BRENDA - Enzyme Database show
show all sequences of 1.1.1.59

Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde

Den, H.; Robinson, W.G.; Coon, M.J.; J. Biol. Chem. 234, 1666-1671 (1959)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.34
-
NAD+
-
Sus scrofa
20
-
3-hydroxypropanoate
-
Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-hydroxypropanoate + NAD+
Gallus gallus
-
3-oxopropanoate + NADH + H+
-
Gallus gallus
r
3-hydroxypropanoate + NAD+
Escherichia coli
-
3-oxopropanoate + NADH + H+
-
Escherichia coli
r
3-hydroxypropanoate + NAD+
Sus scrofa
-
3-oxopropanoate + NADH + H+
-
Sus scrofa
r
3-hydroxypropanoate + NAD+
Tetrahymena pyriformis
-
3-oxopropanoate + NADH + H+
-
Tetrahymena pyriformis
r
3-hydroxypropanoate + NAD+
Propionibacterium freudenreichii subsp. shermanii
-
3-oxopropanoate + NADH + H+
-
Propionibacterium freudenreichii subsp. shermanii
r
3-hydroxypropanoate + NAD+
Eremothecium ashbyi
-
3-oxopropanoate + NADH + H+
-
Eremothecium ashbyi
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Eremothecium ashbyi
-
-
-
Escherichia coli
-
-
-
Gallus gallus
-
-
-
Propionibacterium freudenreichii subsp. shermanii
-
-
-
Sus scrofa
-
-
-
Tetrahymena pyriformis
-
-
-
Purification (Commentary)
Commentary
Organism
partially
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Sus scrofa
-
kidney
-
Sus scrofa
-
liver
-
Sus scrofa
-
pectoral muscle
-
Gallus gallus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Eremothecium ashbyi
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Escherichia coli
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Gallus gallus
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Propionibacterium freudenreichii subsp. shermanii
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Sus scrofa
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Tetrahymena pyriformis
Storage Stability
Storage Stability
Organism
several weeks, frozen
Sus scrofa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxypropanoate + NAD+
-
287142
Gallus gallus
3-oxopropanoate + NADH + H+
-
287142
Gallus gallus
r
3-hydroxypropanoate + NAD+
-
287142
Escherichia coli
3-oxopropanoate + NADH + H+
-
287142
Escherichia coli
r
3-hydroxypropanoate + NAD+
-
287142
Sus scrofa
3-oxopropanoate + NADH + H+
-
287142
Sus scrofa
r
3-hydroxypropanoate + NAD+
-
287142
Tetrahymena pyriformis
3-oxopropanoate + NADH + H+
-
287142
Tetrahymena pyriformis
r
3-hydroxypropanoate + NAD+
-
287142
Propionibacterium freudenreichii subsp. shermanii
3-oxopropanoate + NADH + H+
-
287142
Propionibacterium freudenreichii subsp. shermanii
r
3-hydroxypropanoate + NAD+
-
287142
Eremothecium ashbyi
3-oxopropanoate + NADH + H+
-
287142
Eremothecium ashbyi
r
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
10
-
-
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Eremothecium ashbyi
NAD+
-
Escherichia coli
NAD+
-
Gallus gallus
NAD+
-
Propionibacterium freudenreichii subsp. shermanii
NAD+
-
Sus scrofa
NAD+
-
Tetrahymena pyriformis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Eremothecium ashbyi
NAD+
-
Escherichia coli
NAD+
-
Gallus gallus
NAD+
-
Propionibacterium freudenreichii subsp. shermanii
NAD+
-
Sus scrofa
NAD+
-
Tetrahymena pyriformis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.34
-
NAD+
-
Sus scrofa
20
-
3-hydroxypropanoate
-
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-hydroxypropanoate + NAD+
Gallus gallus
-
3-oxopropanoate + NADH + H+
-
Gallus gallus
r
3-hydroxypropanoate + NAD+
Escherichia coli
-
3-oxopropanoate + NADH + H+
-
Escherichia coli
r
3-hydroxypropanoate + NAD+
Sus scrofa
-
3-oxopropanoate + NADH + H+
-
Sus scrofa
r
3-hydroxypropanoate + NAD+
Tetrahymena pyriformis
-
3-oxopropanoate + NADH + H+
-
Tetrahymena pyriformis
r
3-hydroxypropanoate + NAD+
Propionibacterium freudenreichii subsp. shermanii
-
3-oxopropanoate + NADH + H+
-
Propionibacterium freudenreichii subsp. shermanii
r
3-hydroxypropanoate + NAD+
Eremothecium ashbyi
-
3-oxopropanoate + NADH + H+
-
Eremothecium ashbyi
r
Purification (Commentary) (protein specific)
Commentary
Organism
partially
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Sus scrofa
-
kidney
-
Sus scrofa
-
liver
-
Sus scrofa
-
pectoral muscle
-
Gallus gallus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Eremothecium ashbyi
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Escherichia coli
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Gallus gallus
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Propionibacterium freudenreichii subsp. shermanii
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Sus scrofa
additional information
-
1.000, 1 unit defined as 0.001 increase in optical density
Tetrahymena pyriformis
Storage Stability (protein specific)
Storage Stability
Organism
several weeks, frozen
Sus scrofa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxypropanoate + NAD+
-
287142
Gallus gallus
3-oxopropanoate + NADH + H+
-
287142
Gallus gallus
r
3-hydroxypropanoate + NAD+
-
287142
Escherichia coli
3-oxopropanoate + NADH + H+
-
287142
Escherichia coli
r
3-hydroxypropanoate + NAD+
-
287142
Sus scrofa
3-oxopropanoate + NADH + H+
-
287142
Sus scrofa
r
3-hydroxypropanoate + NAD+
-
287142
Tetrahymena pyriformis
3-oxopropanoate + NADH + H+
-
287142
Tetrahymena pyriformis
r
3-hydroxypropanoate + NAD+
-
287142
Propionibacterium freudenreichii subsp. shermanii
3-oxopropanoate + NADH + H+
-
287142
Propionibacterium freudenreichii subsp. shermanii
r
3-hydroxypropanoate + NAD+
-
287142
Eremothecium ashbyi
3-oxopropanoate + NADH + H+
-
287142
Eremothecium ashbyi
r
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
10
-
-
Sus scrofa
Other publictions for EC 1.1.1.59
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738640
Otzen
Candida albicans utilizes a mo ...
Candida albicans
J. Biol. Chem.
289
8151-8169
2014
-
-
-
-
-
-
-
4
1
-
-
1
-
4
-
-
-
-
-
-
-
-
4
1
-
-
-
4
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
4
1
-
-
1
-
-
-
-
-
-
-
-
4
1
-
-
-
4
1
-
-
-
-
-
-
-
4
4
695710
Yao
The catalytic property of 3-hy ...
Bacillus cereus, Bacillus cereus ATCC 14579, Bacillus cereus ATCC14579
Appl. Biochem. Biotechnol.
160
694-703
2009
-
-
1
-
-
-
1
5
-
1
1
2
-
10
-
-
1
-
-
-
1
-
5
1
1
1
2
2
1
1
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
5
-
1
1
2
-
-
-
1
-
-
1
-
5
1
1
1
2
2
1
1
-
-
-
-
-
-
2
2
655504
Qatibi
-
Anaerobic 1,3-propanediol diss ...
Desulfovibrio alcoholivorans, no activity in Desulfovibrio carbinolicus, no activity in Desulfovibrio fructosovorans
Eur. Symp. Environ. Biotechnol. , ESEB 2004, Proceedings, Oostende, Belgium, Apr. 25-28
2004
693-696
2004
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5348
Miyakoshi
-
Distribution of the methylcitr ...
Candida catenulata, Candida gropengiesseri, Candida rugosa, Priceomyces haplophilus, Schwanniomyces polymorphus
Agric. Biol. Chem.
51
2381-2387
1987
-
-
-
-
-
-
-
-
-
-
-
6
-
5
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287142
Den
Enzymatic conversion of beta-h ...
Eremothecium ashbyi, Escherichia coli, Gallus gallus, Propionibacterium freudenreichii subsp. shermanii, Sus scrofa, Tetrahymena pyriformis
J. Biol. Chem.
234
1666-1671
1959
-
-
-
-
-
-
-
2
-
-
-
6
-
6
-
-
1
-
-
4
6
1
6
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
6
-
-
-
-
-
-
2
-
-
-
6
-
-
-
1
-
4
6
1
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-