BRENDA - Enzyme Database show
show all sequences of 1.1.1.41

Novel insights into the contributions of isocitrate dehydrogenases to the Krebs cycle from patients with retinitis pigmentosa

Hartong, D.T.; Dange, M.; McGee, T.L.; Berson, E.L.; Dryja, T.P.; Colman, R.F.; Nat. Genet. 40, 1230-1234 (2008)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
L98P
the mutation is associated with retinitis pigmentosa
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O43837
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
lymphoblast
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
DL-isocitrate + NAD+
-
700359
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
L98P
the mutation is associated with retinitis pigmentosa
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
lymphoblast
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
DL-isocitrate + NAD+
-
700359
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
Other publictions for EC 1.1.1.41
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
723607
Wang
Isocitrate dehydrogenase from ...
Streptococcus mutans
PLoS ONE
8
e58918
2013
-
-
1
-
4
-
5
10
-
2
1
1
-
2
-
1
1
-
-
-
-
-
2
1
1
1
2
10
1
1
-
3
-
-
-
-
-
1
3
-
4
-
-
5
-
10
-
2
1
1
-
-
1
1
-
-
-
-
2
1
1
1
2
10
1
1
-
-
-
2
2
-
10
10
721381
Yang
Characterization of the mitoch ...
Rhodotorula toruloides, Rhodotorula toruloides AS 2.1389
Appl. Microbiol. Biotechnol.
94
1095-1105
2012
-
-
1
-
-
-
-
-
3
-
-
4
-
9
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
2
-
-
-
-
-
-
-
4
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
721433
McAlister-Henn
Ligand binding and structural ...
Saccharomyces cerevisiae
Arch. Biochem. Biophys.
519
112-117
2012
1
-
-
-
7
-
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
7
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722295
Wang
Biochemical and molecular char ...
Zymomonas mobilis, Zymomonas mobilis ATCC10988
FEMS Microbiol. Lett.
327
134-141
2012
-
-
1
-
-
-
5
4
-
4
2
2
-
4
-
-
1
-
-
-
-
-
6
1
1
1
1
4
2
1
-
2
-
-
-
-
-
1
2
-
-
-
-
5
-
4
-
4
2
2
-
-
-
1
-
-
-
-
6
1
1
1
1
4
2
1
-
-
-
1
1
-
4
4
721650
Lin
Basis for half-site ligand bin ...
Saccharomyces cerevisiae
Biochemistry
50
8241-8250
2011
2
-
1
-
4
-
1
18
-
1
2
1
-
2
-
-
1
-
-
-
-
-
1
2
1
-
-
-
1
-
-
1
-
-
-
2
-
1
1
-
4
-
-
1
-
18
-
1
2
1
-
-
-
1
-
-
-
-
1
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
712440
Dange
Each conserved active site tyr ...
Homo sapiens
J. Biol. Chem.
285
20520-20525
2010
1
-
1
-
7
-
-
12
2
1
-
1
-
2
-
-
1
-
-
-
-
-
2
1
1
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
7
-
-
-
-
12
2
1
-
1
-
-
-
1
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
713076
Sienkiewicz-Porzucek
Mild reductions in mitochondri ...
Solanum lycopersicum
Mol. Plant
3
156-173
2010
-
-
1
-
1
-
-
-
2
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
713380
Zhang
Genetic analysis of central ca ...
Zea mays
PLoS ONE
5
e9991
2010
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
696358
Garcia
Disulfide bond formation in ye ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Biochemistry
48
8869-8878
2009
-
-
1
-
2
-
1
-
-
-
2
-
-
8
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
-
1
-
-
-
-
2
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712180
Kang
Mutational analysis of IDH1 co ...
Homo sapiens
Int. J. Cancer
125
353-355
2009
-
-
1
-
7
-
-
-
-
-
-
1
-
1
-
-
-
-
-
20
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
1
-
-
-
-
-
20
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684713
Lin
Suppression of metabolic defec ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Arch. Biochem. Biophys.
474
205-212
2008
-
-
-
-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687692
Taylor
Allosteric motions in structur ...
Saccharomyces cerevisiae
J. Biol. Chem.
283
10872-10880
2008
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689940
Imada
Structure and quantum chemical ...
Acidithiobacillus thiooxidans
Proteins
70
63-71
2008
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695342
Hatzopoulos
Cloning, expression, purificat ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. F
64
1139-1142
2008
-
-
1
1
-
-
-
-
-
-
4
-
-
139
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700359
Hartong
Novel insights into the contri ...
Homo sapiens
Nat. Genet.
40
1230-1234
2008
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684749
Stokke
Biochemical characterization o ...
Methylococcus capsulatus
Arch. Microbiol.
187
361-370
2007
-
-
1
-
-
-
-
1
-
-
2
-
-
5
-
-
1
-
-
-
-
-
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
685154
Bzymek
Role of alpha-Asp181, beta-Asp ...
Homo sapiens
Biochemistry
46
5391-5397
2007
1
-
-
-
3
-
-
8
-
1
1
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
8
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685719
Kanamasa
-
Isocitrate dehydrogenase and i ...
Eremothecium gossypii
Biotechnol. Bioprocess Eng.
12
92-99
2007
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689578
Lemaitre
NAD-dependent isocitrate dehyd ...
Arabidopsis thaliana
Plant Physiol.
144
1546-1558
2007
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667098
Hu
-
Crystallization and preliminar ...
Saccharomyces cerevisiae
Acta Crystallogr. Sect. F
F62
709
2006
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667332
Hu
Novel allosteric properties pr ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Arch. Biochem. Biophys.
453
207-216
2006
-
-
1
-
9
-
-
-
-
-
3
-
-
10
-
-
1
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
12
-
-
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
4
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669465
Hu
Physiological consequences of ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
J. Biol. Chem.
281
16935-16942
2006
-
-
-
-
6
-
-
-
-
1
3
-
-
8
-
-
1
-
-
-
-
-
2
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
1
3
-
-
-
-
1
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
669477
Soundar
Identification of Mn2+-binding ...
Homo sapiens
J. Biol. Chem.
281
21073-21081
2006
-
-
1
-
7
-
-
12
-
3
2
-
-
4
-
-
1
-
-
-
6
-
2
1
-
-
-
18
-
-
-
2
-
-
-
-
-
1
2
-
7
-
-
-
-
12
-
3
2
-
-
-
-
1
-
-
6
-
2
1
-
-
-
18
-
-
-
-
-
-
-
-
-
-
670547
Lemaitre
Expression analysis of Arabido ...
Arabidopsis thaliana
Plant Cell Physiol.
47
634-643
2006
-
-
1
-
-
-
-
-
1
-
11
-
-
10
-
-
-
-
-
23
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
5
-
11
-
-
-
-
-
-
87
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670847
Kalinina
Amino acid residues that deter ...
Escherichia coli
Proteins
64
1001-1009
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660907
Miyazaki
Bifunctional isocitrate-homois ...
Pyrococcus horikoshii
Biochem. Biophys. Res. Commun.
331
341-346
2005
-
-
1
-
-
-
-
3
-
2
-
-
-
3
-
-
1
-
1
-
1
-
2
-
-
-
-
3
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
3
-
2
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
667647
Anderson
Analysis of interactions with ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Biochemistry
44
16776-16784
2005
1
-
-
-
1
-
1
-
2
-
-
-
-
8
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
1
-
-
2
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670158
Watanabe
Elucidation of stability deter ...
Azotobacter vinelandii, Colwellia maris
Microbiology
151
1083-1094
2005
-
-
2
-
-
-
-
4
-
4
2
-
-
5
-
-
2
-
-
-
2
-
2
2
2
-
-
4
-
-
-
2
-
-
-
-
-
2
2
-
-
-
-
-
-
4
-
4
2
-
-
-
-
2
-
-
2
-
2
2
2
-
-
4
-
-
-
-
-
-
-
-
-
-
670544
Abiko
Localization of NAD-isocitrate ...
Oryza sativa
Plant Cell Physiol.
46
1724-1734
2005
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670805
Rodriguez-Arnedo
Complete reversal of coenzyme ...
Escherichia coli
Protein J.
24
259-266
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654783
Morgunov
Regulation of NAD(+)-dependent ...
Yarrowia lipolytica
Biochemistry
69
1391-1398
2004
1
-
-
-
-
1
3
2
-
1
2
2
-
3
-
-
1
-
-
-
4
-
2
1
1
-
-
-
1
-
-
1
1
-
-
1
-
-
1
-
-
1
-
3
1
2
-
1
2
2
-
-
-
1
-
-
4
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
657111
Lin
Characterization of a mutation ...
Arabidopsis thaliana, Arabidopsis thaliana Landsberg
Plant Sci.
166
983-988
2004
-
-
1
-
1
-
-
-
1
1
-
2
-
2
-
-
1
-
-
6
2
-
4
1
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
1
-
2
-
-
-
1
-
6
2
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
654843
Igamberdiev
Regulation of NAD- and NADP-de ...
Pisum sativum
Biochim. Biophys. Acta
1606
117-125
2003
1
-
-
-
-
-
3
2
1
1
-
1
-
2
-
-
1
-
-
1
2
1
2
-
-
-
-
-
1
-
-
1
2
-
-
1
-
-
1
-
-
-
-
3
2
2
1
1
-
1
-
-
-
1
-
1
2
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
654914
Pinheiro de Carvalho
-
Effect of metabolites of gamma ...
Pisum sativum, Zea mays
Biol. Bull.
30
236-242
2003
1
-
-
-
-
-
7
-
1
1
-
2
-
2
-
-
-
-
-
2
2
-
2
-
2
-
-
-
-
-
-
2
-
-
-
1
-
-
2
-
-
-
-
7
-
-
1
1
-
2
-
-
-
-
-
2
2
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
656118
Lin
Homologous binding sites in ye ...
Saccharomyces cerevisiae
J. Biol. Chem.
278
12864-12872
2003
1
-
1
-
4
-
-
1
1
1
1
1
-
2
-
-
1
-
-
-
-
-
2
1
1
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
4
-
-
-
-
1
1
1
1
1
-
-
-
1
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
656189
Soundar
Evaluation by mutagenesis of t ...
Homo sapiens
J. Biol. Chem.
278
52146-52153
2003
1
-
1
-
3
-
-
11
-
1
1
1
-
5
-
-
1
1
-
-
3
-
1
1
1
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
3
-
-
-
-
11
-
1
1
1
-
-
-
1
-
-
3
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
654652
Anderson
Effect of AMP on mRNA binding ...
Saccharomyces cerevisiae
Biochemistry
41
7065-7073
2002
1
-
-
-
-
-
1
-
2
1
-
2
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
-
2
1
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
655607
Inoue
Biochemical and molecular char ...
Acidithiobacillus thiooxidans, Acidithiobacillus thiooxidans ON107
FEMS Microbiol. Lett.
214
127-132
2002
-
-
1
-
-
-
-
3
-
1
2
2
-
4
-
-
1
-
-
-
1
-
2
1
1
-
2
2
1
1
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
3
-
1
2
2
-
-
-
1
-
-
1
-
2
1
1
-
2
2
1
1
-
-
-
-
-
-
-
-
656052
Lin
Isocitrate binding at two func ...
Saccharomyces cerevisiae
J. Biol. Chem.
277
22475-22483
2002
1
-
1
-
6
-
-
1
-
1
-
1
-
2
-
-
1
-
-
-
-
1
2
2
1
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
6
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
1
2
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
721450
Steen
Identification of cofactor dis ...
Pyrococcus furiosus
Arch. Microbiol.
178
297-300
2002
-
-
-
-
2
-
-
6
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
1
1
3
6
1
-
-
2
-
-
-
-
-
-
2
-
2
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
1
3
6
1
-
-
-
-
-
-
-
6
6
286771
Panisko
Subunit interactions of yeast ...
Saccharomyces cerevisiae
J. Biol. Chem.
276
1204-1210
2001
-
-
-
-
-
-
-
-
1
1
2
1
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
2
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727835
Steen
Comparison of isocitrate dehyd ...
Pyrococcus furiosus
J. Biol. Chem.
276
43924-43931
2001
-
-
-
-
-
-
-
1
-
-
2
-
-
6
-
-
1
-
-
-
-
-
1
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
1
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
286772
Anderson
Allosteric inhibition of NAD+- ...
Saccharomyces cerevisiae
Biochemistry
39
5623-5629
2000
1
-
-
-
-
-
1
-
1
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286769
Kim
Identification and functional ...
Homo sapiens
J. Biol. Chem.
274
36866-36875
1999
-
-
1
-
-
-
-
-
1
-
-
1
-
5
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286773
Martinez-Rivas
Purification and characterizat ...
Chlamydomonas reinhardtii
Plant Physiol.
118
249-255
1998
-
-
-
-
-
-
8
-
-
-
2
1
-
2
-
-
1
-
-
-
1
-
1
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
8
-
-
-
-
2
1
-
-
-
1
-
-
1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
286774
McIntosh
-
Partial purification and chara ...
Pisum sativum
Plant Sci.
129
9-20
1997
-
-
-
-
-
-
1
1
1
2
1
1
-
1
-
-
1
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
1
1
2
1
1
-
-
-
1
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286775
Huang
Identification of the subunits ...
Sus scrofa
Arch. Biochem. Biophys.
348
207-218
1997
1
-
-
-
-
-
-
-
-
2
-
1
-
2
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286776
Alvarez-Villafane
Two NAD+-dependent isocitrate ...
Phycomyces blakesleeanus
Biochemistry
35
4741-4752
1996
1
-
-
-
-
1
1
-
-
2
2
1
-
1
-
-
1
-
-
-
2
-
1
1
-
1
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
1
-
1
-
-
-
2
2
1
-
-
-
1
-
-
2
-
1
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
286777
Hurley
Determinants of cofactor speci ...
Escherichia coli
Biochemistry
35
5670-5678
1996
-
-
-
1
1
-
-
4
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
1
-
-
-
-
4
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663920
Mitchell
-
Identification of a multienzym ...
Pseudomonas aeruginosa
Biochem. J.
313
769-774
1996
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286770
Gabriel
Kinetic regulation of yeast NA ...
Saccharomyces cerevisiae
Biochemistry
30
2594-2599
1991
-
-
-
-
-
-
16
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
16
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286767
Rutter
Regulation of NAD+-linked isoc ...
Rattus norvegicus
Biochem. J.
252
181-189
1988
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
286764
Gabriel
Inhibition and activation of b ...
Bos taurus
Arch. Biochem. Biophys.
240
128-134
1985
-
-
-
-
-
-
3
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286765
Gabriel
NAD-specific isocitrate dehydr ...
Bos taurus
Biochem. J.
229
817-822
1985
-
-
-
-
-
-
6
-
-
-
-
1
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286766
Evans
-
The role of the mitochondrial ...
Rhodotorula toruloides
Can. J. Microbiol.
31
845-850
1985
-
-
-
-
-
-
6
-
1
-
1
1
-
1
-
-
1
-
-
-
1
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
6
-
-
1
-
1
1
-
-
-
1
-
-
1
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
286762
Gabriel
Inhibition of bovine heart NAD ...
Bos taurus
Biochemistry
23
2773-2778
1984
-
-
-
-
-
-
2
-
1
1
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286763
Bulos
Calcium inhibition of the NAD+ ...
Phormia regina
J. Biol. Chem.
259
10232-10237
1984
-
-
-
-
-
-
2
-
-
1
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
1
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286768
Gabriel
Citrate activation of NAD-spec ...
Bos taurus
J. Biol. Chem.
259
1622-1628
1984
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286761
Tezuka
Isolation and characterization ...
Solanum tuberosum
Plant Physiol.
72
959-963
1982
-
-
-
-
-
-
2
-
2
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
2
-
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
286758
Willson
The activation of ox-brain NAD ...
Bos taurus
Eur. J. Biochem.
113
477-483
1981
-
-
-
-
-
-
1
-
-
3
-
1
-
1
-
-
1
-
-
1
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
3
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
286759
Ehrlich
Re-evaluation of molecular wei ...
Sus scrofa
J. Biol. Chem.
256
10560-10564
1981
-
-
-
-
-
-
-
-
-
-
2
1
-
2
-
-
1
-
-
2
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
1
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286760
Gabriel
Specific site inhibitors of NA ...
Bos taurus
J. Biol. Chem.
257
8021-8029
1981
-
-
-
-
-
-
5
1
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
1
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286756
Hoffmann
Regulation of NAD+- and NADP+- ...
Pseudomonas sp., Pseudomonas sp. W 6
Z. Allg. Mikrobiol.
20
399-404
1980
-
-
-
-
-
-
2
1
-
-
-
2
-
4
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
2
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286757
Willson
The effect of pH on the allost ...
Bos taurus
Eur. J. Biochem.
109
411-416
1980
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
1
-
-
-
1
1
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
1
1
-
-
-
-
-
-
-
286755
Ramachandran
Evidence for the presence of t ...
Sus scrofa
Proc. Natl. Acad. Sci. USA
75
252-255
1978
-
-
-
-
-
-
-
-
-
-
3
1
-
2
-
1
1
-
-
2
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
1
-
-
1
1
-
2
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286754
Nabeshima
-
Partial purification and some ...
Candida tropicalis
Agric. Biol. Chem.
41
509-516
1977
-
-
-
-
-
-
1
-
1
-
-
1
-
1
-
-
1
-
-
-
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286753
Alp
Activities of citrate synthase ...
Lepas anatifera, Locusta sp., Oryctes rhinoceros, Ovis aries, Periplaneta americana, Sarcophaga barbata, waterbug
Biochem. J.
154
689-700
1976
-
-
-
-
-
7
7
-
-
-
-
7
-
10
-
-
-
-
-
7
-
-
7
-
7
-
-
-
8
-
-
7
-
-
-
-
-
-
7
-
-
7
-
7
-
-
-
-
-
7
-
-
-
-
-
7
-
-
7
-
7
-
-
-
8
-
-
-
-
-
-
-
-
-
286751
Cohen
Role of manganous ion in the k ...
Sus scrofa
Eur. J. Biochem.
47
35-45
1974
-
-
-
-
-
-
-
-
-
4
-
1
-
1
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
1
-
-
-
1
-
1
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
286752
Silinski
The kinetics of NAD-linked iso ...
Bos taurus
Biochim. Biophys. Acta
370
1-25
1974
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
1
1
-
1
1
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
1
1
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
286750
Glaeser
NADP- und NAD-spezifische dehy ...
Cupriavidus necator
Arch. Microbiol.
86
327-337
1972
-
-
-
-
-
-
5
2
-
-
-
1
-
2
-
-
1
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
2
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
286749
Plaut
-
Isocitrate dehydrogenase ...
Aspergillus niger, Bos taurus, Cavia porcellus, Columba livia, Homo sapiens, Pisum sativum, Rattus norvegicus, Saccharomyces cerevisiae
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
7
105-126
1963
1
-
-
-
-
-
10
2
8
7
-
8
-
8
-
-
-
-
-
7
-
-
8
-
-
-
-
-
3
2
-
8
-
-
-
1
-
-
8
-
-
-
-
10
-
2
8
7
-
8
-
-
-
-
-
7
-
-
8
-
-
-
-
-
3
2
-
-
-
-
-
-
-
-