Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP-activated protein kinase | - |
Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | lack of Hadh2 activity may impart early developmental problems, leading to embryo lethality. In addition to the 3-hydroxyacyl-CoA dehydrogenase activity, the HSD10 (formerly Hadh2) activity is also relevant to the metabolism and meiotic maturation of oocytes | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | in oocytes from diabetic mice, activity of Hadh2 is significantly reduced | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetoacetyl-CoA + NADH + H+ | for the purpose of specifically measuring intracellular Hadh2 activities, branched-chain acyl-CoA thioesters, instead of acetoacetyl-CoA, shall be used as the substrate in either the forward or reverse reaction. In contrast to 3-hydroxyacyl-CoA dehydrogenase catalyzing the third reaction of straight-chain fatty acid oxidation spiral, HSD10 (formerly Hadh2) functions in isoleucine and steroid metabolism | Mus musculus | 3-hydroxybutyryl-CoA + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxyacyl-CoA dehydrogenase | - |
Mus musculus |
3-hydroxyacyl-CoA dehydrogenase II | - |
Mus musculus |
HADH | - |
Mus musculus |
HADH2 | - |
Mus musculus |