BRENDA - Reference to 1.1.1.35; Id = 673340

mitochondrion

-

Homo sapiens

5739

-

17beta-estradiol + NAD+

Homo sapiens

inactivation

estrone + NADH + H+

-

?

5alpha-androstane-3,17-diol + NAD+

Homo sapiens

inactivation

5alpha-dihydrotestosterone + NADH

-

?

allopregnanolone + NAD+

Homo sapiens

inactivation

5alpha-dihydroprogesterone + NADH

-

?

additional information

Homo sapiens

the enzyme is involved in intracrinology and is essential for the metabolism of isoleucine and branched-chain fatty acids

?

-

Homo sapiens

-

astrocyte

activated, high level expression

Homo sapiens

-

brain

-

Homo sapiens

-

heart

-

Homo sapiens

-

liver

-

Homo sapiens

-

additional information

wide tissue distribution

Homo sapiens

-

prostate

-

Homo sapiens

-

prostate cancer cell

high level expression in malignant prostatic epithelial cells

Homo sapiens

-

17beta-estradiol + NAD+

-

673340

Homo sapiens

estrone + NADH + H+

-

?

17beta-estradiol + NAD+

inactivation

673340

Homo sapiens

estrone + NADH + H+

-

?

5alpha-androstane-3,17-diol + NAD+

-

673340

Homo sapiens

5alpha-dihydrotestosterone + NADH

-

?

5alpha-androstane-3,17-diol + NAD+

inactivation

673340

Homo sapiens

5alpha-dihydrotestosterone + NADH

-

?

allopregnanolone + NAD+

-

673340

Homo sapiens

5alpha-dihydroprogesterone + NADH

-

?

allopregnanolone + NAD+

inactivation

673340

Homo sapiens

5alpha-dihydroprogesterone + NADH

-

?

additional information

the enzyme is involved in intracrinology and is essential for the metabolism of isoleucine and branched-chain fatty acids

673340

Homo sapiens

?

-

NAD+

-

Homo sapiens

NAD+

-

Homo sapiens

mitochondrion

-

Homo sapiens

5739

-

17beta-estradiol + NAD+

Homo sapiens

inactivation

estrone + NADH + H+

-

?

5alpha-androstane-3,17-diol + NAD+

Homo sapiens

inactivation

5alpha-dihydrotestosterone + NADH

-

?

allopregnanolone + NAD+

Homo sapiens

inactivation

5alpha-dihydroprogesterone + NADH

-

?

additional information

Homo sapiens

the enzyme is involved in intracrinology and is essential for the metabolism of isoleucine and branched-chain fatty acids

?

-

astrocyte

activated, high level expression

Homo sapiens

-

brain

-

Homo sapiens

-

heart

-

Homo sapiens

-

liver

-

Homo sapiens

-

additional information

wide tissue distribution

Homo sapiens

-

prostate

-

Homo sapiens

-

prostate cancer cell

high level expression in malignant prostatic epithelial cells

Homo sapiens

-

17beta-estradiol + NAD+

-

673340

Homo sapiens

estrone + NADH + H+

-

?

17beta-estradiol + NAD+

inactivation

673340

Homo sapiens

estrone + NADH + H+

-

?

5alpha-androstane-3,17-diol + NAD+

-

673340

Homo sapiens

5alpha-dihydrotestosterone + NADH

-

?

5alpha-androstane-3,17-diol + NAD+

inactivation

673340

Homo sapiens

5alpha-dihydrotestosterone + NADH

-

?

allopregnanolone + NAD+

-

673340

Homo sapiens

5alpha-dihydroprogesterone + NADH

-

?

allopregnanolone + NAD+

inactivation

673340

Homo sapiens

5alpha-dihydroprogesterone + NADH

-

?

additional information

the enzyme is involved in intracrinology and is essential for the metabolism of isoleucine and branched-chain fatty acids

673340

Homo sapiens

?

-

729651

Schmid

Enzymes of the benzoyl-coenzym ...

Ferroglobus placidus, Ferroglobus placidus DSM 10642

Environ. Microbiol.

17

3289-3300

2015

-

1

-

2

-

2

-

1

-

4

-

1

-

1

-

2

-

1

-

4

-

1

-

1

-

726748

Hawkins

Conversion of 4-hydroxybutyrat ...

Metallosphaera sedula, Metallosphaera sedula DSM 5348

Appl. Environ. Microbiol.

80

2536-2545

2014

-

1

-

1

-

2

-

3

-

4

-

1

-

1

-

1

-

1

-

1

-

2

-

4

-

1

-

1

-

1

-

1

739812

Kim

Cloning, expression, purificat ...

Clostridium butyricum

Acta Crystallogr. Sect. F

70

485-488

2014

-

1

-

1

-

2

-

1

-

1

-

2

-

1

2

1

-

1

-

1

-

1

-

1

-

739815

Kim

Cloning, expression, purificat ...

Cupriavidus necator, Cupriavidus necator ATCC 17699

Acta Crystallogr. Sect. F

70

955-958

2014

-

1

-

2

-

5

-

1

-

2

-

2

-

1

2

1

-

2

-

1

-

2

-

1

-

739840

Volodina

(S)-3-hydroxyacyl-CoA dehydrog ...

Cupriavidus necator, Cupriavidus necator DSM 428

AMB Express

4

69

2014

-

1

-

3

2

-

1

2

-

4

-

1

-

2

-

8

2

1

-

1

-

5

-

1

-

1

5

-

3

-

2

-

1

2

-

1

-

2

-

8

2

1

-

1

-

1

-

3

-

739989

Kim

Crystal structure and biochemi ...

Cupriavidus necator, Cupriavidus necator ATCC 17699

Biochem. Biophys. Res. Commun.

448

163-168

2014

-

1

4

-

2

-

2

-

5

-

1

-

4

-

1

-

1

-

2

-

1

2

1

4

-

2

-

2

-

1

-

4

-

1

-

1

-

1

-

740235

Segawa

Identification of leptospiral ...

Leptospira interrogans serovar Copenhageni, Leptospira interrogans serovar Copenhageni Fiocruz LV4231

BMC Microbiol.

14

132

2014

-

1

-

1

-

2

-

4

-

1

-

2

-

2

1

-

1

-

1

-

1

-

2

-

1

-

2

-

2

1

-

2

-

740854

Kim

Crystal structure of (S)-3-hyd ...

Clostridium butyricum

J. Microbiol. Biotechnol.

24

1636-1643

2014

-

2

1

8

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

2

1

2

1

8

-

1

-

1

-

1

-

1

-

1

-

2

-

741307

Xu

Dimerization interface of 3-hy ...

Caenorhabditis elegans, Homo sapiens

PLoS ONE

9

e95965

2014

-

1

8

-

4

2

-

2

-

4

-

1

2

-

3

2

1

-

4

1

-

3

-

1

3

1

8

-

4

2

-

2

-

1

-

3

2

1

-

4

1

-

8

-

3

739806

Xu

Purification, crystallization ...

Caenorhabditis elegans

Acta Crystallogr. Sect. F

69

515-519

2013

-

1

-

1

-

1

-

3

-

1

-

1

-

2

-

1

2

1

-

1

-

1

-

1

-

1

-

2

-

740804

Heslegrave

Novel insights into fatty acid ...

Homo sapiens

J. Clin. Endocrinol. Metab.

98

496-501

2013

-

4

-

1

-

2

-

4

-

1

-

2

-

2

-

4

-

1

-

4

-

1

-

2

-

723558

Narayan

Short-chain 3-hydroxyacyl-coen ...

Mus musculus

PLoS ONE

7

e35048

2012

-

1

-

1

-

3

-

3

-

1

-

1

-

3

-

2

-

722124

Schulz

Role of medium- and short-chai ...

Mus musculus

Endocrinology

152

4641-4651

2011

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

3

-

727751

Ramos-Vera

Identification of missing gene ...

Metallosphaera sedula, Metallosphaera sedula DSM 5348

J. Bacteriol.

193

1201-1211

2011

-

1

-

2

-

1

2

-

3

-

1

-

2

1

-

4

1

-

1

-

1

-

1

-

2

-

1

2

-

1

-

2

1

-

4

1

-

1

-

1

-

712966

Taylor

Characterization of a beta-hyd ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618

Microbiology

156

1975-1982

2010

-

1

-

5

4

-

2

-

2

-

5

-

1

-

8

-

1

-

4

2

1

-

3

-

2

-

1

3

-

5

-

4

-

2

-

2

-

1

-

8

-

1

-

4

2

1

-

2

-

2

-

716755

Teufel

Bacterial phenylalanine and ph ...

Escherichia coli, Pseudomonas sp., Pseudomonas sp. Y2

Proc. Natl. Acad. Sci. USA

107

14390-14395

2010

-

3

-

5

-

3

-

2

-

2

-

3

-

3

-

2

-

695832

Chung

Microbial production of 3-hydr ...

Pseudomonas putida

Appl. Microbiol. Biotechnol.

83

513-519

2009

-

1

-

3

-

1

-

699171

Kapoor

3-Hydroxyacyl-coenzyme A dehyd ...

Homo sapiens

J. Clin. Endocrinol. Metab.

94

2221-2225

2009

-

1

-

2

-

1

-

4

-

1

-

1

-

4

-

700827

Beaudoin

Functional characterization of ...

Arabidopsis thaliana

Plant Physiol.

150

1174-1191

2009

-

1

-

1

-

1

-

1

-

1

-

6

-

1

-

1

-

1

-

1

-

1

-

6

-

1

-

684902

Filling

Role of short-chain hydroxyacy ...

Homo sapiens

Biochem. Biophys. Res. Commun.

368

6-11

2008

-

1

-

11

1

-

2

-

1

-

2

-

1

-

12

3

-

1

-

11

1

-

1

-

2

-

1

-

12

3

-

695470

Yang

Re: Hadh2 and 3-hydroxyacyl-Co ...

Mus musculus

Am. J. Physiol. Endocrinol. Metab.

295

E987-E987

2008

1

-

1

-

1

-

1

-

1

-

1

-

1

-

684609

Liu

Production and characterizatio ...

Pseudomonas putida, Pseudomonas putida KT2442

Appl. Microbiol. Biotechnol.

76

1153-1159

2007

-

1

-

2

-

12

-

4

-

1

-

1

-

1

-

2

-

4

-

685573

Liu

Formation of an enolate interm ...

Rattus norvegicus

Bioorg. Med. Chem. Lett.

17

3187-3190

2007

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

7

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

7

-

687573

Martens

Specificity in beta cell expre ...

Homo sapiens, Rattus norvegicus

J. Biol. Chem.

282

21134-21144

2007

-

2

-

3

-

1

2

-

4

-

3

-

4

1

-

2

-

2

-

2

-

3

-

1

2

-

3

-

4

1

-

673264

van Hove

The HADHSC gene encoding short ...

Homo sapiens

Diabetes

55

3193-3196

2006

-

1

-

3

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

673340

He

Roles of type 10 17beta-hydrox ...

Homo sapiens

Endocr. Metab. Immune Disord. Drug Targets

6

95-102

2006

-

2

-

4

-

2

-

7

-

7

-

1

-

1

-

2

-

4

-

7

-

7

-

672317

Puyaubert

Temporal gene expression of 3- ...

Brassica napus

Biochim. Biophys. Acta

1687

152-163

2005

-

1

-

2

-

1

2

-

4

-

4

-

2

1

-

1

-

2

-

4

-

2

-

7

-

2

-

2

-

673530

Yang

3-Hydroxyacyl-CoA dehydrogenas ...

Homo sapiens, Sus scrofa

FEBS J.

272

4874-4883

2005

-

1

-

2

-

1

-

3

-

1

-

1

-

4

2

-

2

-

1

-

2

-

2

-

1

-

1

-

4

2

-

674100

Yi

Direct evidence for the functi ...

Fusarium verticillioides, Fusarium verticillioides A0149

J. Agric. Food Chem.

53

5456-5460

2005

-

1

-

2

-

6

-

1

-

4

-

1

-

1

-

1

-

1

-

2

-

1

-

4

-

1

-

1

-

657276

Liu

Expression and purification of ...

Rattus norvegicus

Protein Expr. Purif.

37

344-351

2004

-

1

-

3

-

4

2

-

1

-

4

-

1

-

2

-

4

1

-

2

-

1

2

-

3

-

4

2

-

1

-

1

-

2

-

4

1

-

657049

Winkler

A new type of a multifunctiona ...

Euglena gracilis 1224-5/25, Euglena gracilis

Plant Physiol.

131

753-762

2003

-

1

-

5

2

-

3

-

1

-

1

-

4

2

-

1

-

1

-

5

2

-

1

-

1

-

4

2

-

1

-

286588

Barycki

Biochemical characterization a ...

Homo sapiens

Biochemistry

38

5786-5789

1999

-

1

-

4

1

-

1

-

3

-

2

1

-

1

-

4

-

1

-

1

-

4

1

-

1

-

2

1

-

1

-

4

-

286589

He

Human brain short chain L-3-hy ...

Homo sapiens

J. Biol. Chem.

274

15014-15019

1999

-

6

2

-

2

-

2

-

2

5

-

7

-

3

2

-

1

-

1

-

6

2

-

2

-

2

5

-

7

-

3

2

-

286590

He

Molecular cloning, expression ...

Sus scrofa

Biochim. Biophys. Acta

1392

119-126

1998

-

1

-

2

1

-

2

1

-

3

-

1

-

2

1

-

3

1

-

3

-

1

-

1

-

2

1

-

2

1

-

1

-

2

1

-

3

1

-

3

-

286591

He

a human brain L-3-hydroxyacyl- ...

Homo sapiens

J. Biol. Chem.

273

10741-10746

1998

-

1

-

2

-

2

1

-

3

-

1

-

2

1

-

3

1

-

3

-

1

-

1

-

2

-

2

1

-

1

-

2

1

-

3

1

-

3

-

33732

Qin

Peroxisomal multifunctional en ...

Rattus norvegicus

Biochem. J.

321

21-28

1997

-

1

-

2

-

2

-

2

-

2

-

286592

Vredendaal

Human short-chain L-3-hydroxya ...

Homo sapiens

Biochem. Biophys. Res. Commun.

223

718-723

1996

-

1

-

3

-

5

-

1

-

1

-

1

-

1

-

5

-

1

-

2220

Thieringer

The beta-oxidation system in c ...

Neurospora crassa

J. Biol. Chem.

266

13110-13117

1991

-

2

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

286593

Hartmann

Spatial arrangement of coenzym ...

Sus scrofa

Biochemistry

30

2782-2790

1991

-

3

-

1

-

1

-

6

-

1

-

1

-

3

-

1

-

6

-

690046

Hiltunen

Peroxisomes and beta-oxidation ...

Rattus norvegicus

Scand. J. Clin. Lab. Invest. Suppl.

204

33-46

1991

-

1

-

1

-

1

-

1

-

1

-

286594

Birktoft

Structure of L-3-hydroxyacyl-c ...

Sus scrofa

Proc. Natl. Acad. Sci. USA

84

8262-8266

1987

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

33713

Sumegi

Binding of the enzymes of fatt ...

Sus scrofa

J. Biol. Chem.

259

8748-8752

1984

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286596

Holden

L-3-hydroxyacyl coenzyme a deh ...

Sus scrofa

J. Biol. Chem.

258

2383-2389

1983

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286269

El-Fakhri

The existence of an inner-memb ...

Rattus norvegicus

Biochim. Biophys. Acta

713

270-279

1982

-

1

-

1

-

1

-

4

7

-

2

-

1

-

1

-

1

-

1

-

4

7

-

2

-

2207

Pawar

The structure of the multienzy ...

Escherichia coli

J. Biol. Chem.

256

3894-3899

1981

-

3

2

-

1

-

1

-

2

1

-

1

-

1

-

3

2

-

1

-

2

1

-

2962

Binstock

Fatty acid oxidation complex f ...

Escherichia coli

Methods Enzymol.

71

403-411

1981

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286598

Holden

Differences in the binding of ...

Sus scrofa

FEBS Lett.

132

15-18

1981

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286601

Osumi

Purification and properties of ...

Rattus norvegicus

Arch. Biochem. Biophys.

203

372-383

1980

-

10

4

-

4

1

-

2

-

1

-

2

1

6

2

-

4

-

2

-

2

-

10

4

-

4

1

-

1

-

2

1

6

2

-

4

-

286602

Shimakata

Purification and characterizat ...

Mycobacterium smegmatis

J. Biochem.

86

1191-1198

1979

-

1

5

-

1

-

3

-

1

-

1

-

4

-

2

-

2

-

2

-

1

-

5

-

1

-

1

-

1

-

4

-

2

-

286603

El-Fakhri

The existence of two different ...

Rattus norvegicus

Biochem. Soc. Trans.

7

392-393

1979

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286604

Middleton

3-Oxoacyl-coenzyme A thiolases ...

Rattus norvegicus

Biochem. Soc. Trans.

6

80-83

1978

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286606

Bradshaw

L-3-hydroxylacyl coenzyme A de ...

Sus scrofa

Methods Enzymol.

35

122-128

1975

-

1

-

6

3

1

-

1

-

2

-

1

-

1

2

1

3

1

-

1

-

1

-

6

-

3

1

-

1

-

1

2

1

3

1

-

286052

Hillmer

-

Solubilization and partial cha ...

Clostridium kluyveri

Biochim. Biophys. Acta

334

12-23

1974

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286607

Noyes

Structural and functional simi ...

Sus scrofa

Proc. Natl. Acad. Sci. USA

71

1334-1338

1974

-

1

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

1

-

1

-

1

-

286608

Wininger

L-3-Hydroxacyl coenzyme A dehy ...

Sus scrofa

J. Mol. Biol.

90

409-413

1974

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

286609

Noyes

L-3-Hydroxyacyl coenzyme A deh ...

Sus scrofa

J. Biol. Chem.

248

3052-3059

1973

-

3

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

3

-

1

-

1

-

1

-

3

-

286610

Noyes

-

L-3-Hydroxyacyl coenzyme A deh ...

Sus scrofa

J. Biol. Chem.

248

3060-3066

1973

-

2

1

-

1

-

1

-

1

-

1

-

1

-

2

1

-

1

-

1

-

286611

Stern

Crystalline beta-hydroxybutyry ...

Sus scrofa

Biochim. Biophys. Acta

26

448-449

1957

-

1

-

1

-

1

-

6

-

2

-

1

-

1

-

1

-

1

-

6

-

2

-

286612

Wakil

Studies on the fatty acid oxid ...

Bos taurus

J. Biol. Chem.

207

631-638

1954

-

4

1

-

1

-

1

-

1

-

5

-

1

-

1

-

1

-

4

1

-

1

-

1

-

5

-

1

-

Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids

Data extracted from this reference: