BRENDA - Enzyme Database show
show all sequences of 1.1.1.39

Activation of NAD-linked malic enzyme in intact plant mitochondria by exogenous coenzyme A

Day, D.A.; Neuburger, M.; Douce, R.; Arch. Biochem. Biophys. 231, 233-242 (1984)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
coenzyme A
serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity
Brassica oleracea
coenzyme A
serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity
Solanum tuberosum
Inhibitors
Inhibitors
Commentary
Organism
Structure
oxaloacetate
-
Brassica oleracea
oxaloacetate
-
Solanum tuberosum
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Brassica oleracea
5739
-
mitochondrion
-
Solanum tuberosum
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(S)-malate + NAD+
Solanum tuberosum
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
?
-
-
?
(S)-malate + NAD+
Brassica oleracea
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
?
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Brassica oleracea
-
-
-
Solanum tuberosum
-
var. urgenta
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
bud
-
Brassica oleracea
-
bud
-
Solanum tuberosum
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(S)-malate + NAD+
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
286704
Solanum tuberosum
?
-
-
-
?
(S)-malate + NAD+
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
286704
Brassica oleracea
?
-
-
-
?
malate + NAD+
-
286704
Solanum tuberosum
pyruvate + CO2 + NADH
-
286704
Solanum tuberosum
?
malate + NAD+
-
286704
Brassica oleracea
pyruvate + CO2 + NADH
-
286704
Brassica oleracea
?
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
cofactor
Solanum tuberosum
NAD+
cofactor
Brassica oleracea
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
coenzyme A
serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity
Brassica oleracea
coenzyme A
serves to broaden the pH-optimum, at pH 7.5 approximately 4fold stimulation, the effect is more marked when HCO3 is also present, below pH 7 no effect on activity
Solanum tuberosum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
cofactor
Solanum tuberosum
NAD+
cofactor
Brassica oleracea
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
oxaloacetate
-
Brassica oleracea
oxaloacetate
-
Solanum tuberosum
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Brassica oleracea
5739
-
mitochondrion
-
Solanum tuberosum
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(S)-malate + NAD+
Solanum tuberosum
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
?
-
-
?
(S)-malate + NAD+
Brassica oleracea
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
bud
-
Brassica oleracea
-
bud
-
Solanum tuberosum
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(S)-malate + NAD+
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
286704
Solanum tuberosum
?
-
-
-
?
(S)-malate + NAD+
the enzyme plays a special role in the decarboxylation of C4 acids to pyruvate and CO2, which are used in subsequent photosynthesis. pH, NAD+, and coenzyme A levels in the matrix act together to regulate (S)-malate oxidation
286704
Brassica oleracea
?
-
-
-
?
malate + NAD+
-
286704
Solanum tuberosum
pyruvate + CO2 + NADH
-
286704
Solanum tuberosum
?
malate + NAD+
-
286704
Brassica oleracea
pyruvate + CO2 + NADH
-
286704
Brassica oleracea
?
Other publictions for EC 1.1.1.39
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738272
Niedzwiecka
NAD-preferring malic enzyme: l ...
Clupea harengus
Fish Physiol. Biochem.
43
351-360
2017
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1
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1
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1
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1
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1
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722082
Niedzwiecka
Purification and properties of ...
Clupea harengus
Comp. Biochem. Physiol. B
164
216-220
2013
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5
-
1
1
1
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6
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1
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1
2
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2
1
1
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2
2
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2
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2
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5
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1
1
1
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1
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1
2
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2
1
1
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-
2
2
-
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-
721353
Zhang
NAD(P)+-malic enzyme mutants o ...
Azorhizobium caulinodans, Sinorhizobium sp., Sinorhizobium sp. NGR234
Appl. Environ. Microbiol.
78
2803-2812
2012
4
-
1
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1
-
2
6
-
-
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5
-
13
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1
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1
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5
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1
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1
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4
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4
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1
4
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1
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2
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6
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5
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1
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1
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5
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1
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1
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3
3
-
-
-
721357
Rodriguez
Impact of malic enzymes on ant ...
Streptomyces coelicolor, Streptomyces coelicolor M145
Appl. Environ. Microbiol.
78
4571-4579
2012
-
-
1
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-
-
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2
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1
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2
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4
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1
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1
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1
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1
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2
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1
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2
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1
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1
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2
2
-
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-
721778
Fu
-
The effects of abiotic stresse ...
Triticum aestivum, Triticum aestivum Jinmai 47
Biol. Plant.
55
196-200
2011
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1
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1
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2
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2
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1
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1
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1
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2
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1
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1
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1
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723540
Hsieh
Determinants of nucleotide-bin ...
Ascaris suum
PLoS ONE
6
e25312
2011
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1
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1
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3
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1
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710948
Landete
Requirement of the Lactobacill ...
Lactobacillus casei, Lactobacillus casei BL23 and ATCC 334
Appl. Environ. Microbiol.
76
84-95
2010
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1
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2
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2
3
3
2
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711147
Tronconi
NAD-malic enzymes of Arabidops ...
Arabidopsis thaliana
Biochem. J.
430
295-303
2010
-
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1
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1
-
7
3
1
1
-
2
-
4
-
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1
1
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3
1
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2
1
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1
10
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2
2
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2
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11
10
4
2
2
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2
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2
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3
2
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2
2
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2
4
-
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711524
Sato
Isolation and properties of ma ...
Rhodopseudomonas palustris, Rhodopseudomonas palustris No. 7
Biosci. Biotechnol. Biochem.
74
75-81
2010
-
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1
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7
5
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6
2
4
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2
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1
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1
1
6
1
1
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2
4
1
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3
2
1
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1
3
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7
2
5
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6
2
4
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1
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1
1
6
1
1
-
2
4
1
-
1
1
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2
2
-
4
4
712417
Tronconi
Three different and tissue-spe ...
Arabidopsis thaliana
J. Biol. Chem.
285
11870-11879
2010
8
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1
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1
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5
2
1
1
3
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5
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1
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4
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9
1
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6
3
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1
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21
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3
3
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2
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9
3
3
1
3
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3
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12
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9
3
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6
3
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1
3
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6
6
713373
Ren
Induction of erythroid differe ...
Homo sapiens
PLoS ONE
5
e12520
2010
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1
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1
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712942
Pongratz
Investigating the roles of mit ...
Rattus norvegicus
Methods Enzymol.
457
425-450
2009
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1
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1
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1
1
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1
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1
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2
2
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713212
Rzepka
-
Effect of abiotic stress facto ...
Mnium undulatum, Pilosella officinarum, Polytrichum commune, Polytrichum piliferum
Photosynthetica
47
141-145
2009
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4
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8
4
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8
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4
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4
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8
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4
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685215
Aktas
Proper positioning of the nico ...
Ascaris suum
Biochemistry
47
2539-2546
2008
-
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7
-
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15
1
1
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1
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1
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1
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7
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15
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685678
Ohno
Reverse reaction of malic enzy ...
Brevundimonas diminuta, Brevundimonas diminuta IFO 13182
Biosci. Biotechnol. Biochem.
72
1278-1282
2008
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1
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1
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689604
Tronconi
Arabidopsis NAD-malic enzyme f ...
Arabidopsis thaliana
Plant Physiol.
146
1540-1552
2008
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1
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2
1
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4
2
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2
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2
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4
4
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2
2
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685123
Karsten
Multiple roles of arginine 181 ...
Ascaris suum
Biochemistry
46
14578-14588
2007
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2
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1
8
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2
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2
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1
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1
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685622
Chang
Metal ions stabilize a dimeric ...
Homo sapiens
Biophys. J.
93
3977-3988
2007
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1
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1
1
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1
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1
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1
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1
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687568
Pongratz
Cytosolic and mitochondrial ma ...
Rattus norvegicus
J. Biol. Chem.
282
200-207
2007
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1
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1
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1
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669132
Mitsch
Malic Enzyme Cofactor and Doma ...
Sinorhizobium meliloti
J. Bacteriol.
189
160-168
2006
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1
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1
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1
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2
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1
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657321
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Metal-induced reversible struc ...
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654720
Karsten
Ascaris suum NAD-malic enzyme ...
Ascaris suum
Biochemistry
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2003
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656163
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Crystallographic studies on As ...
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Tao
Crystal structures of substrat ...
Homo sapiens
Structure
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654623
Liu
Alternative substrates for mal ...
Ascaris suum
Biochemistry
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2002
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654651
Coleman
Crystal structure of the malic ...
Ascaris suum
Biochemistry
41
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2002
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286706
Voegele
Characterization of two member ...
Sinorhizobium meliloti
Biochim. Biophys. Acta
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1999
6
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11
2
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1
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2
1
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286720
Chen
Purification and characterizat ...
Bradyrhizobium japonicum
Appl. Environ. Microbiol.
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10
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2
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10
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286719
Farias de Aragao
-
Purification and partial chara ...
Vigna unguiculata
Plant Physiol. Biochem.
34
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1996
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1
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1
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1
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286717
Hrdy
Purification and partial chara ...
Tritrichomonas suis
Parasitology
107
379-385
1993
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4
2
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286718
Suye
-
Purification and properties of ...
Brevundimonas diminuta
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1
1
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2
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1
1
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286701
Willeford
pH Effects on the activity and ...
Solanum tuberosum
Plant Physiol.
84
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1987
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1
1
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286702
Willeford
Evidence for a multiple subuni ...
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286703
Willeford
Regulation of the NAD malic en ...
Crassula argentea
Plant Physiol.
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286700
Artus
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NAD-malic enzyme from plants ...
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FEBS Lett.
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1985
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Day
Activation of NAD-linked malic ...
Brassica oleracea, Solanum tuberosum
Arch. Biochem. Biophys.
231
233-242
1984
2
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4
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286705
Canellas
Kinetic properties of NAD mali ...
Brassica oleracea
Arch. Biochem. Biophys.
229
414-425
1984
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1
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286707
Wedding
Physical and kinetic propertie ...
Crassula argentea
Plant Physiol.
72
1021-1028
1983
6
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7
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2
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6
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1
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286708
Hatch
Determination of NAD malic enz ...
Amaranthus retroflexus
Plant Physiol.
69
483-491
1982
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1
1
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286709
Wedding
Slow transients in the activit ...
Crassula argentea
Plant Physiol.
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1981
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2
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1
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1
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-
-
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2
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286710
Grover
Purification of NAD malic enzy ...
Solanum tuberosum
Arch. Biochem. Biophys.
209
396-407
1981
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8
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3
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1
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1
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1
3
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2
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2
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8
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2
3
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1
-
1
1
-
2
1
-
-
-
1
3
-
-
-
-
-
-
-
-
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286711
Canellas
Substrate and metal ion intera ...
Brassica oleracea
Arch. Biochem. Biophys.
199
259-264
1980
-
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-
-
-
-
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1
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1
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1
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2
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1
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1
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1
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-
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2
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-
-
-
-
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286712
Hoek
Nicotinamide-adenine dinucleot ...
Apis mellifera, Glossina austeni, Glossina longipennis, Glossina morsitans, Glossina pallidipes, Heliocarpus sp., Odontotermes sp., Periplaneta americana, Sarcophaga sp., Schistocerca gregaria, Spodoptera exempta
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1
1
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12
-
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1
1
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12
-
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12
-
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2
2
2
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-
-
-
-
1
1
-
12
-
-
-
-
-
1
1
-
-
-
-
-
-
-
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286713
Hatch
Properties of leaf NAD malic e ...
Amaranthus edulis, Atriplex spongiosa, Panicum miliaceum
Arch. Biochem. Biophys.
165
188-200
1974
4
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1
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3
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1
4
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2
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4
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4
-
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4
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1
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4
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1
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6
1
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1
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3
-
1
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
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286714
Mounib
NAD- and NADP-malic enzymes in ...
Bos taurus, Gadidae, Homo sapiens, salmon
FEBS Lett.
48
79-84
1974
-
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4
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4
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4
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4
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4
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4
-
-
-
-
-
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286715
Lin
Malic enzymes of rabbit heart ...
Oryctolagus cuniculus
J. Biol. Chem.
249
3867-3875
1974
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2
8
1
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1
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3
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1
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2
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2
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2
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8
1
2
1
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1
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1
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3
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1
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286716
Eyzaguirre
Two malic enzymes in Pseudomon ...
Pseudomonas aeruginosa
J. Bacteriol.
116
215-221
1973
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1
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1
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2
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2
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