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Literature summary for 1.1.1.37 extracted from

  • Wise, D.J.; Anderson, C.D.; Anderson, B.M.
    Purification and kinetic characterization of Haemophilus parasuis malate dehydrogenase (1997), Arch. Biochem. Biophys., 344, 176-183.
    View publication on PubMed

Application

Application Comment Organism
agriculture swine respiratory pathogen is the etiological agent of Glaesser's disease, swine industry economic losses worldwide Glaesserella parasuis

Inhibitors

Inhibitors Comment Organism Structure
3-Aminopyridine adenine dinucleotide
-
Glaesserella parasuis
3-methylpyridine adenine dinucleotide
-
Glaesserella parasuis
3-pyridylacetonitrile adenine dinucleotide
-
Glaesserella parasuis
3-pyridylcarbinol adenine dinucleotide
-
Glaesserella parasuis
adenosine
-
Glaesserella parasuis
adenosine 5'-diphosphoribose
-
Glaesserella parasuis
ADP
-
Glaesserella parasuis
AMP
-
Glaesserella parasuis
ATP
-
Glaesserella parasuis
Hydroxymalonate
-
Glaesserella parasuis
NAD+
-
Glaesserella parasuis
NADH product inhibition Glaesserella parasuis
pyridine adenine dinucleotide
-
Glaesserella parasuis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0165
-
NADH
-
Glaesserella parasuis
0.0667
-
3-acetylpyridine adenine dinucleotide
-
Glaesserella parasuis
0.072
-
oxaloacetate
-
Glaesserella parasuis
0.117
-
NAD+
-
Glaesserella parasuis
0.132
-
Thionicotinamide adenine dinucleotide
-
Glaesserella parasuis
0.19
-
pyridine 3-aldehyde adenine dinucleotide
-
Glaesserella parasuis
0.25
-
nicotinamide hypoxanthine dinucleotide
-
Glaesserella parasuis
0.55
-
malate
-
Glaesserella parasuis
1.464
-
nicotinamide 1-N6-ethenoadenine dinucleotide
-
Glaesserella parasuis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Glaesserella parasuis 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34600
-
2 * 34600, SDS-PAGE Glaesserella parasuis
68400
-
gel filtration Glaesserella parasuis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
malate + NAD+ Glaesserella parasuis
-
oxaloacetate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Glaesserella parasuis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Glaesserella parasuis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
222
-
-
Glaesserella parasuis

Storage Stability

Storage Stability Organism
-15°C, in 10 mM potassium phosphate buffer, pH 7.5, containing 0.1 M KCl, stable for at least 3 months with no apparent loss of activity Glaesserella parasuis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
Glaesserella parasuis oxaloacetate + NADH + H+
-
r
3-acetylpyridine adenine dinucleotide + L-malate
-
Glaesserella parasuis ?
-
?
malate + NAD+
-
Glaesserella parasuis oxaloacetate + NADH + H+
-
r
nicotinamide 1-N6-ethenoadenine dinucleotide + L-malate
-
Glaesserella parasuis ?
-
?
nicotinamide hypoxanthine dinucleotide + L-malate
-
Glaesserella parasuis ?
-
?
oxaloacetate + NADH
-
Glaesserella parasuis L-malate + NAD+
-
r
pyridine 3-aldehyde adenine dinucleotide + L-malate
-
Glaesserella parasuis ?
-
?
thionicotinamide adenine dinucleotide + L-malate
-
Glaesserella parasuis ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 34600, SDS-PAGE Glaesserella parasuis

Cofactor

Cofactor Comment Organism Structure
NAD+ NADP+ does not serve as a coenzyme Glaesserella parasuis