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Literature summary for 1.1.1.50 extracted from

  • Karavolas, H.J.; Hodges, D.R.
    Changes in pituitary, hypothalamic and brain progestin-metabolizing enzyme activities during lactation (1993), J. Steroid Biochem. Mol. Biol., 44, 299-303.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
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-
cytosol NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
r
5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus activity higher during lactation in female rats 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
r
5alpha-pregnan-3,20-dione + NADPH Rattus norvegicus
-
3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity
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Source Tissue

Source Tissue Comment Organism Textmining
brain distribution in brain regions of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
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brain NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity is decreased by 40-50% in lactating rats Rattus norvegicus
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hypophysis anterior Rattus norvegicus
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hypophysis cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, increase of both enzymes during lactation Rattus norvegicus
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hypothalamus cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-pregnan-3,20-dione + NAD(P)H
-
Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
?
5alpha-pregnan-3,20-dione + NAD(P)H + H+ 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
r
5alpha-pregnan-3,20-dione + NAD(P)H + H+ activity higher during lactation in female rats Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
r
5alpha-pregnan-3,20-dione + NADPH
-
Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
?
5alpha-pregnan-3,20-dione + NADPH
-
Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
r

Synonyms

Synonyms Comment Organism
5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase NADH- and NADPH-linked Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
NADPH cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus