Literature summary for 1.1.1.431 extracted from

Weyda, I.; Luebeck, M.; Ahring, B.K.; Luebeck, P.S.
Point mutation of the xylose reductase (XR) gene reduces xylitol accumulation and increases citric acid production in Aspergillus carbonarius (2014), J. Ind. Microbiol. Biotechnol., 41, 733-739.

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Application

Application	Comment	Organism
synthesis	in fermentation for citric acid production and xylitol accumulation by using D-xylose as the sole carbon source, a sttrain carrying mutant K274R shows a 2.8fold reduction in xylitol accumulation and 4.5fold increase in citric acid production compared to the wild-type strain	Aspergillus carbonarius

Protein Variants

Protein Variants	Comment	Organism
K274R	mutation introduced to change the specificity toward NADH. Fermentation with the mutant strain shows a 2.8fold reduction in xylitol accumulation and 4.5fold increase in citric acid production compared to the wild-type strain	Aspergillus carbonarius

Organism

Organism	UniProt	Comment	Textmining
Aspergillus carbonarius	-	-	-
Aspergillus carbonarius ITEM 5010	-	-	-

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Release 2023.1 (January 2023)