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Literature summary for 1.1.1.50 extracted from

  • Yunes, R.; Casas, S.; Gaglio, E.; Cabrera, R.
    Progesterone exerts a neuromodulatory effect on turning behavior of hemiparkinsonian male rats: expression of 3alpha-hydroxysteroid oxidoreductase and allopregnanolone as suggestive of GABA A receptors involvement (2015), Parkinsons Dis., 2015, 431690.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregn-4-en-3,20-dione + NADPH + H+ Rattus norvegicus progesterone 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r
pregn-4-en-3,20-dione + NADPH + H+ Rattus norvegicus Sprague-Dawley progesterone 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P23457
-
-
Rattus norvegicus Sprague-Dawley P23457
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain from male rats Rattus norvegicus
-
striatum
-
 Rattus norvegicus
-
substantia nigra
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregn-4-en-3,20-dione + NADPH + H+ progesterone Rattus norvegicus 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r
pregn-4-en-3,20-dione + NADPH + H+ progesterone Rattus norvegicus Sprague-Dawley 3alpha-hydroxypregn-4-en-20-one + NADP+ allopregnanolone r

Synonyms

Synonyms Comment Organism
3alpha-HSOR
-
 Rattus norvegicus
3alpha-hydroxysteroid oxidoreductase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Rattus norvegicus
NADPH
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the 3alpha-HSOR mRNA ipsilateral expression of progesterone-treated hemiparkinsonian animals is significantly augmented compared to sham and hemiparkinsonian rats. On the other hand, 3alpha-HSOR mRNA expression is no different among groups when substantia nigra samples contralateral to lesion are considered additional information

General Information

General Information Comment Organism
additional information effect of progesterone in lesions, caused by neurotoxic 6-hydroxydopamine hydrobromide, on the contralateral turning behavior, overview Rattus norvegicus