Data extracted from this reference:
Inhibitors
ATP
non-competitive
Escherichia coli
D-altronate
competitive at low concentrations; non-competitive
Escherichia coli
additional information
product inhibition with all products in forward and reverse reaction
Escherichia coli
p-chloromercuribenzoate
complete inhibition at 0.005 mM, non-competive, Ki: 0.0001 mM
Escherichia coli
tagaturonate
competitive, inhibitory on forward reaction
Escherichia coli
KM Value [mM]
0.5
D-fructuronate
Escherichia coli
0.9
D-tagaturonate
Escherichia coli
1.8
D-mannonate
Escherichia coli
Natural Substrates/ Products (Substrates)
D-mannonate + NAD+
Escherichia coli
D-fructuronate + NADH
Escherichia coli
r
Organism
Purification (Commentary)
Specific Activity [micromol/min/mg]
6
crude extract
Escherichia coli
320
purified enzyme
Escherichia coli
Substrates and Products (Substrate)
D-altronate + NAD+
287133
Escherichia coli
D-tagaturonate + NADH
287133
Escherichia coli
D-mannonate + NAD+
287133
Escherichia coli
D-fructuronate + NADH
287133
Escherichia coli
r
Temperature Stability [°C]
53
loss of activity, NADH, NADPH, fructuronate, tagaturonate, NAD+, mannonate and altronate protect against inactivation
Escherichia coli
pH Optimum
6.3
for NADH oxidation
Escherichia coli
8.4
for NAD reduction
Escherichia coli
Inhibitors (protein specific)
ATP
non-competitive
Escherichia coli
D-altronate
competitive at low concentrations; non-competitive
Escherichia coli
additional information
product inhibition with all products in forward and reverse reaction
Escherichia coli
p-chloromercuribenzoate
complete inhibition at 0.005 mM, non-competive, Ki: 0.0001 mM
Escherichia coli
tagaturonate
competitive, inhibitory on forward reaction
Escherichia coli
KM Value [mM] (protein specific)
0.5
D-fructuronate
Escherichia coli
0.9
D-tagaturonate
Escherichia coli
1.8
D-mannonate
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
D-mannonate + NAD+
Escherichia coli
D-fructuronate + NADH
Escherichia coli
r
Purification (Commentary) (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
6
crude extract
Escherichia coli
320
purified enzyme
Escherichia coli
Substrates and Products (Substrate) (protein specific)
D-altronate + NAD+
287133
Escherichia coli
D-tagaturonate + NADH
287133
Escherichia coli
D-mannonate + NAD+
287133
Escherichia coli
D-fructuronate + NADH
287133
Escherichia coli
r
Temperature Stability [°C] (protein specific)
53
loss of activity, NADH, NADPH, fructuronate, tagaturonate, NAD+, mannonate and altronate protect against inactivation
Escherichia coli
pH Optimum (protein specific)
6.3
for NADH oxidation
Escherichia coli
8.4
for NAD reduction
Escherichia coli
Other publictions for EC 1.1.1.57
287129
Portalier
D-Mannonate and D-altronate-NA ...
Escherichia coli
Methods Enzymol.
89
210-218
1982
-
-
-
-
-
-
1
2
-
-
-
1
-
1
-
-
1
-
-
-
2
1
3
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
1
-
-
-
1
-
-
2
1
3
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
287131
Mandrand-Berthelot
Hit-and-run mechanism for D-gl ...
Escherichia coli
Biochim. Biophys. Acta
483
6-23
1977
-
-
-
-
-
-
5
-
-
-
-
1
-
1
-
-
1
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287130
Portalier
Colorimetric determinations of ...
Escherichia coli
Biochim. Biophys. Acta
289
19-27
1972
-
-
-
-
-
-
-
1
-
-
-
2
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
287132
Portalier
D-Mannonate: NAD-oxidoreductas ...
Escherichia coli
Eur. J. Biochem.
30
220-233
1972
-
-
-
-
-
-
3
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
287133
Portalier
D-Mannonate: NAD oxidoreductas ...
Escherichia coli
Eur. J. Biochem.
26
290-300
1972
-
-
-
-
-
-
5
3
-
-
-
1
-
1
-
-
1
-
-
-
2
-
2
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
3
-
-
-
1
-
-
-
1
-
-
2
-
2
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
287128
Hickman
Uronic acid metabolism in bact ...
Escherichia coli
J. Biol. Chem.
235
1566-1570
1960
2
-
-
-
-
3
1
1
-
-
-
1
-
1
-
-
1
-
-
-
2
1
2
-
-
-
-
-
1
-
1
2
-
-
-
2
-
-
2
-
-
3
-
1
-
1
-
-
-
1
-
-
-
1
-
-
2
1
2
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-