Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, phylogenetic tree, transient expression in HEK-293 cells | Homo sapiens |
DNA and amino acid sequence determination and analysis, phylogenetic tree, transient expression in zf4 cells | Danio rerio |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Danio rerio | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
androstenedione + NADPH + H+ | Homo sapiens | - |
testosterone + NADP+ | - |
r | |
androstenedione + NADPH + H+ | Danio rerio | - |
testosterone + NADP+ | - |
r | |
additional information | Homo sapiens | evolutionary considerations | ? | - |
? | |
additional information | Danio rerio | evolutionary considerations | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | Q6QA32 | - |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | enzyme expression during embryogenesis from sphere to 84 h post-fertilization | Danio rerio | - |
HEK-293 cell | low expression level | Homo sapiens | - |
liver | highest enzyme expression in male liver | Danio rerio | - |
additional information | expression in female and male tissues, sexual dimorphism, no activity in zf4 cells | Danio rerio | - |
ovary | highest enzyme expression in female ovaries | Danio rerio | - |
testis | almost exclusively | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH | i.e. 11beta-hydroxy-androstenedione, reduction at C17 | Homo sapiens | 11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+ | i.e. 11beta-testosterone | ? | |
11beta-hydroxyandrost-5-ene-3,17-dione + NADPH | i.e. 11beta-hydroxy-androstenedione, reduction at C17 | Danio rerio | 11beta,17beta-dihydroxyandrost-5-ene-3-one + NADP+ | i.e. 11beta-testosterone | ? | |
androst-5-ene-3,11,17-trione + NADPH | i.e. 11-keto-androstenedione, reduction at C17 | Danio rerio | 17beta-hydroxyandrost-5-ene-3,11-dione + NADP+ | i.e. 11-keto-testosterone | ? | |
androst-5-ene-3,11,17-trione + NADPH | i.e. 11-ketoandrostenedione, reduction at C17 | Homo sapiens | 17beta-hydroxyandrost-5-ene-3,11-dione + NADP+ | i.e. 11-keto-testosterone | ? | |
androstanedione + NADPH | reduction at C17 | Homo sapiens | dihydrotestosterone + NADP+ | - |
? | |
androstenedione + NADPH + H+ | - |
Homo sapiens | testosterone + NADP+ | - |
r | |
androstenedione + NADPH + H+ | - |
Danio rerio | testosterone + NADP+ | - |
r | |
androstenedione + NADPH + H+ | the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview | Homo sapiens | testosterone + NADP+ | - |
r | |
androstenedione + NADPH + H+ | the forward reaction is preferred, no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview | Danio rerio | testosterone + NADP+ | - |
r | |
androsterone + NADPH + H+ | reduction at C17 | Homo sapiens | androstane-3beta,17beta-diol + NADP+ | - |
? | |
dehydroepiandrosterone + NADPH + H+ | reduction at C17 | Homo sapiens | 5-androstene-3beta,17beta-diol + NADP+ | - |
? | |
dehydroepiandrosterone + NADPH + H+ | reduction at C17 | Danio rerio | 5-androstene-3beta,17beta-diol + NADP+ | - |
? | |
epiandrosterone + NADPH | reduction at C17 | Danio rerio | androstane-3beta,17beta-diol + NADP+ | - |
? | |
epiandrosterone + NADPH | reduction at C17 | Homo sapiens | 5-androstane-3beta,17beta-diol + NADP+ | - |
? | |
additional information | evolutionary considerations | Homo sapiens | ? | - |
? | |
additional information | evolutionary considerations | Danio rerio | ? | - |
? | |
additional information | no activity with androstanedione and androsterone | Danio rerio | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD type 3 | - |
Homo sapiens |
17beta-HSD type 3 | - |
Danio rerio |
17beta-hydroxysteroid dehydrogenase type 3 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 3 | - |
Danio rerio |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview | Homo sapiens | |
additional information | no activity with NADH in the forward reaction, poor activity with NAD+ in the reverse raection, overview | Danio rerio | |
NADP+ | - |
Homo sapiens | |
NADP+ | - |
Danio rerio | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Danio rerio |