BRENDA - Reference to 1.1.1.39; Id = 657321

Lu3+

strong inhibition, reversible slow-binding mechanism, reversible structural interconversion to the Mn2+-binding form, metal binding site structure

Homo sapiens

mitochondrion

-

Homo sapiens

5739

-

Mn2+

reversible structural interconversion to the Lu3+-binding form, metal binding site structure

Homo sapiens

-

30

-

assay at

Homo sapiens

7.4

-

assay at

Homo sapiens

NAD+

-

Homo sapiens

NADP+

-

Homo sapiens

additional information

-

additional information

inhibition kinetics

Homo sapiens

0.0048

-

Lu3+

isomerized enzyme form, pH 7.4, 30°C

Homo sapiens

0.148

-

Lu3+

native enzyme form, pH 7.4, 30°C

Homo sapiens

NAD+

-

Homo sapiens

NADP+

-

Homo sapiens

Lu3+

strong inhibition, reversible slow-binding mechanism, reversible structural interconversion to the Mn2+-binding form, metal binding site structure

Homo sapiens

additional information

-

additional information

inhibition kinetics

Homo sapiens

0.0048

-

Lu3+

isomerized enzyme form, pH 7.4, 30°C

Homo sapiens

0.148

-

Lu3+

native enzyme form, pH 7.4, 30°C

Homo sapiens

mitochondrion

-

Homo sapiens

5739

-

Mn2+

reversible structural interconversion to the Lu3+-binding form, metal binding site structure

Homo sapiens

30

-

assay at

Homo sapiens

7.4

-

assay at

Homo sapiens

738272

Niedzwiecka

NAD-preferring malic enzyme: l ...

Clupea harengus

Fish Physiol. Biochem.

43

351-360

2017

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

740471

Niedzwiecka

NAD-preferring malic enzyme: l ...

Clupea harengus

Fish Physiol. Biochem.

39

351-360

2017

1

-

1

-

2

-

1

-

2

-

1

-

2

1

-

2

-

1

-

1

-

2

-

1

-

2

-

1

-

2

-

1

-

1

-

2

1

-

2

-

1

-

1

-

1

-

741010

Hasan

Mitochondrial malic enzyme 3 i ...

Rattus norvegicus

Mol. Endocrinol.

29

396-410

2015

-

1

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

2

-

1

2

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

741121

Tronconi

Allosteric substrate inhibitio ...

Arabidopsis thaliana

Phytochemistry

111

37-47

2015

1

-

1

-

4

-

1

2

-

2

-

4

-

4

-

2

-

2

-

1

4

-

5

-

2

4

-

2

-

4

-

2

4

-

741191

Babayev

The study of NAD-malic enzyme ...

Amaranthus hybridus subsp. cruentus

Plant Physiol. Biochem.

81

84-89

2014

2

-

1

9

1

3

1

-

4

-

8

-

1

-

1

-

1

-

2

-

2

-

2

-

1

9

1

3

1

-

8

-

1

-

1

-

1

-

1

-

1

-

722082

Niedzwiecka

Purification and properties of ...

Clarias gariepinus, Clupea harengus, Cyprinus carpio, Salmo salar, Salmo trutta

Comp. Biochem. Physiol. B

164

216-220

2013

-

5

-

5

1

5

-

10

-

1

-

5

2

-

7

2

5

-

6

3

-

10

-

10

-

5

-

5

-

5

1

5

-

1

-

5

2

-

7

2

5

-

6

3

-

5

-

721353

Zhang

NAD(P)+-malic enzyme mutants o ...

Azorhizobium caulinodans, Sinorhizobium sp., Sinorhizobium sp. NGR234

Appl. Environ. Microbiol.

78

2803-2812

2012

4

-

1

-

1

-

2

6

-

5

-

12

-

1

-

1

-

5

-

1

-

1

-

4

-

4

-

1

4

-

1

-

2

-

6

-

5

-

1

-

1

-

5

-

1

-

1

-

3

-

721357

Rodriguez

Impact of malic enzymes on ant ...

Streptomyces coelicolor, Streptomyces coelicolor M145

Appl. Environ. Microbiol.

78

4571-4579

2012

-

1

-

2

-

1

-

2

-

4

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

2

-

1

-

1

-

2

-

721778

Fu

-

The effects of abiotic stresse ...

Triticum aestivum, Triticum aestivum Jinmai 47

Biol. Plant.

55

196-200

2011

-

1

-

1

-

2

-

2

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

723540

Hsieh

Determinants of nucleotide-bin ...

Ascaris suum

PLoS ONE

6

e25312

2011

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

710948

Landete

Requirement of the Lactobacill ...

Lactobacillus casei, Lactobacillus casei BL23 and ATCC 334

Appl. Environ. Microbiol.

76

84-95

2010

-

1

-

2

-

2

-

2

-

1

-

1

-

2

-

2

-

2

3

2

-

711147

Tronconi

NAD-malic enzymes of Arabidops ...

Arabidopsis thaliana

Biochem. J.

430

295-303

2010

-

1

-

1

-

7

3

1

-

2

-

4

-

1

-

3

1

-

2

1

-

1

10

-

2

-

2

-

11

10

4

2

-

2

-

2

-

3

2

-

2

-

2

4

-

711524

Sato

Isolation and properties of ma ...

Rhodopseudomonas palustris, Rhodopseudomonas palustris No. 7

Biosci. Biotechnol. Biochem.

74

75-81

2010

-

1

-

7

5

-

6

2

4

-

2

-

1

-

1

6

1

-

2

4

1

-

1

3

2

1

-

1

3

-

7

2

5

-

6

2

4

-

1

-

1

6

1

-

2

4

1

-

1

-

2

-

4

712417

Tronconi

Three different and tissue-spe ...

Arabidopsis thaliana

J. Biol. Chem.

285

11870-11879

2010

8

-

1

-

1

-

5

2

1

3

-

5

-

1

-

4

-

9

1

-

6

3

-

1

-

21

-

3

-

2

-

9

3

1

3

-

3

-

12

-

9

3

-

6

3

-

1

3

-

6

713373

Ren

Induction of erythroid differe ...

Homo sapiens

PLoS ONE

5

e12520

2010

-

1

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

712942

Pongratz

Investigating the roles of mit ...

Rattus norvegicus

Methods Enzymol.

457

425-450

2009

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

713212

Rzepka

-

Effect of abiotic stress facto ...

Mnium undulatum, Pilosella officinarum, Polytrichum commune, Polytrichum piliferum

Photosynthetica

47

141-145

2009

-

4

-

8

4

-

8

-

4

-

4

-

8

-

4

-

4

-

8

-

8

-

4

-

8

4

-

8

-

4

-

8

-

4

-

4

-

685215

Aktas

Proper positioning of the nico ...

Ascaris suum

Biochemistry

47

2539-2546

2008

-

7

-

15

1

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

2

-

7

-

15

1

-

1

-

2

-

1

-

1

-

685678

Ohno

Reverse reaction of malic enzy ...

Brevundimonas diminuta, Brevundimonas diminuta IFO 13182

Biosci. Biotechnol. Biochem.

72

1278-1282

2008

-

1

-

1

-

1

-

2

-

2

-

1

-

1

-

4

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

4

-

1

-

1

-

689604

Tronconi

Arabidopsis NAD-malic enzyme f ...

Arabidopsis thaliana

Plant Physiol.

146

1540-1552

2008

-

1

-

2

1

-

4

2

-

2

-

2

-

4

2

-

2

-

2

-

2

4

-

4

2

-

4

2

-

4

-

4

-

2

-

685123

Karsten

Multiple roles of arginine 181 ...

Ascaris suum

Biochemistry

46

14578-14588

2007

-

2

-

1

8

-

2

-

1

-

1

-

2

-

1

-

1

-

3

2

-

3

-

2

-

1

2

8

-

2

-

1

-

2

-

1

-

1

-

685622

Chang

Metal ions stabilize a dimeric ...

Homo sapiens

Biophys. J.

93

3977-3988

2007

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

687568

Pongratz

Cytosolic and mitochondrial ma ...

Rattus norvegicus

J. Biol. Chem.

282

200-207

2007

-

1

-

1

-

1

-

1

-

2

-

3

1

-

2

-

2

-

1

2

-

1

-

1

-

1

-

3

1

-

2

-

669132

Mitsch

Malic Enzyme Cofactor and Doma ...

Sinorhizobium meliloti

J. Bacteriol.

189

160-168

2006

-

1

-

1

-

1

-

1

-

2

-

2

-

2

-

1

-

1

-

1

-

2

-

656983

Lara

Induction of a crassulacean ac ...

Portulaca oleracea

Plant Cell Physiol.

45

618-626

2004

-

1

-

3

1

-

1

-

1

-

2

3

-

2

-

1

-

1

-

1

-

1

-

1

-

3

1

-

1

-

2

3

-

2

-

1

-

1

-

657321

Kuo

Metal-induced reversible struc ...

Homo sapiens

Proteins

54

404-411

2004

-

1

-

1

-

1

-

1

-

1

-

2

3

-

2

-

1

3

-

1

-

1

-

1

-

654720

Karsten

Ascaris suum NAD-malic enzyme ...

Ascaris suum

Biochemistry

42

9712-9721

2003

2

-

1

-

2

-

1

3

-

1

-

1

-

1

-

1

-

1

-

2

1

-

2

-

1

2

-

2

-

1

3

-

1

-

1

-

1

-

1

-

656163

Rao

Crystallographic studies on As ...

Ascaris suum

J. Biol. Chem.

278

38051-38058

2003

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

2

1

-

1

-

1

-

1

-

657362

Tao

Crystal structures of substrat ...

Homo sapiens

Structure

11

1141-1150

2003

1

-

1

-

1

-

1

-

1

-

1

-

1

-

4

-

1

-

4

1

-

1

-

1

-

1

-

654623

Liu

Alternative substrates for mal ...

Ascaris suum

Biochemistry

41

12200-12203

2002

-

1

6

-

1

-

1

-

1

-

6

-

1

-

1

-

1

3

-

1

-

1

3

6

-

1

-

6

-

1

-

1

-

654651

Coleman

Crystal structure of the malic ...

Ascaris suum

Biochemistry

41

6928-6938

2002

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286706

Voegele

Characterization of two member ...

Sinorhizobium meliloti

Biochim. Biophys. Acta

1432

275-285

1999

6

-

11

2

-

1

-

2

-

1

-

1

2

1

-

2

-

6

-

2

-

11

-

2

-

1

-

1

-

1

2

1

-

286720

Chen

Purification and characterizat ...

Bradyrhizobium japonicum

Appl. Environ. Microbiol.

64

4073-4075

1998

10

-

11

-

2

-

1

-

1

-

1

-

1

-

1

-

10

-

1

-

11

-

2

-

1

-

1

-

1

-

286719

Farias de Aragao

-

Purification and partial chara ...

Vigna unguiculata

Plant Physiol. Biochem.

34

363-368

1996

-

1

-

1

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

3

-

1

-

1

-

1

-

1

-

286717

Hrdy

Purification and partial chara ...

Tritrichomonas suis

Parasitology

107

379-385

1993

-

4

2

1

-

2

-

1

-

1

-

2

-

2

-

2

-

4

2

1

-

1

-

1

-

2

-

286718

Suye

-

Purification and properties of ...

Brevundimonas diminuta

J. Ferment. Bioeng.

73

343-347

1992

-

7

2

-

2

-

1

-

1

-

2

-

2

1

2

-

1

2

-

2

-

7

-

2

-

2

-

1

-

2

-

2

1

2

-

1

-

286701

Willeford

pH Effects on the activity and ...

Solanum tuberosum

Plant Physiol.

84

1084-1087

1987

-

1

-

1

-

1

-

1

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

1

-

286702

Willeford

Evidence for a multiple subuni ...

Crassula argentea, Solanum tuberosum

J. Biol. Chem.

262

8423-8429

1987

-

2

-

6

-

1

-

1

-

2

1

-

2

-

2

-

2

-

1

-

1

-

2

1

-

286703

Willeford

Regulation of the NAD malic en ...

Crassula argentea

Plant Physiol.

80

792-795

1986

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286700

Artus

-

NAD-malic enzyme from plants ...

Atriplex spongiosa, Brassica oleracea, Crassula argentea, Solanum tuberosum

FEBS Lett.

182

225-233

1985

-

7

-

4

-

3

-

4

-

4

-

4

-

7

-

3

-

4

-

286704

Day

Activation of NAD-linked malic ...

Brassica oleracea, Solanum tuberosum

Arch. Biochem. Biophys.

231

233-242

1984

2

-

2

-

2

-

2

-

2

-

2

-

4

-

2

-

2

-

2

-

2

-

2

-

2

-

2

-

4

-

286705

Canellas

Kinetic properties of NAD mali ...

Brassica oleracea

Arch. Biochem. Biophys.

229

414-425

1984

-

2

3

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

3

-

3

-

1

-

1

-

1

-

286707

Wedding

Physical and kinetic propertie ...

Crassula argentea

Plant Physiol.

72

1021-1028

1983

6

-

5

7

-

2

4

-

1

-

1

-

1

-

3

-

2

-

6

-

2

-

5

-

7

-

2

4

-

1

-

1

-

3

-

286708

Hatch

Determination of NAD malic enz ...

Amaranthus retroflexus

Plant Physiol.

69

483-491

1982

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286709

Wedding

Slow transients in the activit ...

Crassula argentea

Plant Physiol.

68

1416-1423

1981

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

2

-

286710

Grover

Purification of NAD malic enzy ...

Solanum tuberosum

Arch. Biochem. Biophys.

209

396-407

1981

-

8

-

2

3

-

1

-

1

-

1

-

2

1

-

1

3

-

2

-

2

-

8

-

2

3

-

1

-

1

-

2

1

-

1

3

-

286711

Canellas

Substrate and metal ion intera ...

Brassica oleracea

Arch. Biochem. Biophys.

199

259-264

1980

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

286712

Hoek

Nicotinamide-adenine dinucleot ...

Apis mellifera, Glossina austeni, Glossina longipennis, Glossina morsitans, Glossina pallidipes, Heliocarpus sp., Odontotermes sp., Periplaneta americana, Sarcophaga sp., Schistocerca gregaria, Spodoptera exempta

Biochem. J.

160

253-262

1976

-

2

-

11

-

1

-

12

-

1

-

12

-

12

-

2

-

1

-

12

-

1

-

286713

Hatch

Properties of leaf NAD malic e ...

Amaranthus edulis, Atriplex spongiosa, Panicum miliaceum

Arch. Biochem. Biophys.

165

188-200

1974

4

-

1

4

1

-

6

1

-

3

-

1

-

3

-

1

4

-

2

-

4

-

4

-

4

-

1

-

4

-

1

-

6

1

-

1

-

3

-

1

4

-

2

-

286714

Mounib

NAD- and NADP-malic enzymes in ...

Bos taurus, Gadidae, Homo sapiens, salmon

FEBS Lett.

48

79-84

1974

-

4

-

4

-

4

-

4

-

4

-

4

-

4

-

286715

Lin

Malic enzymes of rabbit heart ...

Oryctolagus cuniculus

J. Biol. Chem.

249

3867-3875

1974

-

2

8

1

2

1

-

1

-

1

-

1

-

3

-

1

-

2

-

2

-

2

-

8

1

2

1

-

1

-

1

-

3

-

1

-

286716

Eyzaguirre

Two malic enzymes in Pseudomon ...

Pseudomonas aeruginosa

J. Bacteriol.

116

215-221

1973

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

2

-

Metal-induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme

Data extracted from this reference: