BRENDA - Enzyme Database show
show all sequences of 1.1.1.36

Methylobacterium rhodesianum MB 126 possesses two acetoacetyl-CoA reductases

Mothes, G.; Babel, W.; Arch. Microbiol. 161, 277-280 (1994)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
acetoacetyl-CoA
NADH-linked, less sensitive; NADPH-linked, concentration above 0.025 mM, nearly independent of NADPH concentrations 0.03-0.5 mM
Methylobacterium rhodesianum
acetoacetyl-CoA
-
Zoogloea ramigera
additional information
NADH-linked: not inhibited by NADPH at concentrations of 1 mM, NADPH-linked: not inhibited by NAD+ at concentrations of 1 mM
Methylobacterium rhodesianum
NAD+
NADH-linked
Methylobacterium rhodesianum
NADP+
-
Methylobacterium rhodesianum
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.015
-
acetoacetyl-CoA
cofactor NADPH
Methylobacterium rhodesianum
0.018
-
NADPH
-
Methylobacterium rhodesianum
0.022
-
L-beta-hydroxybutyryl-CoA
-
Methylobacterium rhodesianum
0.03
-
acetoacetyl-CoA
cofactor NADH
Methylobacterium rhodesianum
0.03
-
D-beta-hydroxybutyryl-CoA
-
Methylobacterium rhodesianum
0.06
-
NADP+
-
Methylobacterium rhodesianum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
NADH-linked enzyme: x * 55000, NADPH-linked enzyme: x * 42000, SDS-PAGE
Methylobacterium rhodesianum
250000
-
NADPH-linked: gel filtration
Methylobacterium rhodesianum
340000
-
NADH-linked: gel filtration
Methylobacterium rhodesianum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetoacetyl-CoA + NADH
Zoogloea ramigera
-
L-3-hydroxybutyryl-CoA + NAD+
-
Zoogloea ramigera
?
acetoacetyl-CoA + NADH
Rhodospirillum rubrum
-
L-3-hydroxybutyryl-CoA + NAD+
-
Rhodospirillum rubrum
?
acetoacetyl-CoA + NADPH
Zoogloea ramigera
PHB synthesis
D-3-hydroxybutyryl-CoA + NADP+
-
Zoogloea ramigera
-
acetoacetyl-CoA + NADPH
Rhodococcus ruber
PHB synthesis
D-3-hydroxybutyryl-CoA + NADP+
-
Rhodococcus ruber
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Methylobacterium rhodesianum
-
MB 126
-
Methylobacterium rhodesianum MB 126
-
MB 126
-
Rhodococcus ruber
-
-
-
Rhodospirillum rubrum
-
-
-
Zoogloea ramigera
-
-
-
Purification (Commentary)
Commentary
Organism
NADH-linked: DEAE-Sepharose CL-6B, Blue Sepharose CL-6B, botyl Sepharose 4B, Mono Q 5/5; NADPH-linked: DEAE-Sepharose CL-6B, Red 120-agarose, phenyle Sepharose
Methylobacterium rhodesianum
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
400
-
NADPH-linked
Methylobacterium rhodesianum
771
-
NADH-linked, 345 with NADPH
Methylobacterium rhodesianum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetoacetyl-CoA + NADH
reverse only with L-form
286623
Methylobacterium rhodesianum
L-beta-hydroxybutyryl-CoA + NAD+
-
286623
Methylobacterium rhodesianum
r
acetoacetyl-CoA + NADH
reverse only with L-form
286623
Methylobacterium rhodesianum MB 126
L-beta-hydroxybutyryl-CoA + NAD+
-
286623
Methylobacterium rhodesianum MB 126
r
acetoacetyl-CoA + NADH
-
286623
Zoogloea ramigera
L-3-hydroxybutyryl-CoA + NAD+
-
286623
Zoogloea ramigera
?
acetoacetyl-CoA + NADH
-
286623
Rhodospirillum rubrum
L-3-hydroxybutyryl-CoA + NAD+
-
286623
Rhodospirillum rubrum
?
acetoacetyl-CoA + NADPH
reverse only with D-form
286623
Methylobacterium rhodesianum
D-beta-hydroxybutyryl-CoA + NADP+
-
286623
Methylobacterium rhodesianum
r
acetoacetyl-CoA + NADPH
reverse only with D-form
286623
Methylobacterium rhodesianum MB 126
D-beta-hydroxybutyryl-CoA + NADP+
-
286623
Methylobacterium rhodesianum MB 126
r
acetoacetyl-CoA + NADPH
PHB synthesis
286623
Zoogloea ramigera
D-3-hydroxybutyryl-CoA + NADP+
-
286623
Zoogloea ramigera
-
acetoacetyl-CoA + NADPH
PHB synthesis
286623
Rhodococcus ruber
D-3-hydroxybutyryl-CoA + NADP+
-
286623
Rhodococcus ruber
?
Subunits
Subunits
Commentary
Organism
?
NADH-linked enzyme: x * 55000, NADPH-linked enzyme: x * 42000, SDS-PAGE
Methylobacterium rhodesianum
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
NADH-linked, reverse reaction pH 9.5; NADPH-linked, reverse reaction pH 10.0
Methylobacterium rhodesianum
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Methylobacterium rhodesianum
NADH
-
Rhodospirillum rubrum
NADH
-
Zoogloea ramigera
NADPH
-
Methylobacterium rhodesianum
NADPH
-
Rhodococcus ruber
NADPH
-
Zoogloea ramigera
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Methylobacterium rhodesianum
NADH
-
Rhodospirillum rubrum
NADH
-
Zoogloea ramigera
NADPH
-
Methylobacterium rhodesianum
NADPH
-
Rhodococcus ruber
NADPH
-
Zoogloea ramigera
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
acetoacetyl-CoA
NADH-linked, less sensitive; NADPH-linked, concentration above 0.025 mM, nearly independent of NADPH concentrations 0.03-0.5 mM
Methylobacterium rhodesianum
acetoacetyl-CoA
-
Zoogloea ramigera
additional information
NADH-linked: not inhibited by NADPH at concentrations of 1 mM, NADPH-linked: not inhibited by NAD+ at concentrations of 1 mM
Methylobacterium rhodesianum
NAD+
NADH-linked
Methylobacterium rhodesianum
NADP+
-
Methylobacterium rhodesianum
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.015
-
acetoacetyl-CoA
cofactor NADPH
Methylobacterium rhodesianum
0.018
-
NADPH
-
Methylobacterium rhodesianum
0.022
-
L-beta-hydroxybutyryl-CoA
-
Methylobacterium rhodesianum
0.03
-
acetoacetyl-CoA
cofactor NADH
Methylobacterium rhodesianum
0.03
-
D-beta-hydroxybutyryl-CoA
-
Methylobacterium rhodesianum
0.06
-
NADP+
-
Methylobacterium rhodesianum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
NADH-linked enzyme: x * 55000, NADPH-linked enzyme: x * 42000, SDS-PAGE
Methylobacterium rhodesianum
250000
-
NADPH-linked: gel filtration
Methylobacterium rhodesianum
340000
-
NADH-linked: gel filtration
Methylobacterium rhodesianum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetoacetyl-CoA + NADH
Zoogloea ramigera
-
L-3-hydroxybutyryl-CoA + NAD+
-
Zoogloea ramigera
?
acetoacetyl-CoA + NADH
Rhodospirillum rubrum
-
L-3-hydroxybutyryl-CoA + NAD+
-
Rhodospirillum rubrum
?
acetoacetyl-CoA + NADPH
Zoogloea ramigera
PHB synthesis
D-3-hydroxybutyryl-CoA + NADP+
-
Zoogloea ramigera
-
acetoacetyl-CoA + NADPH
Rhodococcus ruber
PHB synthesis
D-3-hydroxybutyryl-CoA + NADP+
-
Rhodococcus ruber
?
Purification (Commentary) (protein specific)
Commentary
Organism
NADH-linked: DEAE-Sepharose CL-6B, Blue Sepharose CL-6B, botyl Sepharose 4B, Mono Q 5/5; NADPH-linked: DEAE-Sepharose CL-6B, Red 120-agarose, phenyle Sepharose
Methylobacterium rhodesianum
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
400
-
NADPH-linked
Methylobacterium rhodesianum
771
-
NADH-linked, 345 with NADPH
Methylobacterium rhodesianum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetoacetyl-CoA + NADH
reverse only with L-form
286623
Methylobacterium rhodesianum
L-beta-hydroxybutyryl-CoA + NAD+
-
286623
Methylobacterium rhodesianum
r
acetoacetyl-CoA + NADH
reverse only with L-form
286623
Methylobacterium rhodesianum MB 126
L-beta-hydroxybutyryl-CoA + NAD+
-
286623
Methylobacterium rhodesianum MB 126
r
acetoacetyl-CoA + NADH
-
286623
Zoogloea ramigera
L-3-hydroxybutyryl-CoA + NAD+
-
286623
Zoogloea ramigera
?
acetoacetyl-CoA + NADH
-
286623
Rhodospirillum rubrum
L-3-hydroxybutyryl-CoA + NAD+
-
286623
Rhodospirillum rubrum
?
acetoacetyl-CoA + NADPH
reverse only with D-form
286623
Methylobacterium rhodesianum
D-beta-hydroxybutyryl-CoA + NADP+
-
286623
Methylobacterium rhodesianum
r
acetoacetyl-CoA + NADPH
reverse only with D-form
286623
Methylobacterium rhodesianum MB 126
D-beta-hydroxybutyryl-CoA + NADP+
-
286623
Methylobacterium rhodesianum MB 126
r
acetoacetyl-CoA + NADPH
PHB synthesis
286623
Zoogloea ramigera
D-3-hydroxybutyryl-CoA + NADP+
-
286623
Zoogloea ramigera
-
acetoacetyl-CoA + NADPH
PHB synthesis
286623
Rhodococcus ruber
D-3-hydroxybutyryl-CoA + NADP+
-
286623
Rhodococcus ruber
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
NADH-linked enzyme: x * 55000, NADPH-linked enzyme: x * 42000, SDS-PAGE
Methylobacterium rhodesianum
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
NADH-linked, reverse reaction pH 9.5; NADPH-linked, reverse reaction pH 10.0
Methylobacterium rhodesianum
Other publictions for EC 1.1.1.36
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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Beaudoin
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687159
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689821
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-
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Cupriavidus necator
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42
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8
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Streptococcus equi
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71
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669878
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Candida tropicalis
J. Mol. Biol.
358
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2006
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668057
Qiu
Production of poly(3-hydroxybu ...
Aeromonas hydrophila, Aeromonas hydrophila 4AK4, Pseudomonas putida
Biotechnol. Lett.
27
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2005
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654460
Ylianttila
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Candida tropicalis
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324
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656318
Satoh
Enzyme-catalyzed poly(3-hydrox ...
Cupriavidus necator
J. Biosci. Bioeng.
95
335-341
2003
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657106
Zhong
-
The pea (Pisum sativum L.) rbc ...
Cupriavidus necator
Plant Sci.
165
455-462
2003
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1
1
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657366
Haapalainen
Binary structure of the two-do ...
Rattus norvegicus
Structure
11
87-97
2003
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652075
Qin
Human peroxisomal multifunctio ...
Homo sapiens
J. Biol. Chem.
275
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2000
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Houmiel
Poly(beta-hydroxybutyrate) pro ...
Cupriavidus necator
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1999
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Qin
Yeast peroxisomal multifunctio ...
Candida tropicalis, Homo sapiens, Saccharomyces cerevisiae
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1999
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Qin
Peroxisomal multifunctional en ...
Rattus norvegicus
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1997
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286622
Belova
-
Purification and characterizat ...
Azotobacter vinelandii, Cupriavidus necator, Methylobacterium extorquens, Methylobacterium extorquens 15, Methylobacterium rhodesianum, Methylobacterium rhodesianum MB 126, Rhodospirillum rubrum, Zoogloea ramigera
FEMS Microbiol. Lett.
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275-279
1997
4
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286624
Gerngross
Enzyme-catalyzed synthesis of ...
Cupriavidus necator
Proc. Natl. Acad. Sci. USA
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6279-6283
1995
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286623
Mothes
-
Methylobacterium rhodesianum M ...
Methylobacterium rhodesianum, Methylobacterium rhodesianum MB 126, Rhodococcus ruber, Rhodospirillum rubrum, Zoogloea ramigera
Arch. Microbiol.
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277-280
1994
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286621
Amos
-
Formation of D-3-hydroxybutyry ...
Azotobacter beijerinckii, Cupriavidus necator, Syntrophomonas wolfei, Zoogloea ramigera
Arch. Microbiol.
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16-20
1993
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687487
Hiltunen
Peroxisomal multifunctional be ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae fox2
J. Biol. Chem.
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1992
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286620
Ploux
The NADPH-linked acetoacetyl-C ...
Zoogloea ramigera
Eur. J. Biochem.
174
177-182
1988
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286619
Fukui
Purification and characterizat ...
Pigeon, Zoogloea ramigera
Biochim. Biophys. Acta
917
365-371
1987
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286618
Cook
Isolation of rat liver microso ...
Rattus norvegicus
Arch. Biochem. Biophys.
246
206-216
1986
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286617
Prasad
Rat hepatic microsomal acetoac ...
Rattus norvegicus
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7460-7467
1984
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286615
Dodds
Acetoacetyl-CoA reductase acti ...
Anser sp., Bos taurus, Gallus gallus, Pigeon, Rattus norvegicus, Saccharomyces cerevisiae
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256
6282-6290
1981
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286614
Saito
An NADP-linked acetoacetyl CoA ...
Azotobacter beijerinckii, Zoogloea ramigera
Arch. Microbiol.
114
211-217
1977
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Packter
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Characterization of acetoacety ...
Streptomyces coelicolor
Biochem. Soc. Trans.
11
598-599
1973
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286613
Wakil
Studies on the mechanism of fa ...
Pigeon
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687-693
1962
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