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Literature summary for 1.1.1.37 extracted from
- The nature of the substrate inhibition of cytoplasmic malate dehydrogenase from Phycomyces blakesleeanus (1984), Biochim. Biophys. Acta, 784, 158-163.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Phycomyces blakesleeanus |  |
| oxaloacetate | - |
Phycomyces blakesleeanus | |
| oxaloacetate | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
oxaloacetate | - |
Phycomyces blakesleeanus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Sus scrofa | 5737 | - |
| cytoplasm | - |
Phycomyces blakesleeanus | 5737 | - |
| cytoplasm | - |
Gallus sp. | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malate + NAD+ | Sus scrofa | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Cereibacter sphaeroides | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Phycomyces blakesleeanus | - |
oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | Gallus sp. | - |
oxaloacetate + NADH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cereibacter sphaeroides | - |
- |
- |
| Gallus sp. | - |
chicken | - |
| Phycomyces blakesleeanus | - |
wild-type strain NRRL 1555 (-) | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Phycomyces blakesleeanus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Sus scrofa | - |
| heart | - |
Gallus sp. | - |
| mycelium | - |
Phycomyces blakesleeanus | - |
| sporangiophore | - |
Phycomyces blakesleeanus | - |
| spore | - |
Phycomyces blakesleeanus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Cereibacter sphaeroides | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Phycomyces blakesleeanus | oxaloacetate + NADH + H+ | - |
r | |
| (S)-malate + NAD+ | - |
Gallus sp. | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Sus scrofa | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Cereibacter sphaeroides | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Phycomyces blakesleeanus | oxaloacetate + NADH + H+ | - |
r | |
| malate + NAD+ | - |
Gallus sp. | oxaloacetate + NADH + H+ | - |
r | |
| oxaloacetate + NADH | - |
Sus scrofa | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Cereibacter sphaeroides | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Phycomyces blakesleeanus | L-malate + NAD+ | - |
r | |
| oxaloacetate + NADH | - |
Gallus sp. | L-malate + NAD+ | - |
r | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 38 | - |
retains 100% activity after 45 min incubation, only 50% activity remains after 15 min at 45°C | Phycomyces blakesleeanus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9 | - |
Phycomyces blakesleeanus |
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