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Literature summary for 1.1.1.50 extracted from

  • Nanjo, H.; Terada, T.; Umemura, T.; Nishinaka, T.; Mizoguchi, T.; Nishihara, T.
    Characterization of bovine liver cytosolic 3alpha-hydroxysteroid dehydrogenase and its aldo-keto reductase activity (1992), Int. J. Biochem., 24, 815-820.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
17alpha-methyltestosterone competitive inhibition Bos taurus
5,5'-dithiobis(2-nitrobenzoic acid)
-
Bos taurus
ethacrynate
-
Bos taurus
ethynylestradiol competitive inhibition Bos taurus
indomethacin
-
Bos taurus
megestrol competitive inhibition Bos taurus
sulfhydryl oxidizing reagents
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Bos taurus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus broad substrate range ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.15
-
purified enzyme Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha-hydroxy-5beta-androstan-17-one + NADP+
-
Bos taurus 5beta-androstan-3,17-dione + NADPH
-
r
5alpha-androstan-3,17-dione + NADPH + H+
-
Bos taurus 3alpha-hydroxy-5alpha-androstan-17-one + NADP+
-
r
5beta-androstan-3,17-dione + NADPH
-
Bos taurus 5beta-androstan-3alpha,17alpha-diol + NADP+
-
r
5beta-androstan-3alpha-ol-17-one + NADPH
-
Bos taurus 5beta-androstan-3alpha,17alpha-diol + NADP+
-
r
9,10-phenanthrenequinone + NADPH
-
Bos taurus ?
-
?
androsterone + NAD(P)+
-
Bos taurus 5alpha-androstan-3,17-dione + NAD(P)H
-
r
benzoylpyridine + NADPH
-
Bos taurus ?
-
?
camphorquinone + NADPH
-
Bos taurus ?
-
?
hydroxybutyrate + NADP+
-
Bos taurus oxobutanoate + NADPH
-
?
menadione + NADPH
-
Bos taurus ?
-
?
additional information reduction of carbonyl compounds e.g. quinones, aliphatic-chain diketones, ketones Bos taurus ?
-
?
additional information can not catalyze the dehydrogenation of 3beta-hydroxysteroids, epiandrosterone and 17beta-hydroxysteroids, i.e. testosterone and 17beta-estradiol Bos taurus ?
-
?
additional information broad substrate range Bos taurus ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 35000, SDS-PAGE Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Bos taurus
NADPH
-
Bos taurus