BRENDA - Enzyme Database show
show all sequences of 1.1.1.36

Acetoacetyl-CoA reductase activity of lactating bovine mammary fatty acid synthase

Dodds, P.F.; Guzman, M.G.F.; Chalberg, S.C.; Anderson, G.J.; Kumar, S.; J. Biol. Chem. 256, 6282-6290 (1981)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
CoA
stimulating
Bos taurus
CoA
stimulating
Rattus norvegicus
pantetheine
stimulating
Bos taurus
pantetheine
stimulating
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-methylcrotonyl-CoA
-
Anser sp.
2-methylcrotonyl-CoA
-
Bos taurus
2-methylcrotonyl-CoA
-
Gallus gallus
2-methylcrotonyl-CoA
-
Pigeon
2-methylcrotonyl-CoA
-
Rattus norvegicus
2-methylcrotonyl-CoA
-
Saccharomyces cerevisiae
acetyl-CoA
-
Anser sp.
acetyl-CoA
-
Bos taurus
acetyl-CoA
-
Gallus gallus
acetyl-CoA
-
Pigeon
acetyl-CoA
-
Rattus norvegicus
acetyl-CoA
-
Saccharomyces cerevisiae
butyryl-CoA
-
Anser sp.
butyryl-CoA
-
Bos taurus
butyryl-CoA
-
Gallus gallus
butyryl-CoA
-
Pigeon
butyryl-CoA
-
Rattus norvegicus
butyryl-CoA
-
Saccharomyces cerevisiae
iodoacetamide
-
Anser sp.
iodoacetamide
-
Bos taurus
iodoacetamide
-
Gallus gallus
iodoacetamide
-
Pigeon
iodoacetamide
-
Rattus norvegicus
iodoacetamide
-
Saccharomyces cerevisiae
malonyl-CoA
-
Anser sp.
malonyl-CoA
-
Bos taurus
malonyl-CoA
-
Gallus gallus
malonyl-CoA
-
Pigeon
malonyl-CoA
-
Rattus norvegicus
malonyl-CoA
-
Saccharomyces cerevisiae
methylmalonyl-CoA
-
Anser sp.
methylmalonyl-CoA
-
Bos taurus
methylmalonyl-CoA
-
Gallus gallus
methylmalonyl-CoA
-
Pigeon
methylmalonyl-CoA
-
Rattus norvegicus
methylmalonyl-CoA
-
Saccharomyces cerevisiae
N-Methylmaleimide
-
Anser sp.
N-Methylmaleimide
-
Bos taurus
N-Methylmaleimide
-
Gallus gallus
N-Methylmaleimide
-
Pigeon
N-Methylmaleimide
-
Rattus norvegicus
N-Methylmaleimide
-
Saccharomyces cerevisiae
N-Phenylmaleimide
-
Anser sp.
N-Phenylmaleimide
-
Bos taurus
N-Phenylmaleimide
-
Gallus gallus
N-Phenylmaleimide
-
Pigeon
N-Phenylmaleimide
-
Rattus norvegicus
N-Phenylmaleimide
-
Saccharomyces cerevisiae
sulfhydryl reagents
-
Anser sp.
sulfhydryl reagents
-
Bos taurus
sulfhydryl reagents
-
Gallus gallus
sulfhydryl reagents
-
Pigeon
sulfhydryl reagents
-
Rattus norvegicus
sulfhydryl reagents
-
Saccharomyces cerevisiae
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.005
-
acetoacetyl-CoA
-
Bos taurus
0.005
-
acetoacetyl-CoA
-
Rattus norvegicus
0.04
-
S-acetoacetyl-N-acetylcysteamine
-
Bos taurus
0.82
-
acetoacetyl-pantetheine
-
Bos taurus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Anser sp.
-
low activity
-
Bos taurus
-
-
-
Gallus gallus
-
low activity
-
Pigeon
-
low activity
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
low activity
-
Purification (Commentary)
Commentary
Organism
-
Bos taurus
-
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adipose tissue
-
Rattus norvegicus
-
liver
-
Gallus gallus
-
liver
-
Rattus norvegicus
-
liver
-
Pigeon
-
mammary gland
-
Bos taurus
-
mammary gland
-
Rattus norvegicus
-
uropygial gland
-
Anser sp.
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetoacetyl-CoA + NADPH + H+
-
286615
Rattus norvegicus
(3R)-3-hydroxybutyryl-CoA + NADP+
-
-
-
ir
acetoacetyl-CoA + NADPH + H+
-
286615
Bos taurus
(3R)-3-hydroxybutyryl-CoA + NADP+
-
-
-
ir
acetoacetyl-CoA + NADPH + H+
-
286615
Pigeon
(3R)-3-hydroxybutyryl-CoA + NADP+
-
-
-
-
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Gallus gallus
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Gallus gallus
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Rattus norvegicus
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Rattus norvegicus
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Saccharomyces cerevisiae
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Saccharomyces cerevisiae
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Bos taurus
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Bos taurus
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Pigeon
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Pigeon
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Anser sp.
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Anser sp.
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Anser sp.
NADP+
-
Bos taurus
NADP+
-
Gallus gallus
NADP+
-
Saccharomyces cerevisiae
NADP+
-
Rattus norvegicus
NADP+
-
Pigeon
NADPH
specific for
Anser sp.
NADPH
specific for
Bos taurus
NADPH
specific for
Gallus gallus
NADPH
specific for
Rattus norvegicus
NADPH
specific for
Saccharomyces cerevisiae
NADPH
specific for
Pigeon
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
CoA
stimulating
Bos taurus
CoA
stimulating
Rattus norvegicus
pantetheine
stimulating
Bos taurus
pantetheine
stimulating
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Anser sp.
NADP+
-
Bos taurus
NADP+
-
Gallus gallus
NADP+
-
Saccharomyces cerevisiae
NADP+
-
Rattus norvegicus
NADP+
-
Pigeon
NADPH
specific for
Anser sp.
NADPH
specific for
Bos taurus
NADPH
specific for
Gallus gallus
NADPH
specific for
Rattus norvegicus
NADPH
specific for
Saccharomyces cerevisiae
NADPH
specific for
Pigeon
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-methylcrotonyl-CoA
-
Anser sp.
2-methylcrotonyl-CoA
-
Bos taurus
2-methylcrotonyl-CoA
-
Gallus gallus
2-methylcrotonyl-CoA
-
Pigeon
2-methylcrotonyl-CoA
-
Rattus norvegicus
2-methylcrotonyl-CoA
-
Saccharomyces cerevisiae
acetyl-CoA
-
Anser sp.
acetyl-CoA
-
Bos taurus
acetyl-CoA
-
Gallus gallus
acetyl-CoA
-
Pigeon
acetyl-CoA
-
Rattus norvegicus
acetyl-CoA
-
Saccharomyces cerevisiae
butyryl-CoA
-
Anser sp.
butyryl-CoA
-
Bos taurus
butyryl-CoA
-
Gallus gallus
butyryl-CoA
-
Pigeon
butyryl-CoA
-
Rattus norvegicus
butyryl-CoA
-
Saccharomyces cerevisiae
iodoacetamide
-
Anser sp.
iodoacetamide
-
Bos taurus
iodoacetamide
-
Gallus gallus
iodoacetamide
-
Pigeon
iodoacetamide
-
Rattus norvegicus
iodoacetamide
-
Saccharomyces cerevisiae
malonyl-CoA
-
Anser sp.
malonyl-CoA
-
Bos taurus
malonyl-CoA
-
Gallus gallus
malonyl-CoA
-
Pigeon
malonyl-CoA
-
Rattus norvegicus
malonyl-CoA
-
Saccharomyces cerevisiae
methylmalonyl-CoA
-
Anser sp.
methylmalonyl-CoA
-
Bos taurus
methylmalonyl-CoA
-
Gallus gallus
methylmalonyl-CoA
-
Pigeon
methylmalonyl-CoA
-
Rattus norvegicus
methylmalonyl-CoA
-
Saccharomyces cerevisiae
N-Methylmaleimide
-
Anser sp.
N-Methylmaleimide
-
Bos taurus
N-Methylmaleimide
-
Gallus gallus
N-Methylmaleimide
-
Pigeon
N-Methylmaleimide
-
Rattus norvegicus
N-Methylmaleimide
-
Saccharomyces cerevisiae
N-Phenylmaleimide
-
Anser sp.
N-Phenylmaleimide
-
Bos taurus
N-Phenylmaleimide
-
Gallus gallus
N-Phenylmaleimide
-
Pigeon
N-Phenylmaleimide
-
Rattus norvegicus
N-Phenylmaleimide
-
Saccharomyces cerevisiae
sulfhydryl reagents
-
Anser sp.
sulfhydryl reagents
-
Bos taurus
sulfhydryl reagents
-
Gallus gallus
sulfhydryl reagents
-
Pigeon
sulfhydryl reagents
-
Rattus norvegicus
sulfhydryl reagents
-
Saccharomyces cerevisiae
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.005
-
acetoacetyl-CoA
-
Bos taurus
0.005
-
acetoacetyl-CoA
-
Rattus norvegicus
0.04
-
S-acetoacetyl-N-acetylcysteamine
-
Bos taurus
0.82
-
acetoacetyl-pantetheine
-
Bos taurus
Purification (Commentary) (protein specific)
Commentary
Organism
-
Bos taurus
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adipose tissue
-
Rattus norvegicus
-
liver
-
Gallus gallus
-
liver
-
Rattus norvegicus
-
liver
-
Pigeon
-
mammary gland
-
Bos taurus
-
mammary gland
-
Rattus norvegicus
-
uropygial gland
-
Anser sp.
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetoacetyl-CoA + NADPH + H+
-
286615
Rattus norvegicus
(3R)-3-hydroxybutyryl-CoA + NADP+
-
-
-
ir
acetoacetyl-CoA + NADPH + H+
-
286615
Bos taurus
(3R)-3-hydroxybutyryl-CoA + NADP+
-
-
-
ir
acetoacetyl-CoA + NADPH + H+
-
286615
Pigeon
(3R)-3-hydroxybutyryl-CoA + NADP+
-
-
-
-
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Gallus gallus
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Gallus gallus
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Rattus norvegicus
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Rattus norvegicus
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Saccharomyces cerevisiae
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Saccharomyces cerevisiae
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Bos taurus
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Bos taurus
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Pigeon
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Pigeon
?
S-acetoacetyl-N-acetylcysteamine + NADPH
-
286615
Anser sp.
3-hydroxybutyryl-N-acetylcysteamine + NADP+
-
286615
Anser sp.
?
Other publictions for EC 1.1.1.36
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
700827
Beaudoin
Functional characterization of ...
Arabidopsis thaliana
Plant Physiol.
150
1174-1191
2009
-
-
1
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
6
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
6
1
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
701808
Han
Identification of the polyhydr ...
Haloarcula hispanica, Haloarcula hispanica DSM 4426
Appl. Environ. Microbiol.
75
6168-6175
2009
-
-
1
-
1
-
-
-
-
-
-
2
-
7
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684617
Liu
Microbial production of R-3-hy ...
Cupriavidus necator, no activity in Escherichia coli, no activity in Escherichia coli DH5-alpha
Appl. Microbiol. Biotechnol.
76
811-818
2007
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687159
Abd-El-haleem
-
Biosynthesis of biodegradable ...
Cupriavidus necator
Int. J. Environ. Sci. Technol.
4
513-520
2007
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689821
Zhao
-
Production and characterizatio ...
Cupriavidus necator
Process Biochem.
42
1342-1347
2007
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667282
Qiu
Metabolic engineering of Aerom ...
Aeromonas hydrophila, Cupriavidus necator
Appl. Microbiol. Biotechnol.
69
537-542
2006
-
-
-
-
-
-
-
-
-
-
1
-
-
8
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667285
Zhang
Effect of expressing polyhydro ...
Streptococcus equi
Appl. Microbiol. Biotechnol.
71
222-227
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669878
Ylianttila
Crystal structure of yeast per ...
Candida tropicalis
J. Mol. Biol.
358
1286-1295
2006
-
-
1
1
-
-
-
-
1
-
-
-
-
5
-
-
1
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668057
Qiu
Production of poly(3-hydroxybu ...
Aeromonas hydrophila, Aeromonas hydrophila 4AK4, Pseudomonas putida
Biotechnol. Lett.
27
1381-1386
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654460
Ylianttila
Site-directed mutagenesis to e ...
Candida tropicalis
Biochem. Biophys. Res. Commun.
324
25-30
2004
-
-
1
1
1
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656318
Satoh
Enzyme-catalyzed poly(3-hydrox ...
Cupriavidus necator
J. Biosci. Bioeng.
95
335-341
2003
-
1
1
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
1
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
657106
Zhong
-
The pea (Pisum sativum L.) rbc ...
Cupriavidus necator
Plant Sci.
165
455-462
2003
-
1
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657366
Haapalainen
Binary structure of the two-do ...
Rattus norvegicus
Structure
11
87-97
2003
-
-
1
1
-
-
-
-
2
-
-
3
-
2
-
-
1
1
-
-
-
-
3
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
2
-
-
3
-
-
-
1
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652075
Qin
Human peroxisomal multifunctio ...
Homo sapiens
J. Biol. Chem.
275
4965-4972
2000
-
-
1
-
14
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
14
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286625
Houmiel
Poly(beta-hydroxybutyrate) pro ...
Cupriavidus necator
Planta
209
547-550
1999
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687492
Qin
Yeast peroxisomal multifunctio ...
Candida tropicalis, Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
274
28619-28625
1999
-
-
1
-
6
-
-
5
4
-
-
-
-
6
-
-
1
-
-
-
5
-
3
-
-
-
-
8
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
5
4
-
-
-
-
-
-
1
-
-
5
-
3
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
33732
Qin
Peroxisomal multifunctional en ...
Rattus norvegicus
Biochem. J.
321
21-28
1997
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286622
Belova
-
Purification and characterizat ...
Azotobacter vinelandii, Cupriavidus necator, Methylobacterium extorquens, Methylobacterium extorquens 15, Methylobacterium rhodesianum, Methylobacterium rhodesianum MB 126, Rhodospirillum rubrum, Zoogloea ramigera
FEMS Microbiol. Lett.
156
275-279
1997
4
-
-
-
-
-
12
14
2
-
7
6
-
9
-
-
1
-
-
-
1
1
9
2
2
-
-
-
1
-
-
5
-
-
-
4
-
-
5
-
-
-
-
12
-
14
2
-
7
6
-
-
-
1
-
-
1
1
9
2
2
-
-
-
1
-
-
-
-
-
-
-
-
-
286624
Gerngross
Enzyme-catalyzed synthesis of ...
Cupriavidus necator
Proc. Natl. Acad. Sci. USA
92
6279-6283
1995
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286623
Mothes
-
Methylobacterium rhodesianum M ...
Methylobacterium rhodesianum, Methylobacterium rhodesianum MB 126, Rhodococcus ruber, Rhodospirillum rubrum, Zoogloea ramigera
Arch. Microbiol.
161
277-280
1994
-
-
-
-
-
-
5
6
-
-
3
4
-
6
-
-
1
-
-
-
2
-
8
1
-
-
-
-
1
-
-
6
-
-
-
-
-
-
6
-
-
-
-
5
-
6
-
-
3
4
-
-
-
1
-
-
2
-
8
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286621
Amos
-
Formation of D-3-hydroxybutyry ...
Azotobacter beijerinckii, Cupriavidus necator, Syntrophomonas wolfei, Zoogloea ramigera
Arch. Microbiol.
159
16-20
1993
-
-
-
-
-
-
-
-
2
-
-
5
-
4
-
-
1
-
-
-
3
-
7
-
-
-
-
-
1
1
-
11
-
-
-
-
-
-
11
-
-
-
-
-
-
-
2
-
-
5
-
-
-
1
-
-
3
-
7
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
687487
Hiltunen
Peroxisomal multifunctional be ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae fox2
J. Biol. Chem.
267
6646-6653
1992
-
-
-
-
1
-
-
-
-
-
-
2
-
6
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286620
Ploux
The NADPH-linked acetoacetyl-C ...
Zoogloea ramigera
Eur. J. Biochem.
174
177-182
1988
-
-
1
-
-
-
2
7
1
-
3
1
-
4
-
-
1
-
-
-
1
-
6
1
-
-
-
6
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
2
-
7
1
-
3
1
-
-
-
1
-
-
1
-
6
1
-
-
-
6
-
-
-
-
-
-
-
-
-
-
286619
Fukui
Purification and characterizat ...
Pigeon, Zoogloea ramigera
Biochim. Biophys. Acta
917
365-371
1987
-
-
-
-
-
1
1
-
-
-
2
-
1
4
-
-
1
-
-
2
1
2
7
1
1
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
1
-
1
-
-
-
-
2
-
1
-
-
1
-
2
1
2
7
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
286618
Cook
Isolation of rat liver microso ...
Rattus norvegicus
Arch. Biochem. Biophys.
246
206-216
1986
-
-
-
-
-
-
-
2
1
-
1
-
-
1
-
-
1
-
-
1
2
1
2
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
2
1
-
1
-
-
-
-
1
-
1
2
1
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
286617
Prasad
Rat hepatic microsomal acetoac ...
Rattus norvegicus
J. Biol. Chem.
259
7460-7467
1984
-
-
-
-
-
-
-
2
2
-
-
-
-
2
-
-
1
-
-
2
-
-
2
-
1
-
-
-
1
-
1
3
-
-
-
-
-
-
3
-
-
-
-
-
-
2
2
-
-
-
-
-
-
1
-
2
-
-
2
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
286615
Dodds
Acetoacetyl-CoA reductase acti ...
Anser sp., Bos taurus, Gallus gallus, Pigeon, Rattus norvegicus, Saccharomyces cerevisiae
J. Biol. Chem.
256
6282-6290
1981
4
-
-
-
-
-
54
4
-
-
-
-
-
10
-
-
2
-
-
7
-
-
9
-
-
-
-
-
-
-
-
12
-
-
-
4
-
-
12
-
-
-
-
54
-
4
-
-
-
-
-
-
-
2
-
7
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286614
Saito
An NADP-linked acetoacetyl CoA ...
Azotobacter beijerinckii, Zoogloea ramigera
Arch. Microbiol.
114
211-217
1977
-
-
-
-
-
-
1
2
-
-
-
4
-
3
-
-
1
-
-
-
1
-
6
-
1
-
-
-
1
-
-
6
-
-
-
-
-
-
6
-
-
-
-
1
-
2
-
-
-
4
-
-
-
1
-
-
1
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286616
Packter
-
Characterization of acetoacety ...
Streptomyces coelicolor
Biochem. Soc. Trans.
11
598-599
1973
-
-
-
-
-
-
1
3
-
-
3
-
-
1
-
-
1
-
-
-
-
-
3
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
3
-
-
3
-
-
-
-
1
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286613
Wakil
Studies on the mechanism of fa ...
Pigeon
J. Biol. Chem.
237
687-693
1962
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
-
-
1
3
-
5
-
1
-
-
-
-
1
1
2
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
3
-
5
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-