BRENDA - Enzyme Database show
show all sequences of 1.1.1.4

Bacterial 2,3-butanediol dehydrogenases

Hhn-Bentz, H.; Radler, F.; Arch. Microbiol. 116, 197-203 (1978)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Borate buffer
-
Paenibacillus polymyxa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.1
-
NADH
-
Paenibacillus polymyxa
0.2
-
NAD+
-
Paenibacillus polymyxa
0.53
-
acetoin
-
Paenibacillus polymyxa
3.3
-
D-(-)2,3-butanediol
-
Paenibacillus polymyxa
6.25
-
meso-2,3-butanediol
-
Paenibacillus polymyxa
38
-
1,2-propanediol
-
Paenibacillus polymyxa
87
-
diacetyl
-
Paenibacillus polymyxa
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
no requirement
Aeromonas hydrophila
additional information
no requirement
Bacillus subtilis
additional information
no requirement
Gluconobacter oxydans
additional information
no requirement
Paenibacillus polymyxa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
100000
107000
gel filtration
Paenibacillus polymyxa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aeromonas hydrophila
-
-
-
Bacillus subtilis
-
-
-
Gluconobacter oxydans
-
-
-
Paenibacillus polymyxa
-
-
-
Purification (Commentary)
Commentary
Organism
-
Paenibacillus polymyxa
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.21
-
-
Paenibacillus polymyxa
0.6
-
-
Gluconobacter oxydans
Storage Stability
Storage Stability
Organism
stable at -18C
Paenibacillus polymyxa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Bacillus subtilis
acetoin + NADH
-
246407
Bacillus subtilis
r
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Paenibacillus polymyxa
acetoin + NADH
-
246407
Paenibacillus polymyxa
r
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Aeromonas hydrophila
acetoin + NADH
-
246407
Aeromonas hydrophila
r
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Gluconobacter oxydans
acetoin + NADH
-
246407
Gluconobacter oxydans
r
acetoin + NADH + H+
-
246407
Bacillus subtilis
2,3-butanediol + NAD+
-
246407
Bacillus subtilis
r
acetoin + NADH + H+
-
246407
Paenibacillus polymyxa
2,3-butanediol + NAD+
-
246407
Paenibacillus polymyxa
r
acetoin + NADH + H+
-
246407
Aeromonas hydrophila
2,3-butanediol + NAD+
-
246407
Aeromonas hydrophila
r
acetoin + NADH + H+
-
246407
Gluconobacter oxydans
2,3-butanediol + NAD+
-
246407
Gluconobacter oxydans
r
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
60
62
-
Gluconobacter oxydans
60
62
-
Paenibacillus polymyxa
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
60
65
-
Paenibacillus polymyxa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
acetoin reduction
Gluconobacter oxydans
9
-
D(-)-2,3-butanediol oxidation
Gluconobacter oxydans
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
7
7.6
-
Paenibacillus polymyxa
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Aeromonas hydrophila
NAD+
-
Gluconobacter oxydans
NAD+
-
Paenibacillus polymyxa
NAD+
-
Bacillus subtilis
NADH
-
Aeromonas hydrophila
NADH
-
Gluconobacter oxydans
NADH
-
Paenibacillus polymyxa
NADH
-
Bacillus subtilis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Aeromonas hydrophila
NAD+
-
Gluconobacter oxydans
NAD+
-
Paenibacillus polymyxa
NAD+
-
Bacillus subtilis
NADH
-
Aeromonas hydrophila
NADH
-
Gluconobacter oxydans
NADH
-
Paenibacillus polymyxa
NADH
-
Bacillus subtilis
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Borate buffer
-
Paenibacillus polymyxa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.1
-
NADH
-
Paenibacillus polymyxa
0.2
-
NAD+
-
Paenibacillus polymyxa
0.53
-
acetoin
-
Paenibacillus polymyxa
3.3
-
D-(-)2,3-butanediol
-
Paenibacillus polymyxa
6.25
-
meso-2,3-butanediol
-
Paenibacillus polymyxa
38
-
1,2-propanediol
-
Paenibacillus polymyxa
87
-
diacetyl
-
Paenibacillus polymyxa
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
no requirement
Aeromonas hydrophila
additional information
no requirement
Bacillus subtilis
additional information
no requirement
Gluconobacter oxydans
additional information
no requirement
Paenibacillus polymyxa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
100000
107000
gel filtration
Paenibacillus polymyxa
Purification (Commentary) (protein specific)
Commentary
Organism
-
Paenibacillus polymyxa
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.21
-
-
Paenibacillus polymyxa
0.6
-
-
Gluconobacter oxydans
Storage Stability (protein specific)
Storage Stability
Organism
stable at -18C
Paenibacillus polymyxa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Bacillus subtilis
acetoin + NADH
-
246407
Bacillus subtilis
r
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Paenibacillus polymyxa
acetoin + NADH
-
246407
Paenibacillus polymyxa
r
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Aeromonas hydrophila
acetoin + NADH
-
246407
Aeromonas hydrophila
r
2,3-butanediol + NAD+
D(-)-2,3-butandiol
246407
Gluconobacter oxydans
acetoin + NADH
-
246407
Gluconobacter oxydans
r
acetoin + NADH + H+
-
246407
Bacillus subtilis
2,3-butanediol + NAD+
-
246407
Bacillus subtilis
r
acetoin + NADH + H+
-
246407
Paenibacillus polymyxa
2,3-butanediol + NAD+
-
246407
Paenibacillus polymyxa
r
acetoin + NADH + H+
-
246407
Aeromonas hydrophila
2,3-butanediol + NAD+
-
246407
Aeromonas hydrophila
r
acetoin + NADH + H+
-
246407
Gluconobacter oxydans
2,3-butanediol + NAD+
-
246407
Gluconobacter oxydans
r
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
60
62
-
Gluconobacter oxydans
60
62
-
Paenibacillus polymyxa
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
60
65
-
Paenibacillus polymyxa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
acetoin reduction
Gluconobacter oxydans
9
-
D(-)-2,3-butanediol oxidation
Gluconobacter oxydans
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
7
7.6
-
Paenibacillus polymyxa
Other publictions for EC 1.1.1.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737512
Rados
Stereospecificity of Corynebac ...
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC13032
Appl. Microbiol. Biotechnol.
100
10573-10583
2016
-
-
1
-
-
-
-
4
-
-
-
4
-
9
-
-
1
-
-
-
-
-
10
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
4
-
-
-
4
-
-
-
1
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
4
4
737519
de Oliveira
Synthetic operon for (R,R)-2,3 ...
Bacillus subtilis, Bacillus subtilis WN1038
Appl. Microbiol. Biotechnol.
100
719-728
2016
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738345
Ge
-
Contracted but effective: Prod ...
Bacillus licheniformis, Bacillus licheniformis MW3
Green Chem.
18
4693-4703
2016
-
-
1
-
-
-
-
-
-
-
-
4
-
2
-
-
1
-
-
-
14
-
20
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
1
-
-
14
-
20
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739694
Bae
Efficient production of acetoi ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Sci. Rep.
6
27667
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
46
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737847
Kang
Enhanced production of 2,3-but ...
Bacillus sp., Bacillus sp. BRC1
Bioprocess Biosyst. Eng.
38
299-305
2015
-
-
1
-
-
-
-
4
-
1
-
2
-
2
-
-
1
-
-
-
-
-
14
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
4
-
1
-
2
-
-
-
1
-
-
-
-
14
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
738800
Bai
Engineered Serratia marcescens ...
Bacillus subtilis 168, Bacillus subtilis, Serratia marcescens, Serratia marcescens MG1
J. Ind. Microbiol. Biotechnol.
42
779-786
2015
-
-
2
-
-
-
-
-
-
-
-
8
-
77
-
-
2
-
-
-
-
-
12
2
-
-
-
-
-
-
-
4
-
-
-
-
-
2
4
-
-
-
-
-
-
-
-
-
-
8
-
-
-
2
-
-
-
-
12
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738953
Zhao
Identification and characteriz ...
Corynebacterium crenatum, Corynebacterium crenatum SYPA5-5
Lett. Appl. Microbiol.
61
573-579
2015
-
-
1
-
-
-
4
-
-
5
-
-
-
5
-
-
1
-
-
-
-
-
-
1
1
-
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
2
-
-
-
-
-
-
-
-
-
739127
Yu
Characterization of a (2R,3R)- ...
Rhodococcus erythropolis, Rhodococcus erythropolis WZ010
Molecules
20
7156-7173
2015
1
-
1
-
-
-
15
4
-
3
1
3
-
4
-
-
1
-
-
-
-
-
19
1
2
-
1
4
2
1
-
2
-
-
-
1
-
1
2
-
-
-
-
15
-
4
-
3
1
3
-
-
-
1
-
-
-
-
19
1
2
-
1
4
2
1
-
-
-
-
-
-
4
4
739571
Maddock
Substitutions at the cofactor ...
Clostridium autoethanogenum
Protein Eng. Des. Sel.
28
251-258
2015
-
-
1
-
7
-
-
21
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
21
-
-
-
2
-
-
-
-
-
1
2
-
7
-
-
-
-
21
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
21
-
-
-
-
-
-
-
-
21
21
737501
Koepke
Reconstruction of an acetogeni ...
Clostridium autoethanogenum
Appl. Environ. Microbiol.
80
3394-3403
2014
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
5
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
5
-
-
-
-
-
-
-
-
5
5
738472
Cui
Utilization of excess NADH in ...
Bacillus licheniformis
J. Appl. Microbiol.
117
690-698
2014
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738637
Wang
Glycerol dehydrogenase plays a ...
Klebsiella pneumoniae, Klebsiella pneumoniae ATCC 25955
J. Biol. Chem.
289
6080-6090
2014
-
-
1
-
-
-
-
8
-
-
-
2
-
2
-
-
1
-
-
-
-
-
10
1
-
-
-
8
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
8
-
-
-
2
-
-
-
1
-
-
-
-
10
1
-
-
-
8
-
-
-
-
1
-
-
1
7
7
738878
Kochius
-
Enantioselective enzymatic syn ...
Haloarcula marismortui
J. Mol. Catal. B
103
61-66
2014
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738880
Hao
-
Biochemical characterization o ...
Bacillus subtilis, Bacillus subtilis 168
J. Mol. Catal. B
109
184-190
2014
-
-
-
-
1
-
-
-
-
-
-
4
-
72
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722559
Gao
A 2,3-butanediol dehydrogenase ...
Paenibacillus polymyxa, Paenibacillus polymyxa ZJ-9
J. Basic Microbiol.
53
733-741
2013
-
-
1
-
-
-
-
6
-
-
2
-
-
3
-
-
1
-
-
1
1
-
4
1
1
-
-
-
2
-
-
3
-
-
-
-
-
1
3
-
-
-
-
-
-
6
-
-
2
-
-
-
-
1
-
1
1
-
4
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
737366
Miao
Crystallization and preliminar ...
Bacillus coagulans, Bacillus coagulans 2-6
Acta Crystallogr. Sect. F
69
1140-1142
2013
-
-
1
1
-
-
-
-
-
1
-
2
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
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Properties of 2,3-butanediol d ...
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Bacterial 2,3-butanediol dehyd ...
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