Application | Comment | Organism |
---|---|---|
pharmacology | the short-chain 3-hydroxyacyl-CoA dehydrogenase is a target for intervention in case of Alzheimer's disease and Parkinson's disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Sus scrofa | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is essentially involved in mitochondrial fatty acid beta-oxidation by catalyzing straight chain 3-hydroxyacyl-CoAs, the enzyme plays a role in Alzheimer's disease and Parkinson's disease, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16836 | - |
- |
Sus scrofa | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+ | molecular reaction mechanism, a His-Glu pair is essential for actalysis in the active site | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxy-2-methylacyl-CoA + NAD+ | preferred substrate of SCHAD, no activity towards 3-hydroxy-2-methylacyl-CoA by HAD | Sus scrofa | 3-oxo-2-methylacyl-CoA + NADH | - |
? | |
additional information | the enzyme is essentially involved in mitochondrial fatty acid beta-oxidation by catalyzing straight chain 3-hydroxyacyl-CoAs, the enzyme plays a role in Alzheimer's disease and Parkinson's disease, overview | Homo sapiens | ? | - |
? | |
additional information | short-chain L-3-hydroxyacyl-CoA dehydrogenase shows a wide substrate spectrum including cholic acids, steroids, and fatty acids with a preference for short-chain methyl-branched acyl-CoAs, SCHAD might be identical with 17beta-hydroxysteroid dehyxrogenase in human mitochondria, overview | Homo sapiens | ? | - |
? | |
tiglyl-CoA + NAD+ | activity of SCHAD | Sus scrofa | 3-oxo-2-methylacyl-CoA + NADH | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | primary structure analysis, structure-function relationship of SCHAD, overview | Sus scrofa |
More | structure-function relationship of SCHAD, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxyacyl-CoA dehydrogenase | - |
Sus scrofa |
3-hydroxyacyl-CoA dehydrogenase | - |
Homo sapiens |
SCHAD | - |
Sus scrofa |
SCHAD | - |
Homo sapiens |
short-chain 3-hydroxyacyl-CoA dehydrogenase | - |
Sus scrofa |
short-chain 3-hydroxyacyl-CoA dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Sus scrofa | |
NAD+ | dependent on | Homo sapiens |