BRENDA - Enzyme Database show
show all sequences of 1.1.1.4

Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)-2,3-butanediol production

Bai, F.; Dai, L.; Fan, J.; Truong, N.; Rao, B.; Zhang, L.; Shen, Y.; J. Ind. Microbiol. Biotechnol. 42, 779-786 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Serratia marcescens
expressed in Serratia marcescens MG1 slaC mutant strain
Bacillus subtilis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(R)-acetoin + NADH + H+
Bacillus subtilis
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R)-acetoin + NADH + H+
Serratia marcescens
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R)-acetoin + NADH + H+
Bacillus subtilis 168
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R)-acetoin + NADH + H+
Serratia marcescens MG1
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Bacillus subtilis
-
(R)-acetoin + NADH + H+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Serratia marcescens
-
(R)-acetoin + NADH + H+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Bacillus subtilis 168
-
(R)-acetoin + NADH + H+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Serratia marcescens MG1
-
(R)-acetoin + NADH + H+
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus subtilis
-
-
-
Bacillus subtilis 168
-
-
-
Serratia marcescens
-
-
-
Serratia marcescens MG1
-
-
-
Purification (Commentary)
Commentary
Organism
His-Trap column chromatography
Bacillus subtilis
His-Trap column chromatography
Serratia marcescens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-acetoin + NADH + H+
-
738800
Bacillus subtilis
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R)-acetoin + NADH + H+
-
738800
Serratia marcescens
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R)-acetoin + NADH + H+
-
738800
Bacillus subtilis 168
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R)-acetoin + NADH + H+
-
738800
Serratia marcescens MG1
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Bacillus subtilis
(R)-acetoin + NADH + H+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Serratia marcescens
(R)-acetoin + NADH + H+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Bacillus subtilis 168
(R)-acetoin + NADH + H+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Serratia marcescens MG1
(R)-acetoin + NADH + H+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Bacillus subtilis
(3S)-acetoin + NAD+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Serratia marcescens
(3S)-acetoin + NAD+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Bacillus subtilis 168
(3S)-acetoin + NAD+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Serratia marcescens MG1
(3S)-acetoin + NAD+
-
-
-
r
Subunits
Subunits
Commentary
Organism
?
x * 35000, SDS-PAGE
Bacillus subtilis
?
x * 35000, SDS-PAGE
Serratia marcescens
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Serratia marcescens
NAD+
-
Bacillus subtilis
NADH
-
Bacillus subtilis
NADH
-
Serratia marcescens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Serratia marcescens
expressed in Serratia marcescens MG1 slaC mutant strain
Bacillus subtilis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Serratia marcescens
NAD+
-
Bacillus subtilis
NADH
-
Bacillus subtilis
NADH
-
Serratia marcescens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(R)-acetoin + NADH + H+
Bacillus subtilis
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R)-acetoin + NADH + H+
Serratia marcescens
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R)-acetoin + NADH + H+
Bacillus subtilis 168
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R)-acetoin + NADH + H+
Serratia marcescens MG1
-
(R,R)-butane-2,3-diol + NAD+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Bacillus subtilis
-
(R)-acetoin + NADH + H+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Serratia marcescens
-
(R)-acetoin + NADH + H+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Bacillus subtilis 168
-
(R)-acetoin + NADH + H+
-
-
r
(R,R)-butane-2,3-diol + NAD+
Serratia marcescens MG1
-
(R)-acetoin + NADH + H+
-
-
r
Purification (Commentary) (protein specific)
Commentary
Organism
His-Trap column chromatography
Bacillus subtilis
His-Trap column chromatography
Serratia marcescens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-acetoin + NADH + H+
-
738800
Bacillus subtilis
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R)-acetoin + NADH + H+
-
738800
Serratia marcescens
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R)-acetoin + NADH + H+
-
738800
Bacillus subtilis 168
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R)-acetoin + NADH + H+
-
738800
Serratia marcescens MG1
(R,R)-butane-2,3-diol + NAD+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Bacillus subtilis
(R)-acetoin + NADH + H+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Serratia marcescens
(R)-acetoin + NADH + H+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Bacillus subtilis 168
(R)-acetoin + NADH + H+
-
-
-
r
(R,R)-butane-2,3-diol + NAD+
-
738800
Serratia marcescens MG1
(R)-acetoin + NADH + H+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Bacillus subtilis
(3S)-acetoin + NAD+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Serratia marcescens
(3S)-acetoin + NAD+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Bacillus subtilis 168
(3S)-acetoin + NAD+
-
-
-
r
dicaetyl + NADH + H+
-
738800
Serratia marcescens MG1
(3S)-acetoin + NAD+
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 35000, SDS-PAGE
Bacillus subtilis
?
x * 35000, SDS-PAGE
Serratia marcescens
Other publictions for EC 1.1.1.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737512
Rados
Stereospecificity of Corynebac ...
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC13032
Appl. Microbiol. Biotechnol.
100
10573-10583
2016
-
-
1
-
-
-
-
4
-
-
-
4
-
9
-
-
1
-
-
-
-
-
10
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
4
-
-
-
4
-
-
-
1
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
4
4
737519
de Oliveira
Synthetic operon for (R,R)-2,3 ...
Bacillus subtilis, Bacillus subtilis WN1038
Appl. Microbiol. Biotechnol.
100
719-728
2016
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738345
Ge
-
Contracted but effective: Prod ...
Bacillus licheniformis, Bacillus licheniformis MW3
Green Chem.
18
4693-4703
2016
-
-
1
-
-
-
-
-
-
-
-
4
-
2
-
-
1
-
-
-
14
-
20
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
1
-
-
14
-
20
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739694
Bae
Efficient production of acetoi ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Sci. Rep.
6
27667
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
46
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737847
Kang
Enhanced production of 2,3-but ...
Bacillus sp., Bacillus sp. BRC1
Bioprocess Biosyst. Eng.
38
299-305
2015
-
-
1
-
-
-
-
4
-
1
-
2
-
2
-
-
1
-
-
-
-
-
14
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
4
-
1
-
2
-
-
-
1
-
-
-
-
14
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
738800
Bai
Engineered Serratia marcescens ...
Bacillus subtilis 168, Bacillus subtilis, Serratia marcescens, Serratia marcescens MG1
J. Ind. Microbiol. Biotechnol.
42
779-786
2015
-
-
2
-
-
-
-
-
-
-
-
8
-
77
-
-
2
-
-
-
-
-
12
2
-
-
-
-
-
-
-
4
-
-
-
-
-
2
4
-
-
-
-
-
-
-
-
-
-
8
-
-
-
2
-
-
-
-
12
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738953
Zhao
Identification and characteriz ...
Corynebacterium crenatum, Corynebacterium crenatum SYPA5-5
Lett. Appl. Microbiol.
61
573-579
2015
-
-
1
-
-
-
4
-
-
5
-
-
-
5
-
-
1
-
-
-
-
-
-
1
1
-
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
-
-
-
-
739127
Yu
Characterization of a (2R,3R)- ...
Rhodococcus erythropolis, Rhodococcus erythropolis WZ010
Molecules
20
7156-7173
2015
1
-
1
-
-
-
15
4
-
3
1
3
-
4
-
-
1
-
-
-
-
-
19
1
2
-
1
4
2
1
-
2
-
-
-
1
-
1
2
-
-
-
-
15
-
4
-
3
1
3
-
-
-
1
-
-
-
-
19
1
2
-
1
4
2
1
-
-
-
-
-
-
4
4
739571
Maddock
Substitutions at the cofactor ...
Clostridium autoethanogenum
Protein Eng. Des. Sel.
28
251-258
2015
-
-
1
-
7
-
-
21
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
21
-
-
-
2
-
-
-
-
-
1
2
-
7
-
-
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
21
-
-
-
-
-
-
-
-
21
21
737501
Koepke
Reconstruction of an acetogeni ...
Clostridium autoethanogenum
Appl. Environ. Microbiol.
80
3394-3403
2014
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
5
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
5
-
-
-
-
-
-
-
-
5
5
738472
Cui
Utilization of excess NADH in ...
Bacillus licheniformis
J. Appl. Microbiol.
117
690-698
2014
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738637
Wang
Glycerol dehydrogenase plays a ...
Klebsiella pneumoniae, Klebsiella pneumoniae ATCC 25955
J. Biol. Chem.
289
6080-6090
2014
-
-
1
-
-
-
-
8
-
-
-
2
-
2
-
-
1
-
-
-
-
-
10
1
-
-
-
8
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
8
-
-
-
2
-
-
-
1
-
-
-
-
10
1
-
-
-
8
-
-
-
-
1
-
-
1
7
7
738878
Kochius
-
Enantioselective enzymatic syn ...
Haloarcula marismortui
J. Mol. Catal. B
103
61-66
2014
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738880
Hao
-
Biochemical characterization o ...
Bacillus subtilis, Bacillus subtilis 168
J. Mol. Catal. B
109
184-190
2014
-
-
-
-
1
-
-
-
-
-
-
4
-
72
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722559
Gao
A 2,3-butanediol dehydrogenase ...
Paenibacillus polymyxa, Paenibacillus polymyxa ZJ-9
J. Basic Microbiol.
53
733-741
2013
-
-
1
-
-
-
-
6
-
-
2
-
-
3
-
-
1
-
-
1
1
-
4
1
1
-
-
-
2
-
-
3
-
-
-
-
-
1
3
-
-
-
-
-
-
6
-
-
2
-
-
-
-
1
-
1
1
-
4
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
737366
Miao
Crystallization and preliminar ...
Bacillus coagulans, Bacillus coagulans 2-6
Acta Crystallogr. Sect. F
69
1140-1142
2013
-
-
1
1
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Properties of 2,3-butanediol d ...
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