sus scrofa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
10-hydroxydecanoate + NAD+
-
207967
Rattus norvegicus
10-oxodecanoate + NADH
-
207967
Rattus norvegicus
?
10-hydroxydecanoate + NAD+
-
207967
Oryctolagus cuniculus
10-oxodecanoate + NADH
-
207967
Oryctolagus cuniculus
?
10-hydroxydecanoate + NAD+
-
207967
Ovis aries
10-oxodecanoate + NADH
-
207967
Ovis aries
?
10-hydroxydecanoate + NAD+
-
207967
Equus caballus
10-oxodecanoate + NADH
-
207967
Equus caballus
?
10-hydroxydecanoate + NAD+
best substrate
207967
Sus scrofa
10-oxodecanoate + NADH
-
207967
Sus scrofa
r
11-hydroxyundecanoate + NAD+
-
207967
Rattus norvegicus
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
-
207967
Oryctolagus cuniculus
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
-
207967
Ovis aries
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
-
207967
Equus caballus
11-oxoundecanoate + NADH
-
-
-
?
11-hydroxyundecanoate + NAD+
oxidation at 89% the rate of 10-hydroxydecanoic acid
207967
Sus scrofa
11-oxoundecanoate + NADH
-
207967
Sus scrofa
?
9-hydroxynonanoate + NAD+
-
207967
Rattus norvegicus
9-oxononanoate + NADH
-
207967
Rattus norvegicus
?
9-hydroxynonanoate + NAD+
-
207967
Oryctolagus cuniculus
9-oxononanoate + NADH
-
207967
Oryctolagus cuniculus
?
9-hydroxynonanoate + NAD+
-
207967
Ovis aries
9-oxononanoate + NADH
-
207967
Ovis aries
?
9-hydroxynonanoate + NAD+
-
207967
Equus caballus
9-oxononanoate + NADH
-
207967
Equus caballus
?
9-hydroxynonanoate + NAD+
oxidation at 51% the rate of 10-hydroxydecanoic acid
207967
Sus scrofa
9-oxononanoate + NADH
-
207967
Sus scrofa
?
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Rattus norvegicus
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Sus scrofa
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Oryctolagus cuniculus
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Ovis aries
?
-
-
-
-
additional information
C1- to C4- or C18-omega-hydroxy acids, primary alcohols with or without functional groups, i.e. amino, carboxy or a second hydroxyl, or secondary fatty acid alcohols are not oxidized
207967
Equus caballus
?
-
-
-
-
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
37
-
assay at
Equus caballus
37
-
assay at
Oryctolagus cuniculus
37
-
assay at
Ovis aries
37
-
assay at
Rattus norvegicus
37
-
assay at
Sus scrofa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
10
-
-
Sus scrofa
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
9
11
about half-maximal activity at pH 9.0 and 11.0
Sus scrofa
Other publictions for EC 1.1.1.66
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
207967
Mitz
Omega-hydroxy fatty acid dehyd ...
Equus caballus, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
46
45-50
1961
-
-
-
-
-
-
-
4
5
-
-
-
-
5
-
-
1
-
-
7
1
1
20
-
5
-
-
-
1
1
-
5
-
-
-
-
-
-
5
-
-
-
-
-
-
4
5
-
-
-
-
-
-
1
-
7
1
1
20
-
5
-
-
-
1
1
-
-
-
-
-
-
-
-