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Literature summary for 1.1.1.6 extracted from

  • Lin, E.C.C.; Magasanik, B.
    The activation of glycerol dehydrogenase from Aerobacter aerogenes by monovalent cations (1960), J. Biol. Chem., 235, 1820-1823.
    View publication on PubMed
Search for more literature for 1.1.1.6

Activating Compound

Activating Compound Comment Organism Structure
NH4+
-
 Klebsiella aerogenes

Inhibitors

Inhibitors Comment Organism Structure
2,2'-bipyridyl powerful inhibition Klebsiella aerogenes
8-Quinolinol
-
 Klebsiella aerogenes
diethyldithiocarbamate slight inhibition, 2 mM, 10 mM Klebsiella aerogenes
EDTA slight inhibition, 10 mM Klebsiella aerogenes
Zn2+ 50% inhibition at 0.021 mM Klebsiella aerogenes

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm soluble, isolation from crude cell extract Klebsiella aerogenes 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycerol + NAD+ Klebsiella aerogenes
-
 dihydroxyacetone + NADH + H+
-
 ?
glycerol + NAD+ Klebsiella aerogenes P14
-
 dihydroxyacetone + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
-
-
Klebsiella aerogenes P14
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Klebsiella aerogenes

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
16
-
-
 Klebsiella aerogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-propanediol + NAD+
-
 Klebsiella aerogenes hydroxyacetone + NADH
-
 ?
1,2-propanediol + NAD+
-
 Klebsiella aerogenes P14 hydroxyacetone + NADH
-
 ?
1,3-dichloro-2-propanol + NAD+
-
 Klebsiella aerogenes 1,3-dichloro-2-propanone + NADH
-
 ?
1,3-dichloro-2-propanol + NAD+
-
 Klebsiella aerogenes P14 1,3-dichloro-2-propanone + NADH
-
 ?
1-chloro-2,3-propanediol + NAD+
-
 Klebsiella aerogenes ?
-
 ?
1-chloro-2,3-propanediol + NAD+
-
 Klebsiella aerogenes P14 ?
-
 ?
glycerol + NAD+
-
 Klebsiella aerogenes dihydroxyacetone + NADH + H+
-
 ?
glycerol + NAD+
-
 Klebsiella aerogenes P14 dihydroxyacetone + NADH + H+
-
 ?
glycerol-alpha-monomethyl ether + NAD+
-
 Klebsiella aerogenes ?
-
 ?
glycerol-alpha-monomethyl ether + NAD+
-
 Klebsiella aerogenes P14 ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
 oxidation of glycerol Klebsiella aerogenes

pH Range

pH Minimum pH Maximum Comment Organism
9 11 pH 9.0: maximal activity, pH 11.0.: nearly inactive, oxidation of glycerol Klebsiella aerogenes

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Klebsiella aerogenes
NADH
-
 Klebsiella aerogenes