BRENDA - Enzyme Database show
show all sequences of 1.1.1.51

Structure and function of human 17beta-hydroxysteroid dehydrogenases

Lukacik, P.; Kavanagh, K.L.; Oppermann, U.; Mol. Cell. Endocrinol. 248, 61-71 (2006)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
the hydrophobic 17beta-HSD3 is membrane-bound through an N-terminal transmembrane domain
Homo sapiens
5783
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4-androstene-3,17-dione + NADPH + H+
Homo sapiens
isozymes 17beta-HSD3 and 17beta-HSD5
testosterone + NADP+
-
-
r
5-androstenedione + NADPH
Homo sapiens
isozyme 17beta-HSD3
5alpha-dihydrotestosterone + NADP+
-
-
r
additional information
Homo sapiens
the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
isozymes 17beta-HSD3 and 17beta-HSD5
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
isozyme 17beta-HSD5
Homo sapiens
-
gonad
isozymes 17beta-HSD3 and 17beta-HSD5
Homo sapiens
-
liver
isozyme 17beta-HSD5
Homo sapiens
-
prostate gland
isozyme 17beta-HSD5
Homo sapiens
-
testis
high expression level of isozyme 17beta-HSD5
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-androstene-3,17-dione + NADPH + H+
isozymes 17beta-HSD3 and 17beta-HSD5
675983
Homo sapiens
testosterone + NADP+
-
-
-
r
5-androstenedione + NADPH
isozyme 17beta-HSD3
675983
Homo sapiens
5alpha-dihydrotestosterone + NADP+
-
-
-
r
additional information
the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis
675983
Homo sapiens
?
-
-
-
-
additional information
isozyme 17beta-HSD5 also shows 3alpha- and 20alpha-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase, and prostaglandin synthase activities
675983
Homo sapiens
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
dependent on
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
dependent on
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
the hydrophobic 17beta-HSD3 is membrane-bound through an N-terminal transmembrane domain
Homo sapiens
5783
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4-androstene-3,17-dione + NADPH + H+
Homo sapiens
isozymes 17beta-HSD3 and 17beta-HSD5
testosterone + NADP+
-
-
r
5-androstenedione + NADPH
Homo sapiens
isozyme 17beta-HSD3
5alpha-dihydrotestosterone + NADP+
-
-
r
additional information
Homo sapiens
the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
isozyme 17beta-HSD5
Homo sapiens
-
gonad
isozymes 17beta-HSD3 and 17beta-HSD5
Homo sapiens
-
liver
isozyme 17beta-HSD5
Homo sapiens
-
prostate gland
isozyme 17beta-HSD5
Homo sapiens
-
testis
high expression level of isozyme 17beta-HSD5
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-androstene-3,17-dione + NADPH + H+
isozymes 17beta-HSD3 and 17beta-HSD5
675983
Homo sapiens
testosterone + NADP+
-
-
-
r
5-androstenedione + NADPH
isozyme 17beta-HSD3
675983
Homo sapiens
5alpha-dihydrotestosterone + NADP+
-
-
-
r
additional information
the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis
675983
Homo sapiens
?
-
-
-
-
additional information
isozyme 17beta-HSD5 also shows 3alpha- and 20alpha-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase, and prostaglandin synthase activities
675983
Homo sapiens
?
-
-
-
-
Other publictions for EC 1.1.1.51
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
725824
Svegelj
The role of Ala231 and Trp227 ...
Curvularia lunata
J. Steroid Biochem. Mol. Biol.
129
92-98
2012
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699146
Bruzzone
Immunohistochemical localizati ...
Pelophylax esculentus
J. Chem. Neuroanat.
39
35-50
2010
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711161
Nashev
The UV-filter benzophenone-1 i ...
Homo sapiens, Mus musculus, Rattus norvegicus
Biochem. Pharmacol.
79
1189-1199
2010
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16
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16
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3
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712881
Zhao
Inhibition of 3beta- and 17bet ...
Rattus norvegicus
J. Steroid Biochem. Mol. Biol.
118
13-17
2010
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1
1
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4
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1
4
1
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2
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713329
Ernst
Expression of 3beta-HSD and P5 ...
Digitalis lanata
Planta Med.
76
923-927
2010
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1
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4
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5
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4
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4
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1
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1
1
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4
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4
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4
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1
1
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696052
Higo
Comparison of sex-steroid synt ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
385
62-66
2009
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1
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4
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1
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4
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700177
Senthilkumaran
Novel 3beta-hydroxysteroid deh ...
Oreochromis niloticus
Mol. Cell. Endocrinol.
299
146-152
2009
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1
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1
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4
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2
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2
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4
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700188
Chura
Steroid-converting enzymes in ...
Homo sapiens
Mol. Cell. Endocrinol.
301
51-58
2009
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1
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712925
De Catalfo
Influence of commercial dietar ...
Rattus norvegicus
Lipids
44
345-357
2009
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1
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1
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686428
Arukwe
Modulation of steroidogenesis ...
Danio rerio
Environ. Res.
107
362-370
2008
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686929
Prisco
Immunolocalization of 3beta-HS ...
Torpedo marmorata
Gen. Comp. Endocrinol.
155
157-163
2008
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3
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690081
Parthasarathy
Assessment of in vitro effects ...
Rattus norvegicus
Steroids
73
328-338
2008
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691108
Hunter
Transformation of 5-ene steroi ...
Aspergillus tamarii, Aspergillus tamarii KITA
Biochim. Biophys. Acta
1791
110-117
2008
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5
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6
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684324
Aizawa
Expression of steroidogenic en ...
Rattus norvegicus
Am. J. Physiol.
292
E577-E584
2007
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687324
Chen
Gene expression of 3beta-hydro ...
Sus scrofa
J. Anim. Sci.
85
2457-2463
2007
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688683
Luu-The
Steroid metabolism and profile ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
107
30-36
2007
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689697
Herl
Delta5-3beta-hydroxysteroid de ...
Digitalis lanata
Planta Med.
73
704-710
2007
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1
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8
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1
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3
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1
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1
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6
1
1
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1
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1
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8
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6
1
1
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1
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1
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670259
Ngatcha
3beta-Alkyl-androsterones as i ...
Homo sapiens
Mol. Cell. Endocrinol.
248
225-232
2006
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5
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1
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5
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1
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670273
Luu-The
Characterization of type 12 17 ...
Homo sapiens
Mol. Endocrinol.
20
437-443
2006
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1
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1
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1
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3
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672586
Fink
Identification of a novel seri ...
Homo sapiens
Bioorg. Med. Chem. Lett.
16
1532-1536
2006
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44
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1
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2
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46
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46
44
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673553
Ulrih
Conformational stability of 17 ...
Curvularia lunata
FEBS J.
273
3927-3937
2006
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2
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1
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1
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2
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1
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675983
Lukacik
Structure and function of huma ...
Homo sapiens
Mol. Cell. Endocrinol.
248
61-71
2006
-
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