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Literature summary for 1.1.1.51 extracted from

  • Mansour, M.F.; Pelletier, M.; Boulet, M.-M.; Mayrand, D.; Brochu, G.; Lebel, S.; Poirier, D.; Fradette, J.; Cianflone, K.; Luu-The, V.; Tchernof, A.
    Oxidative activity of 17beta-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17beta-HSD type 2 (2015), Mol. Cell. Endocrinol., 414, 168-176.
    View publication on PubMed
Search for more literature for 1.1.1.51

Cloned(Commentary)

Cloned (Comment) Organism
gene HSD17B2, quantitative real-time RT-PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EM-919 a 17beta-HSD type 2 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
testosterone + NAD(P)+ Homo sapiens
-
 androstenedione + NAD(P)H + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte real-time RT-PCR expression 17beta-HSD type 2 analysis Homo sapiens
-
adipose tissue male abdominal, 17beta-HSD type 2 is localized in the vasculature of the adipose compartment, real-time RT-PCR expression analysis Homo sapiens
-
preadipocyte real-time RT-PCR expression 17beta-HSD type 2 analysis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
testosterone + NAD(P)+
-
 Homo sapiens androstenedione + NAD(P)H + H+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-HSD type 2
-
 Homo sapiens
17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function conversion of testosterone to 4-dione detected in abdominal adipose tissue is caused by 17beta-HSD type 2 which is localized in the vasculature of the adipose compartment Homo sapiens