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Literature summary for 1.1.1.37 extracted from
- Function, kinetic properties, crystallization, and regulation of microbial malate dehydrogenase (2016), J. Zhejiang Univ. Sci. B, 17, 247-261.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| L-malate | at over 00.18 mM | Pseudomonas stutzeri |  |
| NaCl | activates at 3 M | Haloarcula marismortui | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene mdh | Haloarcula marismortui |
| gene mdh | Bacillus subtilis |
| gene mdh | Methanothermobacter thermautotrophicus |
| gene mdh | Pseudomonas stutzeri |
| gene mdh | Nitrosomonas europaea |
| gene mdh | Corynebacterium glutamicum |
| gene mdh | Streptomyces coelicolor |
| gene mdh | Helicobacter pylori |
| gene mdh | Kitasatospora aureofaciens |
| gene mdh | Methanocaldococcus jannaschii |
| gene mdh | Archaeoglobus fulgidus |
| gene mdh | uncultured bacterium |
| gene mdh | Glaesserella parasuis |
| gene mdh | Aeropyrum pernix |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure determination and analysis | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (S)-malate | at 1 mM | Methanothermobacter thermautotrophicus | |
| 2-oxoglutarate | - |
Pseudomonas stutzeri | |
| ADP | - |
Pseudomonas stutzeri | |
| Ag+ | - |
Pseudomonas stutzeri | |
| Citric acid | - |
Pseudomonas stutzeri | |
| Cu2+ | - |
Pseudomonas stutzeri | |
| Fe2+ | - |
Streptomyces coelicolor | |
| L-malate | MDH activity is strongly inhibited by excess of L-malate | Streptomyces coelicolor | |
| NAD+ | MDH activity is inhibited by 0.5 mM NADH | Methanothermobacter thermautotrophicus | |
| NAD+ | - |
Pseudomonas stutzeri | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Aeropyrum pernix | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH, over 2 mM | Archaeoglobus fulgidus | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Bacillus subtilis | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH over 1 mM | Corynebacterium glutamicum | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Escherichia coli | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Glaesserella parasuis | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Haloarcula marismortui | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Helicobacter pylori | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Kitasatospora aureofaciens | |
| NADH | MDH activity is inhibited by over 200 mM NADH | Methanothermobacter thermautotrophicus | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Nitrosomonas europaea | |
| NADH | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | uncultured bacterium | |
| oxalic acid | inhibits L-malate oxidation reaction | Pseudomonas stutzeri | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Aeropyrum pernix | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH, overv 2 mM | Archaeoglobus fulgidus | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Bacillus subtilis | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH over 1 mM | Corynebacterium glutamicum | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Escherichia coli | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Glaesserella parasuis | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Haloarcula marismortui | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Helicobacter pylori | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Kitasatospora aureofaciens | |
| oxaloacetate | - |
Methanothermobacter thermautotrophicus | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate and NADH | Nitrosomonas europaea | |
| oxaloacetate | MDH activity is inhibited at 0.33 mM | Pseudomonas stutzeri | |
| oxaloacetate | MDH activity is strongly inhibited by excess of oxaloacetate | Streptomyces coelicolor | |
| oxaloacetate | MDH activity is inhibited by over 250 mM oxaloacetate | uncultured bacterium | |
| Zn2+ | - |
Streptomyces coelicolor | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics | Haloarcula marismortui | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Bacillus subtilis | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Escherichia coli | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Methanothermobacter thermautotrophicus | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Pseudomonas stutzeri | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Nitrosomonas europaea | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Corynebacterium glutamicum | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Streptomyces coelicolor | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Helicobacter pylori | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Kitasatospora aureofaciens | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Archaeoglobus fulgidus | |
| additional information | - |
additional information | Michaelis-Menten kinetics | uncultured bacterium | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Glaesserella parasuis | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Aeropyrum pernix | |
| 0.0001 | - |
oxaloacetate | pH and temperature not specified in the publication with NAD+ | Kitasatospora aureofaciens | |
| 0.00012 | - |
(S)-malate | pH and temperature not specified in the publication | Escherichia coli | |
| 0.00087 | - |
NAD+ | pH and temperature not specified in the publication | Escherichia coli | |
| 0.014 | - |
NADH | pH and temperature not specified in the publication | Bacillus subtilis | |
| 0.0165 | - |
NADH | pH and temperature not specified in the publication | Glaesserella parasuis | |
| 0.0189 | - |
oxaloacetate | pH and temperature not specified in the publication | Streptomyces coelicolor | |
| 0.02 | - |
oxaloacetate | pH and temperature not specified in the publication | Nitrosomonas europaea | |
| 0.022 | - |
NADH | pH and temperature not specified in the publication | Nitrosomonas europaea | |
| 0.022 | - |
oxaloacetate | pH and temperature not specified in the publication | Bacillus subtilis | |
| 0.024 | - |
NAD+ | pH and temperature not specified in the publication | Nitrosomonas europaea | |
| 0.024 | - |
NADH | pH and temperature not specified in the publication | Archaeoglobus fulgidus | |
| 0.03 | - |
NADH | pH and temperature not specified in the publication | uncultured bacterium | |
| 0.03 | - |
oxaloacetate | pH and temperature not specified in the publication | Methanothermobacter thermautotrophicus | |
| 0.032 | - |
oxaloacetate | pH and temperature not specified in the publication | Pseudomonas stutzeri | |
| 0.036 | - |
NADH | pH and temperature not specified in the publication | Pseudomonas stutzeri | |
| 0.043 | - |
oxaloacetate | pH and temperature not specified in the publication | Archaeoglobus fulgidus | |
| 0.05 | - |
oxaloacetate | pH and temperature not specified in the publication | uncultured bacterium | |
| 0.063 | - |
(S)-malate | at 0.08-0.18 mM, pH and temperature not specified in the publication | Pseudomonas stutzeri | |
| 0.065 | - |
NADH | pH and temperature not specified in the publication | Helicobacter pylori | |
| 0.072 | - |
oxaloacetate | pH and temperature not specified in the publication | Glaesserella parasuis | |
| 0.083 | - |
NADH | pH and temperature not specified in the publication | Streptomyces coelicolor | |
| 0.085 | - |
NADH | pH and temperature not specified in the publication | Kitasatospora aureofaciens | |
| 0.09 | - |
NAD+ | pH and temperature not specified in the publication | Methanothermobacter thermautotrophicus | |
| 0.09 | - |
NADH | pH and temperature not specified in the publication | Methanothermobacter thermautotrophicus | |
| 0.1 | - |
NAD+ | pH and temperature not specified in the publication | Bacillus subtilis | |
| 0.117 | - |
NAD+ | pH and temperature not specified in the publication | Glaesserella parasuis | |
| 0.12 | - |
(S)-malate | pH and temperature not specified in the publication | Aeropyrum pernix | |
| 0.128 | - |
oxaloacetate | pH and temperature not specified in the publication | Helicobacter pylori | |
| 0.15 | - |
NAD+ | pH and temperature not specified in the publication | Streptomyces coelicolor | |
| 0.161 | - |
NAD+ | pH and temperature not specified in the publication | Helicobacter pylori | |
| 0.177 | - |
(S)-malate | pH and temperature not specified in the publication | Helicobacter pylori | |
| 0.26 | - |
(S)-malate | pH and temperature not specified in the publication | Bacillus subtilis | |
| 0.27 | - |
NAD+ | pH and temperature not specified in the publication | Kitasatospora aureofaciens | |
| 0.34 | - |
NAD+ | pH and temperature not specified in the publication | Pseudomonas stutzeri | |
| 0.4 | - |
(S)-malate | pH and temperature not specified in the publication | Methanothermobacter thermautotrophicus | |
| 0.49 | - |
(S)-malate | pH and temperature not specified in the publication | Streptomyces coelicolor | |
| 0.55 | - |
(S)-malate | pH and temperature not specified in the publication | Glaesserella parasuis | |
| 0.67 | - |
(S)-malate | at 0.18-10.0 mM, pH and temperature not specified in the publication | Pseudomonas stutzeri | |
| 0.87 | - |
NAD+ | pH and temperature not specified in the publication | Aeropyrum pernix | |
| 1.1 | - |
NAD+ | pH and temperature not specified in the publication | uncultured bacterium | |
| 4 | - |
(S)-malate | pH and temperature not specified in the publication | uncultured bacterium | |
| 5 | - |
(S)-malate | pH and temperature not specified in the publication | Nitrosomonas europaea | |
| 9 | - |
(S)-malate | pH and temperature not specified in the publication | Kitasatospora aureofaciens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NAD+ | Haloarcula marismortui | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Bacillus subtilis | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Escherichia coli | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Methanothermobacter thermautotrophicus | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Pseudomonas stutzeri | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Nitrosomonas europaea | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Corynebacterium glutamicum | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Streptomyces coelicolor | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Helicobacter pylori | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Kitasatospora aureofaciens | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Methanocaldococcus jannaschii | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Archaeoglobus fulgidus | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | uncultured bacterium | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Glaesserella parasuis | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Aeropyrum pernix | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | uncultured bacterium MPOB | - |
oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | Bacillus subtilis B1 | - |
oxaloacetate + NADH + H+ | - |
r | |
| oxaloacetate + NADH + H+ | Haloarcula marismortui | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Bacillus subtilis | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Escherichia coli | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Methanothermobacter thermautotrophicus | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Pseudomonas stutzeri | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Nitrosomonas europaea | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Corynebacterium glutamicum | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Streptomyces coelicolor | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Helicobacter pylori | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Kitasatospora aureofaciens | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Methanocaldococcus jannaschii | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Archaeoglobus fulgidus | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | uncultured bacterium | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Glaesserella parasuis | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Aeropyrum pernix | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | uncultured bacterium MPOB | - |
(S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | Bacillus subtilis B1 | - |
(S)-malate + NAD+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aeropyrum pernix | - |
- |
- |
| Archaeoglobus fulgidus | - |
- |
- |
| Bacillus subtilis | - |
- |
- |
| Bacillus subtilis B1 | - |
- |
- |
| Corynebacterium glutamicum | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Glaesserella parasuis | - |
- |
- |
| Haloarcula marismortui | - |
- |
- |
| Helicobacter pylori | - |
- |
- |
| Kitasatospora aureofaciens | - |
- |
- |
| Methanocaldococcus jannaschii | - |
- |
- |
| Methanothermobacter thermautotrophicus | - |
- |
- |
| Nitrosomonas europaea | - |
- |
- |
| Pseudomonas stutzeri | - |
- |
- |
| Streptomyces coelicolor | - |
- |
- |
| uncultured bacterium | - |
a syntropic propionate-oxidizing strain | - |
| uncultured bacterium MPOB | - |
a syntropic propionate-oxidizing strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | increased enzyme content in cells grown on acid media | Escherichia coli | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NAD+ | - |
Haloarcula marismortui | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Bacillus subtilis | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Escherichia coli | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Methanothermobacter thermautotrophicus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Pseudomonas stutzeri | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Nitrosomonas europaea | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Corynebacterium glutamicum | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Streptomyces coelicolor | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Helicobacter pylori | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Kitasatospora aureofaciens | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Methanocaldococcus jannaschii | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Archaeoglobus fulgidus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
uncultured bacterium | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Glaesserella parasuis | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Aeropyrum pernix | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
uncultured bacterium MPOB | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Bacillus subtilis B1 | oxaloacetate + NADH + H+ | - |
r | |
| additional information | the dual specificity for the cofactor results from alanine at position 53 in Methanobacterium jannaschii | Methanocaldococcus jannaschii | ? | - |
? | |
| oxaloacetate + NADH + H+ | - |
Haloarcula marismortui | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Bacillus subtilis | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Escherichia coli | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Methanothermobacter thermautotrophicus | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Pseudomonas stutzeri | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Nitrosomonas europaea | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Corynebacterium glutamicum | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Streptomyces coelicolor | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Helicobacter pylori | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Kitasatospora aureofaciens | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Methanocaldococcus jannaschii | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Archaeoglobus fulgidus | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
uncultured bacterium | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Glaesserella parasuis | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Aeropyrum pernix | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
uncultured bacterium MPOB | (S)-malate + NAD+ | - |
r | |
| oxaloacetate + NADH + H+ | - |
Bacillus subtilis B1 | (S)-malate + NAD+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | oligomeric states of MDHs, overview | Haloarcula marismortui |
| More | oligomeric states of MDHs, overview | Bacillus subtilis |
| More | oligomeric states of MDHs, overview | Methanothermobacter thermautotrophicus |
| More | oligomeric states of MDHs, overview | Pseudomonas stutzeri |
| More | oligomeric states of MDHs, overview | Nitrosomonas europaea |
| More | oligomeric states of MDHs, overview | Corynebacterium glutamicum |
| More | oligomeric states of MDHs, overview | Streptomyces coelicolor |
| More | oligomeric states of MDHs, overview | Helicobacter pylori |
| More | oligomeric states of MDHs, overview | Kitasatospora aureofaciens |
| More | oligomeric states of MDHs, overview | Archaeoglobus fulgidus |
| More | oligomeric states of MDHs, overview | uncultured bacterium |
| More | oligomeric states of MDHs, overview | Glaesserella parasuis |
| More | oligomeric states of MDHs, overview | Aeropyrum pernix |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L-malate:NAD oxidoreductase | - |
Haloarcula marismortui |
| L-malate:NAD oxidoreductase | - |
Bacillus subtilis |
| L-malate:NAD oxidoreductase | - |
Escherichia coli |
| L-malate:NAD oxidoreductase | - |
Methanothermobacter thermautotrophicus |
| L-malate:NAD oxidoreductase | - |
Pseudomonas stutzeri |
| L-malate:NAD oxidoreductase | - |
Nitrosomonas europaea |
| L-malate:NAD oxidoreductase | - |
Corynebacterium glutamicum |
| L-malate:NAD oxidoreductase | - |
Streptomyces coelicolor |
| L-malate:NAD oxidoreductase | - |
Helicobacter pylori |
| L-malate:NAD oxidoreductase | - |
Kitasatospora aureofaciens |
| L-malate:NAD oxidoreductase | - |
Methanocaldococcus jannaschii |
| L-malate:NAD oxidoreductase | - |
Archaeoglobus fulgidus |
| L-malate:NAD oxidoreductase | - |
uncultured bacterium |
| L-malate:NAD oxidoreductase | - |
Glaesserella parasuis |
| L-malate:NAD oxidoreductase | - |
Aeropyrum pernix |
| MDH | - |
Haloarcula marismortui |
| MDH | - |
Bacillus subtilis |
| MDH | - |
Escherichia coli |
| MDH | - |
Methanothermobacter thermautotrophicus |
| MDH | - |
Pseudomonas stutzeri |
| MDH | - |
Nitrosomonas europaea |
| MDH | - |
Corynebacterium glutamicum |
| MDH | - |
Streptomyces coelicolor |
| MDH | - |
Helicobacter pylori |
| MDH | - |
Kitasatospora aureofaciens |
| MDH | - |
Methanocaldococcus jannaschii |
| MDH | - |
Archaeoglobus fulgidus |
| MDH | - |
uncultured bacterium |
| MDH | - |
Glaesserella parasuis |
| MDH | - |
Aeropyrum pernix |
| NAD+-dependent malate dehydrogenase | - |
Haloarcula marismortui |
| NAD+-dependent malate dehydrogenase | - |
Bacillus subtilis |
| NAD+-dependent malate dehydrogenase | - |
Escherichia coli |
| NAD+-dependent malate dehydrogenase | - |
Methanothermobacter thermautotrophicus |
| NAD+-dependent malate dehydrogenase | - |
Pseudomonas stutzeri |
| NAD+-dependent malate dehydrogenase | - |
Nitrosomonas europaea |
| NAD+-dependent malate dehydrogenase | - |
Corynebacterium glutamicum |
| NAD+-dependent malate dehydrogenase | - |
Streptomyces coelicolor |
| NAD+-dependent malate dehydrogenase | - |
Helicobacter pylori |
| NAD+-dependent malate dehydrogenase | - |
Kitasatospora aureofaciens |
| NAD+-dependent malate dehydrogenase | - |
Archaeoglobus fulgidus |
| NAD+-dependent malate dehydrogenase | - |
uncultured bacterium |
| NAD+-dependent malate dehydrogenase | - |
Glaesserella parasuis |
| NAD+-dependent malate dehydrogenase | - |
Aeropyrum pernix |
| NADP+-dependent malate dehydrogenase | - |
Methanocaldococcus jannaschii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Haloarcula marismortui | |
| NAD+ | - |
Bacillus subtilis | |
| NAD+ | - |
Methanothermobacter thermautotrophicus | |
| NAD+ | - |
Pseudomonas stutzeri | |
| NAD+ | - |
Nitrosomonas europaea | |
| NAD+ | - |
Corynebacterium glutamicum | |
| NAD+ | - |
Streptomyces coelicolor | |
| NAD+ | - |
Helicobacter pylori | |
| NAD+ | - |
Kitasatospora aureofaciens | |
| NAD+ | - |
Methanocaldococcus jannaschii | |
| NAD+ | - |
Archaeoglobus fulgidus | |
| NAD+ | - |
uncultured bacterium | |
| NAD+ | - |
Glaesserella parasuis | |
| NAD+ | - |
Aeropyrum pernix | |
| NAD+ | the ribose from NAD+ interacts with residues Gly10, Gly11, Ile12, Gly78, Val79, Asn119, Tyr33, Asp34, Ala77, Ile97, Leu101, Ser76, Ile117, Val146, and Met227 | Escherichia coli | |
| NADH | - |
Haloarcula marismortui | |
| NADH | - |
Bacillus subtilis | |
| NADH | - |
Escherichia coli | |
| NADH | - |
Methanothermobacter thermautotrophicus | |
| NADH | - |
Pseudomonas stutzeri | |
| NADH | - |
Nitrosomonas europaea | |
| NADH | - |
Corynebacterium glutamicum | |
| NADH | - |
Streptomyces coelicolor | |
| NADH | - |
Helicobacter pylori | |
| NADH | - |
Kitasatospora aureofaciens | |
| NADH | - |
Methanocaldococcus jannaschii | |
| NADH | - |
Archaeoglobus fulgidus | |
| NADH | - |
uncultured bacterium | |
| NADH | - |
Glaesserella parasuis | |
| NADH | - |
Aeropyrum pernix | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Escherichia coli | the enzyme expression is downregulated by the aerobic respiration control protein (ArcA), particularly under anaerobic conditions | down |
| Haloarcula marismortui | transcriptional regulation of mdh gene, overview | additional information |
| Bacillus subtilis | transcriptional regulation of mdh gene, overview | additional information |
| Methanothermobacter thermautotrophicus | transcriptional regulation of mdh gene, overview | additional information |
| Pseudomonas stutzeri | transcriptional regulation of mdh gene, overview | additional information |
| Nitrosomonas europaea | transcriptional regulation of mdh gene, overview | additional information |
| Corynebacterium glutamicum | transcriptional regulation of mdh gene, overview | additional information |
| Streptomyces coelicolor | transcriptional regulation of mdh gene, overview | additional information |
| Helicobacter pylori | transcriptional regulation of mdh gene, overview | additional information |
| Kitasatospora aureofaciens | transcriptional regulation of mdh gene, overview | additional information |
| Methanocaldococcus jannaschii | transcriptional regulation of mdh gene, overview | additional information |
| Archaeoglobus fulgidus | transcriptional regulation of mdh gene, overview | additional information |
| uncultured bacterium | transcriptional regulation of mdh gene, overview | additional information |
| Glaesserella parasuis | transcriptional regulation of mdh gene, overview | additional information |
| Aeropyrum pernix | transcriptional regulation of mdh gene, overview | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus. The other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Kitasatospora aureofaciens |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Haloarcula marismortui |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Bacillus subtilis |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Escherichia coli |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Methanothermobacter thermautotrophicus |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Pseudomonas stutzeri |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Nitrosomonas europaea |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Corynebacterium glutamicum |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Streptomyces coelicolor |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Helicobacter pylori |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Methanocaldococcus jannaschii |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Archaeoglobus fulgidus |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | uncultured bacterium |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Glaesserella parasuis |
| evolution | MDH is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms. The enzyme belongs to the superfamily of 2-ketoacid NAD(P)+-dependent dehydrogenases. MDH has diverged into two distinct phylogenetic groups. One group includes cytoplasmic MDH, chloroplast MDH, and MDH from Thermus flavus; the other group includes MDHs that are similar to lactate dehydrogenase (LDH). Structure comparisons, the MDHs are mostly dimeric or tetrameric, overview | Aeropyrum pernix |
| physiological function | regulation of MDH activity, overview | Haloarcula marismortui |
| physiological function | regulation of MDH activity, overview | Bacillus subtilis |
| physiological function | regulation of MDH activity, overview | Methanothermobacter thermautotrophicus |
| physiological function | regulation of MDH activity, overview | Pseudomonas stutzeri |
| physiological function | regulation of MDH activity, overview | Nitrosomonas europaea |
| physiological function | regulation of MDH activity, overview | Corynebacterium glutamicum |
| physiological function | regulation of MDH activity, overview | Streptomyces coelicolor |
| physiological function | regulation of MDH activity, overview | Helicobacter pylori |
| physiological function | regulation of MDH activity, overview | Kitasatospora aureofaciens |
| physiological function | regulation of MDH activity, overview | Methanocaldococcus jannaschii |
| physiological function | regulation of MDH activity, overview | Archaeoglobus fulgidus |
| physiological function | regulation of MDH activity, overview | uncultured bacterium |
| physiological function | regulation of MDH activity, overview | Glaesserella parasuis |
| physiological function | regulation of MDH activity, overview | Aeropyrum pernix |
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Release 2023.1 (January 2023)
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