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Literature summary for 1.1.1.30 extracted from

  • Phelps, D.C.; Hatefi, Y.
    Inhibition of D(-)-beta-hydroxybutyrate dehydrogenase by modifiers of disulfides, thiols, and vicinal dithiols (1981), Biochemistry, 20, 453-458.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
diazenedicarboxylic acid bis(dimethylamide) NAD+ protects against inhibition Bos taurus
N-ethylmaleimide NAD+ protects against inhibition Bos taurus
p-chloromercuribenzoate 0.001 mM, extremely rapid inhibition, NAD+ and NADH protect against inhibition Bos taurus
Phenylarsine oxide NAD+ and NADH protect against inhibition Bos taurus
Sodium sulfide competitive vs. beta-hydroxybutyrate Bos taurus
sodium sulfite uncompetitive vs. NAD+ and acetoacetate, competitive vs. beta-hydroxybutyrate Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
NADH
-
Bos taurus
0.175
-
NAD+
-
Bos taurus
0.26
-
acetoacetate
-
Bos taurus
0.8
-
(R)-3-hydroxybutanoate
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+ Bos taurus
-
acetoacetate + NADH
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-hydroxybutanoate + NAD+
-
Bos taurus acetoacetate + NADH
-
r
(R)-3-hydroxybutanoate + NAD+
-
Bos taurus acetoacetate + NADH + H+
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bos taurus