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Literature summary for 1.1.1.30 extracted from
- Comparison of 3-hydroxybutyrate dehydrogenase from bovine heart and rat liver mitochondria (1988), Arch. Biochem. Biophys., 262, 85-98.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphatidylcholine | - |
Rattus norvegicus |  |
| phosphatidylcholine | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.24 | - |
NAD+ | liver 3-hydroxybutyrate dehydrogenase | Rattus norvegicus | |
| 0.36 | - |
NAD+ | heart 3-hydroxybutyrate dehydrogenase | Bos taurus | |
| 1.05 | - |
(R)-3-hydroxybutanoate | heart 3-hydroxybutyrate dehydrogenase | Bos taurus | |
| 1.32 | - |
(R)-3-hydroxybutanoate | liver 3-hydroxybutyrate dehydrogenase | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27000 | - |
alpha4, 4 * 27000, sedimentation equilibrium | Rattus norvegicus |
| 27000 | - |
alpha4, 4 * 27000, sedimentation equilibrium | Bos taurus |
| 31000 | - |
alpha4, 4 * 31000, SDS-PAGE | Rattus norvegicus |
| 31000 | - |
alpha4, 4 * 31000, SDS-PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-3-hydroxybutanoate + NAD+ | Rattus norvegicus | - |
acetoacetate + NADH | - |
r | |
| (R)-3-hydroxybutanoate + NAD+ | Bos taurus | - |
acetoacetate + NADH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| phospholipase A2 treatment, controlled-pore glass beads | Rattus norvegicus |
| phospholipase A2 treatment, controlled-pore glass beads | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| heart | - |
Bos taurus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 91 | - |
liver 3-hydroxybutyrate dehydrogenase, reconstituted with mitochondrial phospholipids | Rattus norvegicus |
| 145 | - |
heart 3-hydroxybutyrate dehydrogenase, reconstituted with mitochondrial phospholipids | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-3-hydroxybutanoate + NAD+ | - |
Rattus norvegicus | acetoacetate + NADH | - |
r | |
| (R)-3-hydroxybutanoate + NAD+ | - |
Bos taurus | acetoacetate + NADH | - |
r | |
| (R)-3-hydroxybutanoate + NAD+ | - |
Rattus norvegicus | acetoacetate + NADH + H+ | - |
r | |
| (R)-3-hydroxybutanoate + NAD+ | - |
Bos taurus | acetoacetate + NADH + H+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | alpha4, 4 * 27000, sedimentation equilibrium | Rattus norvegicus |
| tetramer | alpha4, 4 * 27000, sedimentation equilibrium | Bos taurus |
| tetramer | alpha4, 4 * 31000, SDS-PAGE | Rattus norvegicus |
| tetramer | alpha4, 4 * 31000, SDS-PAGE | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
| NAD+ | - |
Bos taurus | |
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