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Literature summary for 1.1.1.300 extracted from
- Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma (2007), Int. J. Cancer, 120, 1618-1626.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in native, soluble form in Escherichia coli BL21-AI and as GFP-fusion protein in HeLa-cells | Homo sapiens |
| GFP-fusion protein in HeLa-cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | not detected in the peroxisome | Homo sapiens | - |
- |
| peroxisome | - |
Homo sapiens | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 23917 | - |
x * 23917, calculated from the deduced amino acid sequence | Homo sapiens |
| 27572 | - |
x * 27572, calculated from the deduced amino acid sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| retinol + NADP+ | Homo sapiens | important for the maintenance of retinoid homeostasis | retinal + NADPH + H+ | - |
r |  |
| retinol + NADP+ | Homo sapiens | important for the maintenance of retinoid homeostasis, low activity of the NRDRB1 splice variant possibly contributes to a disturbed retinoid homeostasis leading to abnormal differentiation and high susceptibility to human papilloma virus in the cervical epithelium | retinal + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9BTZ2 | - |
- |
| Homo sapiens | Q9BTZ2 | isoform 6, from full length cDNA, isoform of NRDR without residues 1-203; alternatively spliced variant NRDRA1 with a complete deletion of exons 3-6 | - |
| Homo sapiens | Q9BTZ2 | isoform 4, from full length cDNA, isoform of NRDR without residues 85-118; alternatively spliced variant NRDRB1 with a complete deletion of exon 3, activity of NRDRB1 much lower than activity of NRDR in forward and reverse reaction | - |
| Homo sapiens | Q9BTZ2 | isoform 5, from full length cDNA, isoform of NRDR without residues 85-118 and 160-204; alternatively spliced variant NRDRB2 with a complete deletion of exons 3 and 6 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant protein from Escherichia coli | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cervix | detected in 54% of cervical tumor tissue samples but not in normal cervical tissue | Homo sapiens | - |
| cervix | detected in cervical tumor tissue samples where NRDRB1 could not be detected | Homo sapiens | - |
| cervix | normal and neoplastic cervical tissue samples | Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| retinol + NADP+ | important for the maintenance of retinoid homeostasis | Homo sapiens | retinal + NADPH + H+ | - |
r | |
| retinol + NADP+ | important for the maintenance of retinoid homeostasis, low activity of the NRDRB1 splice variant possibly contributes to a disturbed retinoid homeostasis leading to abnormal differentiation and high susceptibility to human papilloma virus in the cervical epithelium | Homo sapiens | retinal + NADPH + H+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 23917, calculated from the deduced amino acid sequence | Homo sapiens |
| ? | x * 27572, calculated from the deduced amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | enzyme additionally displays high aldehyde reductase activity in retinoic acid metabolism | Homo sapiens |
| NADP(H)-dependent retinol dehydrogenase/reductase | - |
Homo sapiens |
| NRDR | - |
Homo sapiens |
| NRDRA1 | alternatively spliced variant with a complete deletion of exons 3-6 | Homo sapiens |
| NRDRB1 | alternatively spliced variant with a complete deletion of exon 3 | Homo sapiens |
| NRDRB2 | alternatively spliced variant with a complete deletion of exons 3 and 6 | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | calculated from the deduced amino acid sequence | - |
7.67 |
| Homo sapiens | calculated from the deduced amino acid sequence | - |
9.32 |
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Release 2023.1 (January 2023)
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