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Literature summary for 1.1.1.59 extracted from

  • Otzen, C.; Bardl, B.; Jacobsen, I.D.; Nett, M.; Brock, M.
    Candida albicans utilizes a modified beta-oxidation pathway for the degradation of toxic propionyl-CoA (2014), J. Biol. Chem., 289, 8151-8169.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
(S)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
0.58
-
(R)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
5.37
-
3-hydroxypropanoate at pH 9.5 and 22°C Candida albicans
46.7
-
L-serine at pH 9.5 and 22°C Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Candida albicans 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39200
-
x * 39200, calculated from amino acid sequence Candida albicans
40000
-
x * 40000, SDS-PAGE Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxypropanoate + NAD+ Candida albicans preferred substrate 3-oxopropanoate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans A0A1D8PQ07
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxyisobutyrate + NAD+
-
Candida albicans 3-oxoisobutyrate + NADH + H+
-
?
(S)-3-hydroxyisobutyrate + NAD+
-
Candida albicans 3-oxoisobutyrate + NADH + H+
-
?
3-hydroxypropanoate + NAD+ preferred substrate Candida albicans 3-oxopropanoate + NADH + H+
-
?
L-serine + NAD+
-
Candida albicans 3-oxo-L-alanine + NADH + H+
-
?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Candida albicans
? x * 39200, calculated from amino acid sequence Candida albicans

Synonyms

Synonyms Comment Organism
Hpd1p
-
Candida albicans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.31
-
(R)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
2.48
-
(S)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
9.41
-
L-serine at pH 9.5 and 22°C Candida albicans
30.97
-
3-hydroxypropanoate at pH 9.5 and 22°C Candida albicans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
-
Candida albicans

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Candida albicans

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.202
-
L-serine at pH 9.5 and 22°C Candida albicans
2.26
-
(R)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans
5.77
-
3-hydroxypropanoate at pH 9.5 and 22°C Candida albicans
19.1
-
(S)-3-hydroxyisobutyrate at pH 9.5 and 22°C Candida albicans