KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | dissociation constants for the cofactors and reaction kinetics at different physiological states in liver and brain | Jaculus orientalis | |
0.058 | - |
NADH | euthermic state, brain | Jaculus orientalis | |
0.074 | - |
NADH | euthermic state, liver | Jaculus orientalis | |
0.146 | - |
acetoacetate | euthermic state, brain | Jaculus orientalis | |
0.15 | - |
acetoacetate | euthermic state, liver | Jaculus orientalis | |
0.238 | - |
NAD+ | euthermic state, liver | Jaculus orientalis | |
0.633 | - |
(R)-3-hydroxybutyrate | euthermic state, liver | Jaculus orientalis | |
1.187 | - |
NAD+ | euthermic state, brain | Jaculus orientalis | |
2 | - |
(R)-3-hydroxybutyrate | euthermic state, brain | Jaculus orientalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Jaculus orientalis | 16020 | - |
mitochondrion | - |
Jaculus orientalis | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-3-hydroxybutyrate + NAD+ | Jaculus orientalis | during hibernation, the enzyme is responsible for bioconvertion of high amounts of ketone bodies, i.e. acetoacetate and (R)-3-hydroxybutyrate, in the liver for usage as energetic fuel | acetoacetate + NADH + H+ | - |
r | |
additional information | Jaculus orientalis | enzyme activity is differently regulated in liver and brain at euthermic, prehibernating,and hibernating state | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Jaculus orientalis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Jaculus orientalis | - |
liver | high activity | Jaculus orientalis | - |
additional information | during the cold adaptation process, the prehibernating stage, the enzyme activity is decreased compared to euthermic state, in the hibernation state, the rate of acetoacetate reduction is increased in liver, while the oxidation of D-beta-hydroxybutyrate is increased in brain | Jaculus orientalis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-3-hydroxybutyrate + NAD+ | - |
Jaculus orientalis | acetoacetate + NADH + H+ | - |
r | |
(R)-3-hydroxybutyrate + NAD+ | during hibernation, the enzyme is responsible for bioconvertion of high amounts of ketone bodies, i.e. acetoacetate and (R)-3-hydroxybutyrate, in the liver for usage as energetic fuel | Jaculus orientalis | acetoacetate + NADH + H+ | - |
r | |
additional information | enzyme activity is differently regulated in liver and brain at euthermic, prehibernating,and hibernating state | Jaculus orientalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BDH | - |
Jaculus orientalis |
D-beta-hydroxybutyrate dehydrogenase | - |
Jaculus orientalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Jaculus orientalis |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
9 | 37 | - |
Jaculus orientalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Jaculus orientalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Jaculus orientalis | |
NADH | - |
Jaculus orientalis |