Literature summary for 1.1.1.50 extracted from

Nimrod, A.; Lamprecht, S.A.; Lindner, H.R.
Separation and characterization of two 3-hydroxysteroid oxidoreductases from the soluble fraction of rat ovarian cells (1975), J. Steroid Biochem., 6, 1205-1209.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0052	0.0059	glycolithocholic acid	also in this range: 3alpha-hydroxy-5alpha-pregnan-20-one	Rattus norvegicus
0.007	0.0083	5alpha-dihydrotestosterone	also in this range: 3alpha-hydroxy-5alpha-androstan-17-one	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovary	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3alpha-hydroxy-5alpha-pregnan-20-one + NADP+	-	Rattus norvegicus	5alpha-pregnan-3,20-dione + NADPH	-	?
androsterone + NAD(P)+	i.e. 3alpha-hydroxy-5alpha-androstan-17-one	Rattus norvegicus	5alpha-androstan-3,17-dione + NAD(P)H	-	r

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Release 2023.1 (January 2023)