BRENDA - Enzyme Database show
show all sequences of 1.1.1.45

L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis

Dworsky, P.; Hoffmann-Ostenhof, O.; Acta Biochim. Pol. 9, 269-277 (1964)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
iodoacetate
-
Schwanniomyces occidentalis
p-chloromercuribenzoate
-
Schwanniomyces occidentalis
Phenylmercurinitrate
-
Schwanniomyces occidentalis
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1
-
NAD+
cosubstrate L-gulonate, pH 7.5 and pH 8.5
Schwanniomyces occidentalis
19
-
D-gluconate
cofactor NAD+, pH 8.5
Schwanniomyces occidentalis
55
-
L-gulonate
cofactor NAD+, pH 8.5
Schwanniomyces occidentalis
67
-
L-gulonate
cofactor NAD+, pH 7.5
Schwanniomyces occidentalis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-gulonic acid + NAD+
Schwanniomyces occidentalis
glucuronate-xylulose cycle
3-dehydro-L-gulonic acid + NADH + H+
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Schwanniomyces occidentalis
-
-
-
Purification (Commentary)
Commentary
Organism
67% yield
Schwanniomyces occidentalis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-gluconic acid + NAD+
-
286906
Schwanniomyces occidentalis
?
-
-
-
-
D-lyxonic acid + NAD+
-
286906
Schwanniomyces occidentalis
?
-
-
-
-
L-gulonic acid + NAD+
stereospecificity for L-configuration of the beta-carbon hydroxyl group
286906
Schwanniomyces occidentalis
3-dehydro-L-gulonic acid + NADH + H+
-
-
-
r
L-gulonic acid + NAD+
glucuronate-xylulose cycle
286906
Schwanniomyces occidentalis
3-dehydro-L-gulonic acid + NADH + H+
-
-
-
-
L-idonic acid + NAD+
-
286906
Schwanniomyces occidentalis
?
-
-
-
-
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
additional information
-
in solution instable, by addition of below mM of cyanide several days in the cold, minor effect through EDTA-addition
Schwanniomyces occidentalis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
oxidation of L-gulonic acid
Schwanniomyces occidentalis
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Schwanniomyces occidentalis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Schwanniomyces occidentalis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
iodoacetate
-
Schwanniomyces occidentalis
p-chloromercuribenzoate
-
Schwanniomyces occidentalis
Phenylmercurinitrate
-
Schwanniomyces occidentalis
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.1
-
NAD+
cosubstrate L-gulonate, pH 7.5 and pH 8.5
Schwanniomyces occidentalis
19
-
D-gluconate
cofactor NAD+, pH 8.5
Schwanniomyces occidentalis
55
-
L-gulonate
cofactor NAD+, pH 8.5
Schwanniomyces occidentalis
67
-
L-gulonate
cofactor NAD+, pH 7.5
Schwanniomyces occidentalis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-gulonic acid + NAD+
Schwanniomyces occidentalis
glucuronate-xylulose cycle
3-dehydro-L-gulonic acid + NADH + H+
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
67% yield
Schwanniomyces occidentalis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-gluconic acid + NAD+
-
286906
Schwanniomyces occidentalis
?
-
-
-
-
D-lyxonic acid + NAD+
-
286906
Schwanniomyces occidentalis
?
-
-
-
-
L-gulonic acid + NAD+
stereospecificity for L-configuration of the beta-carbon hydroxyl group
286906
Schwanniomyces occidentalis
3-dehydro-L-gulonic acid + NADH + H+
-
-
-
r
L-gulonic acid + NAD+
glucuronate-xylulose cycle
286906
Schwanniomyces occidentalis
3-dehydro-L-gulonic acid + NADH + H+
-
-
-
-
L-idonic acid + NAD+
-
286906
Schwanniomyces occidentalis
?
-
-
-
-
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
additional information
-
in solution instable, by addition of below mM of cyanide several days in the cold, minor effect through EDTA-addition
Schwanniomyces occidentalis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
oxidation of L-gulonic acid
Schwanniomyces occidentalis
Other publictions for EC 1.1.1.45
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
712765
Asada
Dimeric crystal structure of r ...
Oryctolagus cuniculus
J. Mol. Biol.
401
906-920
2010
-
-
1
1
4
-
-
17
-
-
1
1
-
2
-
-
1
1
-
2
-
-
4
2
1
-
-
-
1
-
-
4
-
-
-
-
-
1
4
1
4
-
-
-
-
17
-
-
1
1
-
-
-
1
-
2
-
-
4
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
695345
Asada
Crystallization and preliminar ...
Oryctolagus cuniculus
Acta Crystallogr. Sect. F
64
228-230
2008
-
-
1
1
-
-
-
-
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669147
Ishikura
Structural and functional char ...
Oryctolagus cuniculus
J. Biochem.
137
303-314
2005
-
-
1
-
6
-
5
19
1
-
3
-
-
3
-
-
1
-
-
2
2
-
5
1
-
-
-
-
1
-
-
2
-
1
2
-
-
1
2
-
6
-
2
5
-
19
1
-
3
-
-
-
-
1
-
2
2
-
5
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
286146
Goode
Accumulation of xylitol in the ...
Bos taurus, Rattus norvegicus
FEBS Lett.
395
174-178
1996
-
2
-
-
-
-
-
-
-
-
2
2
-
2
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286911
Menotti-Raymond
Further characterization of L- ...
Drosophila melanogaster
Biochim. Biophys. Acta
841
15-21
1985
-
-
-
-
-
-
-
-
-
-
1
1
-
3
-
1
1
-
-
-
2
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
-
1
1
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286910
Cannistraro
Subunit structure and kinetic ...
Drosophila melanogaster
Biochim. Biophys. Acta
569
1-5
1979
-
-
-
-
-
1
2
4
-
-
3
1
-
2
-
-
-
-
-
-
1
-
3
1
-
-
-
2
1
-
-
3
-
-
-
-
-
-
3
-
-
1
-
2
-
4
-
-
3
1
-
-
-
-
-
-
1
-
3
1
-
-
-
2
1
-
-
-
-
-
-
-
-
-
286909
Borack
-
Organ distribution of Drosophi ...
Drosophila melanogaster
Experientia
30
31
1974
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
-
2
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-
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2
-
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-
2
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1
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4
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-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286908
Koundakjian
3-Hydroxy acid dehydrogenases ...
Ovis aries
Biochem. J.
127
449-452
1972
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
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2
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-
-
2
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1
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-
-
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-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286907
Borack
Drosophila beta-L-hydroxy acid ...
Drosophila melanogaster
J. Biol. Chem.
246
5345-5350
1970
-
-
-
-
-
-
-
3
-
-
1
1
-
1
-
-
1
-
-
-
1
-
4
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
1
1
-
-
-
1
-
-
1
-
4
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
286906
Dworsky
-
L-3-Aldonic acid dehydrogenase ...
Schwanniomyces occidentalis
Acta Biochim. Pol.
9
269-277
1964
-
-
-
-
-
-
3
4
-
-
-
1
-
1
-
-
1
-
-
-
-
-
5
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
4
-
-
-
1
-
-
-
1
-
-
-
-
5
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
286905
Smiley
-
Purification and properties of ...
Sus scrofa
J. Biol. Chem.
236
357-364
1961
1
-
-
-
-
-
2
8
1
1
-
1
-
1
-
-
1
-
-
1
-
1
16
-
-
-
-
-
2
2
-
2
-
-
-
1
-
-
2
-
-
-
-
2
-
8
1
1
-
1
-
-
-
1
-
1
-
1
16
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-