Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17alpha-methyltestosterone | competitive inhibition | Bos taurus | |
5,5'-dithiobis(2-nitrobenzoic acid) | - |
Bos taurus | |
ethacrynate | - |
Bos taurus | |
ethynylestradiol | competitive inhibition | Bos taurus | |
indomethacin | - |
Bos taurus | |
megestrol | competitive inhibition | Bos taurus | |
sulfhydryl oxidizing reagents | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Bos taurus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
gel filtration | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | broad substrate range | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.15 | - |
purified enzyme | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha-hydroxy-5beta-androstan-17-one + NADP+ | - |
Bos taurus | 5beta-androstan-3,17-dione + NADPH | - |
r | |
5alpha-androstan-3,17-dione + NADPH + H+ | - |
Bos taurus | 3alpha-hydroxy-5alpha-androstan-17-one + NADP+ | - |
r | |
5beta-androstan-3,17-dione + NADPH | - |
Bos taurus | 5beta-androstan-3alpha,17alpha-diol + NADP+ | - |
r | |
5beta-androstan-3alpha-ol-17-one + NADPH | - |
Bos taurus | 5beta-androstan-3alpha,17alpha-diol + NADP+ | - |
r | |
9,10-phenanthrenequinone + NADPH | - |
Bos taurus | ? | - |
? | |
androsterone + NAD(P)+ | - |
Bos taurus | 5alpha-androstan-3,17-dione + NAD(P)H | - |
r | |
benzoylpyridine + NADPH | - |
Bos taurus | ? | - |
? | |
camphorquinone + NADPH | - |
Bos taurus | ? | - |
? | |
hydroxybutyrate + NADP+ | - |
Bos taurus | oxobutanoate + NADPH | - |
? | |
menadione + NADPH | - |
Bos taurus | ? | - |
? | |
additional information | reduction of carbonyl compounds e.g. quinones, aliphatic-chain diketones, ketones | Bos taurus | ? | - |
? | |
additional information | can not catalyze the dehydrogenation of 3beta-hydroxysteroids, epiandrosterone and 17beta-hydroxysteroids, i.e. testosterone and 17beta-estradiol | Bos taurus | ? | - |
? | |
additional information | broad substrate range | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 35000, SDS-PAGE | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Bos taurus | |
NADPH | - |
Bos taurus |