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Literature summary for 1.1.1.39 extracted from
- Nicotinamide-adenine dinucleotide-linked malic enzyme in flight muscle of the tse-tse fly (Glossina) and other insects (1976), Biochem. J., 160, 253-262.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.21 | - |
NAD+ | - |
Glossina morsitans |  |
| 2.5 | - |
(S)-malate | - |
Glossina morsitans | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | 30% of the activity | Glossina morsitans | 5829 | - |
| mitochondrion | 65% of the activity | Glossina morsitans | 5739 | - |
| mitochondrion | predominantly in the matrix space | Glossina morsitans | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | completely dependent on the presence of Mg2+ or Mn2+ | Glossina morsitans | |
| Mn2+ | completely dependent on the presence of Mg2+ or Mn2+ | Glossina morsitans | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Apis mellifera | - |
- |
- |
| Glossina austeni | - |
- |
- |
| Glossina longipennis | - |
- |
- |
| Glossina morsitans | - |
- |
- |
| Glossina pallidipes | - |
- |
- |
| Heliocarpus sp. | - |
- |
- |
| Odontotermes sp. | - |
- |
- |
| Periplaneta americana | - |
- |
- |
| Sarcophaga sp. | - |
- |
- |
| Schistocerca gregaria | - |
- |
- |
| Spodoptera exempta | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| flight muscle | - |
Glossina morsitans | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 24 | - |
- |
Glossina morsitans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NADP+ | at 1.5% of the activity with NAD+ | Glossina morsitans | pyruvate + CO2 + NADPH | - |
? | |
| malate + NAD+ | - |
Schistocerca gregaria | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Apis mellifera | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Glossina longipennis | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Glossina morsitans | pyruvate + CO2 + NADH + H+ | - |
ir | |
| malate + NAD+ | - |
Glossina austeni | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Glossina pallidipes | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Sarcophaga sp. | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Periplaneta americana | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Odontotermes sp. | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Spodoptera exempta | pyruvate + CO2 + NADH + H+ | - |
? | |
| malate + NAD+ | - |
Heliocarpus sp. | pyruvate + CO2 + NADH + H+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | 7.9 | - |
Glossina morsitans |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8.7 | pH 7.0: about 30% of maximal activity, pH 8.7: about 45% of maximal activity | Glossina morsitans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | cofactor | Schistocerca gregaria | |
| NAD+ | cofactor | Apis mellifera | |
| NAD+ | cofactor | Glossina longipennis | |
| NAD+ | cofactor | Glossina morsitans | |
| NAD+ | cofactor | Glossina austeni | |
| NAD+ | cofactor | Glossina pallidipes | |
| NAD+ | cofactor | Sarcophaga sp. | |
| NAD+ | cofactor | Periplaneta americana | |
| NAD+ | cofactor | Odontotermes sp. | |
| NAD+ | cofactor | Spodoptera exempta | |
| NAD+ | cofactor | Heliocarpus sp. | |
| NADP+ | at 1.5% of the activity with NAD+ | Glossina morsitans | |
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