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Literature summary for 1.1.1.50 extracted from

  • Krause, J.E.; Karavolas, H.J.
    Subcellular location of hypothalamic progesterone metabolizing enzymes and evidence for distinct NADH- and NADPH-linked 3alpha-hydroxysteroid oxidoreductase activities (1980), J. Steroid Biochem., 13, 271-280.
    View publication on PubMed
Search for more literature for 1.1.1.50

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
-
-
cytosol NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-pregnan-3,20-dione + NAD(P)H + H+ Rattus norvegicus 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
5alpha-pregnan-3,20-dione + NADPH Rattus norvegicus
-
 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 NADPH- and NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-pregnan-3,20-dione + NAD(P)H 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(P)+
-
 ?
5alpha-pregnan-3,20-dione + NAD(P)H + H+ 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity, utilizing NADH as cofactor when of particulate origin and NADPH when of cytosolic origin Rattus norvegicus 5alpha-pregnane-3alpha-ol-20-one + NAD(P)+
-
 r
5alpha-pregnan-3,20-dione + NADPH
-
 Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 ?
5alpha-pregnan-3,20-dione + NADPH
-
 Rattus norvegicus 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+
-
 r

Synonyms

Synonyms Comment Organism
3alpha-hydroxysteroid oxidoreductase NADH- and NADPH-linked Rattus norvegicus
5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH plasma membrane NADH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus
NADPH cytosolic NADPH-linked 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity Rattus norvegicus