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Literature summary for 1.1.1.51 extracted from

  • Kwan, T.K.; Gower, D.B.
    Kinetic studies of 3alpha- and 3beta-hydroxysteroid dehydrogenase in neonatal porcine testis subcellular fractions (1984), Biochem. Soc. Trans., 12, 842-843.
No PubMed abstract available

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.068
-
5alpha-Androst-16-en-3-one microsomal enzyme Sus scrofa
0.107
-
5alpha-Androst-16-en-3-one mitochondrial enzyme Sus scrofa
0.176
-
5alpha-Androst-16-en-3-one cytosolic enzyme Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol 80% of activity Sus scrofa 5829
-
microsome
-
Sus scrofa
-
-
mitochondrion
-
Sus scrofa 5739
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
Landrace piglet
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-androst-16-en-3-one + NADH
-
Sus scrofa 3beta-hydroxy-5alpha-androst-16-ene + NAD+
-
?
testosterone + NAD(P)+
-
Sus scrofa androst-4-en-3,17-dione + NAD(P)H + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Sus scrofa
NADH
-
Sus scrofa