BRENDA - Enzyme Database show
show all sequences of 1.1.1.64

Androgen metabolism via 17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme

Mindnich, R.; Haller, F.; Halbach, F.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.; J. Mol. Endocrinol. 35, 305-316 (2005)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Danio rerio
5783
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Danio rerio
-
-
-
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
low activity in both sexes
Danio rerio
-
embryo
during embryogenesis the enzyme is present from the sphere stage until hatching
Danio rerio
-
eye
-
Danio rerio
-
heart
expression in male, hardly detectable in female
Danio rerio
-
intestine
expression in male, hardly detectable in female
Danio rerio
-
kidney
expression in male, hardly detectable in female
Danio rerio
-
liver
-
Danio rerio
-
muscle
-
Danio rerio
-
skin
expression in male, hardly detectable in female
Danio rerio
-
spleen
expression in male, hardly detectable in female
Danio rerio
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-hydroxy-androstenedione + NADPH
-
669905
Homo sapiens
11beta-hydroxy-testosterone
-
-
-
?
11-hydroxy-androstenedione + NADPH
-
669905
Danio rerio
11beta-hydroxy-testosterone
-
-
-
?
11-ketoandrostenedione + NADPH
-
669905
Homo sapiens
11-ketotestosterone + NADP+
-
-
-
?
11-ketoandrostenedione + NADPH
-
669905
Danio rerio
11-ketotestosterone + NADP+
-
-
-
?
androstanedione + NADPH
-
669905
Homo sapiens
dihydrotestosterone + NADP+
-
-
-
?
androstenedione + NADPH + H+
-
669905
Homo sapiens
testosterone + NADP+
-
-
-
r
androstenedione + NADPH + H+
-
669905
Danio rerio
testosterone + NADP+
-
-
-
r
androsterone + NADPH
-
669905
Homo sapiens
androstane-3beta,17beta-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NADPH
-
669905
Homo sapiens
androst-5-en-3beta,17beta-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NADPH
-
669905
Danio rerio
androst-5-en-3beta,17beta-diol + NADP+
-
-
-
?
epiandrosterone + NADPH
-
669905
Homo sapiens
androstane-3beta,17beta-diol + NADP+
-
-
-
?
epiandrosterone + NADPH
-
669905
Danio rerio
androstane-3beta,17beta-diol + NADP+
-
-
-
?
testosterone + NAD+
NAD+ shows 20% of the activity with NADP+
669905
Homo sapiens
androstenedione + NADH
-
-
-
ir
testosterone + NAD+
NAD+ shows ess than 10% of the activity with NADP+
669905
Danio rerio
androstenedione + NADH
-
-
-
ir
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
less than 10% of the activity with NADP+, cosubstrate: testosterone
Danio rerio
NAD+
20% of the activity with NADP+, cosubstrate: testosterone
Homo sapiens
NADP+
-
Danio rerio
NADP+
-
Homo sapiens
NADPH
no activity with NADH
Danio rerio
NADPH
no activity with NADH
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
less than 10% of the activity with NADP+, cosubstrate: testosterone
Danio rerio
NAD+
20% of the activity with NADP+, cosubstrate: testosterone
Homo sapiens
NADP+
-
Danio rerio
NADP+
-
Homo sapiens
NADPH
no activity with NADH
Danio rerio
NADPH
no activity with NADH
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Danio rerio
5783
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
low activity in both sexes
Danio rerio
-
embryo
during embryogenesis the enzyme is present from the sphere stage until hatching
Danio rerio
-
eye
-
Danio rerio
-
heart
expression in male, hardly detectable in female
Danio rerio
-
intestine
expression in male, hardly detectable in female
Danio rerio
-
kidney
expression in male, hardly detectable in female
Danio rerio
-
liver
-
Danio rerio
-
muscle
-
Danio rerio
-
skin
expression in male, hardly detectable in female
Danio rerio
-
spleen
expression in male, hardly detectable in female
Danio rerio
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
11-hydroxy-androstenedione + NADPH
-
669905
Homo sapiens
11beta-hydroxy-testosterone
-
-
-
?
11-hydroxy-androstenedione + NADPH
-
669905
Danio rerio
11beta-hydroxy-testosterone
-
-
-
?
11-ketoandrostenedione + NADPH
-
669905
Homo sapiens
11-ketotestosterone + NADP+
-
-
-
?
11-ketoandrostenedione + NADPH
-
669905
Danio rerio
11-ketotestosterone + NADP+
-
-
-
?
androstanedione + NADPH
-
669905
Homo sapiens
dihydrotestosterone + NADP+
-
-
-
?
androstenedione + NADPH + H+
-
669905
Homo sapiens
testosterone + NADP+
-
-
-
r
androstenedione + NADPH + H+
-
669905
Danio rerio
testosterone + NADP+
-
-
-
r
androsterone + NADPH
-
669905
Homo sapiens
androstane-3beta,17beta-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NADPH
-
669905
Homo sapiens
androst-5-en-3beta,17beta-diol + NADP+
-
-
-
?
dehydroepiandrosterone + NADPH
-
669905
Danio rerio
androst-5-en-3beta,17beta-diol + NADP+
-
-
-
?
epiandrosterone + NADPH
-
669905
Homo sapiens
androstane-3beta,17beta-diol + NADP+
-
-
-
?
epiandrosterone + NADPH
-
669905
Danio rerio
androstane-3beta,17beta-diol + NADP+
-
-
-
?
testosterone + NAD+
NAD+ shows 20% of the activity with NADP+
669905
Homo sapiens
androstenedione + NADH
-
-
-
ir
testosterone + NAD+
NAD+ shows ess than 10% of the activity with NADP+
669905
Danio rerio
androstenedione + NADH
-
-
-
ir
Other publictions for EC 1.1.1.64
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724719
Matsunaga
Pathophysiological roles of al ...
Homo sapiens
Chem. Biol. Interact.
202
234-242
2013
-
1
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-
1
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1
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2
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1
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1
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2
-
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1
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-
1
-
-
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-
1
1
1
1
1
1
724850
Legeza
The microsomal enzyme 17beta-h ...
Homo sapiens
Endocrinology
154
205-213
2013
-
-
1
-
-
-
-
-
1
-
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1
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1
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1
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-
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-
1
1
-
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-
724915
Heinrich
Synthesis and structure-activi ...
Homo sapiens
Eur. J. Med. Chem.
62
738-744
2013
-
-
-
1
-
-
3
-
-
-
-
-
-
1
-
-
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3
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1
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3
3
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724916
Gazvoda
2,3-diarylpropenoic acids as s ...
Homo sapiens
Eur. J. Med. Chem.
62
89-97
2013
-
-
-
1
-
-
4
-
-
-
-
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1
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4
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1
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4
4
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723866
Jackson
Structure of AKR1C3 with 3-phe ...
Homo sapiens
Acta Crystallogr. Sect. F
68
409-413
2012
-
-
1
1
-
-
1
-
-
-
-
-
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1
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724533
Chen
Crystal structures of AKR1C3 c ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
3492-3497
2012
-
-
-
1
-
-
2
-
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1
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1
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1
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1
2
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724536
Harada
Identification of oxazolidined ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
504-507
2012
-
-
-
-
-
-
2
-
-
-
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1
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-
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724538
Sinreih
N-Benzoyl anthranilic acid der ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
5948-5951
2012
-
-
-
-
-
-
4
-
-
-
-
-
-
1
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4
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4
4
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-
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724555
Harada
Discovery of potent and orally ...
Homo sapiens, Rattus norvegicus
Bioorg. Med. Chem.
20
3242-3254
2012
-
-
1
-
-
-
6
-
-
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2
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1
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5
6
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724715
Yuan
Effects of phthalates on 3beta ...
Homo sapiens, Rattus norvegicus
Chem. Biol. Interact.
195
180-188
2012
-
-
-
-
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4
-
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2
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2
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8
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8
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8
4
8
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2
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725153
Miller
Aldo-keto reductase family 1 m ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
5
278-289
2012
-
1
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-
-
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-
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1
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8
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1
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8
-
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725671
Brozic
Selective inhibitors of aldo-k ...
Homo sapiens
J. Med. Chem.
55
7417-7424
2012
-
-
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1
-
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2
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1
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1
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2
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1
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2
2
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1
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725825
Byrns
Overexpression of aldo-keto re ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
130
7-15
2012
-
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1
1
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724517
Adeniji
Discovery of substituted 3-(ph ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
1464-1468
2011
-
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-
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3
-
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1
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3
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1
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724550
Maltais
Development of 3-substituted-a ...
Homo sapiens
Bioorg. Med. Chem.
19
4652-4668
2011
-
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1
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2
-
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1
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726493
Latif
Role of 11beta-OH-C(19) and C( ...
Rattus norvegicus
Steroids
76
682-689
2011
-
-
-
-
-
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1
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1
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1
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1
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1
1
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-
725152
Zakharov
Suppressed expression of type ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
3
608-617
2010
-
1
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1
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1
-
-
699845
Hu
The (+)- and (-)-gossypols pot ...
Homo sapiens, Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
115
14-19
2009
-
-
-
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4
-
2
-
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4
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4
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2
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2
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4
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2
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4
4
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2
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4
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2
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11
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Multifunctionality of human 17 ...
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Androsterone 3alpha-ether-3bet ...
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Androgen metabolism via 17beta ...
Danio rerio, Homo sapiens
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6
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6
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657673
Khan
Human 17beta-hydroxysteroid de ...
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2004
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2
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Inhibitors of 17beta-hydroxyst ...
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
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21
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658172
McKeever
Amino acid substitution of arg ...
Homo sapiens
Biochim. Biophys. Acta
1601
29-37
2002
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6
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6
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1
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1
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2
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le Lain
Some coumarins and triphenylet ...
Homo sapiens
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2002
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6
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6
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287221
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Molecular genetics and pathoph ...
Homo sapiens
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1996
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287222
Baker
Unusual evolution of 11beta- a ...
Homo sapiens
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1995
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287223
Geissler
Male pseudohermaphroditism cau ...
Homo sapiens
Nature Genet.
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1994
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Hara
Kinetic and stereochemical stu ...
Mus musculus
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287225
Inano
Testicular 17beta-hydroxystero ...
Oryctolagus cuniculus, Ovis aries, Rattus norvegicus, Sus scrofa
Steroids
48
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1986
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287226
Hara
Guinea-pig liver testosterone ...
Cavia porcellus
Biochem. J.
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1985
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287227
Inano
Amino acid composition and imm ...
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287228
Kageura
Purification and properties of ...
Cavia porcellus
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287229
Inano
Relationship between steroids ...
Sus scrofa
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Testicular 17beta-hydroxystero ...
Rattus norvegicus, Sus scrofa
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6
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1975
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287231
Inano
Purificatition and properties ...
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287232
Oshima
On testicular 17beta-hydroxyst ...
Homo sapiens, Oryctolagus cuniculus
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306
227-236
1973
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Villee
Some properties of the pyridin ...
Cavia porcellus
J. Biol. Chem.
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Endahl
Separation of a triphosphopyri ...
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