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Literature summary for 1.1.1.331 extracted from

  • Shiraishi, A.; Murata, J.; Matsumoto, E.; Matsubara, S.; Ono, E.; Satake, H.
    De novo transcriptomes of Forsythia koreana using a novel assembly method insight into tissue- and species-specific expression of lignan biosynthesis-related gene (2016), PLoS ONE, 11, e0164805 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene FkSIRD, DNA and amino acid sequence determination and analysis from Forsythia genome, phylogenetic analysis, quantitative RT-PCR enzyme expression analysis Forsythia koreana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(-)-secoisolariciresinol + 2 NAD+ Forsythia koreana
-
(-)-matairesinol + 2 NADH + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Forsythia koreana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
callus high expression level of FkSIRD Forsythia koreana
-
leaf
-
Forsythia koreana
-
additional information tissue- and species-specific expression of the lignan biosynthesis-related gene FkSIRD, transcriptome analysis, overview. The expression levels of DIR, PLR, SIRD, and MOMT are 40fold, 5fold, 50fold, and 2fold higher in callus than in leaf, respectively Forsythia koreana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(-)-secoisolariciresinol + 2 NAD+
-
Forsythia koreana (-)-matairesinol + 2 NADH + 2 H+
-
?

Synonyms

Synonyms Comment Organism
FkSIRD
-
Forsythia koreana
matairesinol biosynthetic enzyme
-
Forsythia koreana
secoisolariciresinol dehydrogenase
-
Forsythia koreana
SirD
-
Forsythia koreana

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Forsythia koreana

Expression

Organism Comment Expression
Forsythia koreana all of the enzymes responsible for the biosynthesis of lignan aglycones, also SIRD, are upregulated in callus up

General Information

General Information Comment Organism
evolution molecular phylogenetic analysis of specialized metabolic enzyme genes from lignan-producing plants, two common gene clusters include genes from various plants and plant lineage-specific gene clusters. The specialized metabolic enzyme genes from lignan-producing plants include enzymes involved in the early common lignan biosynthesis upstream of matairesinol such as PLR and SIRD, suggesting that they have occurred in their ancestral plants and conserved their biological functions Forsythia koreana
metabolism the enzyme is involved in the lignan biosynthesis pathway, overview Forsythia koreana
physiological function matairesinol biosynthesis is prominently enhanced and matairesinol is highly accumulated in callus Forsythia koreana