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Literature summary for 1.1.1.41 extracted from

  • Gabriel, J.L.; Plaut, G.W.E.
    Kinetic regulation of yeast NAD-specific isocitrate dehydrogenase by citrate (1991), Biochemistry, 30, 2594-2599.
    View publication on PubMed
Search for more literature for 1.1.1.41

Inhibitors

Inhibitors Comment Organism Structure
beta-mercapto-alpha-ketoglutarate inhibition in presence and absence of AMP, competitive inhibition Saccharomyces cerevisiae
citrate with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, citrate is an activator Saccharomyces cerevisiae
D,L-hibiscusate with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, D,L-hibiscusate is an activator Saccharomyces cerevisiae
D,L-threo-alpha-methylisocitrate inhibition in presence and absence of AMP, competitive inhibition Saccharomyces cerevisiae
D-malate inhibition only in absence of AMP Saccharomyces cerevisiae
D-Tartrate inhibition only in absence of AMP Saccharomyces cerevisiae
Fluorocitrate with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, fluorocitrate is an activator Saccharomyces cerevisiae
fumarate inhibition only in absence of AMP Saccharomyces cerevisiae
homocitrate inhibition only in absence of AMP Saccharomyces cerevisiae
L-garciniate inhibition in presence and absence of AMP Saccharomyces cerevisiae
L-hibiscusate with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, L-hibiscusate is an activator Saccharomyces cerevisiae
L-malate inhibition only in absence of AMP, competitive inhibition Saccharomyces cerevisiae
L-Tartrate inhibition only in absence of AMP Saccharomyces cerevisiae
Maleate inhibition only in absence of AMP Saccharomyces cerevisiae
malonate inhibition only in absence of AMP Saccharomyces cerevisiae
succinate inhibition only in absence of AMP Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Saccharomyces cerevisiae
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
 Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae