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Literature summary for 1.1.1.30 extracted from

  • Kluger, R.; Nakaoka, K.; Tsui, W.C.
    Substrate analogue studies of the specificity and catalytic mechanism of D-3-hydroxybutyrate dehydrogenase (1978), J. Am. Chem. Soc., 100, 7388-7392.
No PubMed abstract available
Search for more literature for 1.1.1.30

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine
-
 Paucimonas lemoignei

Inhibitors

Inhibitors Comment Organism Structure
acetylphosphonate 16.7 mM, pH 7, 28% inhibition Paucimonas lemoignei
dimethyl phosphate 16.7 mM, pH 7, 12% inhibition Paucimonas lemoignei
methanephosphonic acid 3.3 mM, pH 7, 11% inhibition Paucimonas lemoignei
methyl methylphosphonate 3.3 mM, pH 7, 13% inhibition Paucimonas lemoignei
methyl phosphate 16.7 mM, pH 7, 21% inhibition Paucimonas lemoignei
oxalate 16.7 mM, pH 7, 9% inhibition Paucimonas lemoignei
pyruvate 16.7 mM, pH 7.0, 22% inhibition Paucimonas lemoignei
sodium acetonylphosphonate 3.3 mM, pH 7, 21% inhibition Paucimonas lemoignei
sodium monomethyl acetylphosphonate 16.7 mM, pH 7, 60% inhibition Paucimonas lemoignei
sodium monomethylacetonylphosphate 16.7 mM, pH 7, 30% inhibition Paucimonas lemoignei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Paucimonas lemoignei
-
 acetoacetate + NADH
-
 r

Organism

Organism UniProt Comment Textmining
Paucimonas lemoignei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
 Paucimonas lemoignei acetoacetate + NADH
-
 r
2-hydroxypropansulfonate + NAD+
-
 Paucimonas lemoignei acetonylsulfonate + NADH
-
 r
2-methyl-3-hydroxybutyrate + NAD+
-
 Paucimonas lemoignei 2-methylacetoacetate + NADH
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5 reduction of acetoacetate Paucimonas lemoignei

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Paucimonas lemoignei