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Literature summary for 1.1.1.298 extracted from
- Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation (2002), J. Bacteriol., 184, 2404-2410.
General Stability
| General Stability | Organism |
|---|---|
| enzyme is oxygen insensitive but sensitive to repeated freezing and thawing | Chloroflexus aurantiacus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | 90% inhibition | Chloroflexus aurantiacus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | stimulation | Chloroflexus aurantiacus | |
| Fe2+ | stimulation | Chloroflexus aurantiacus | |
| Mg2+ | stimulation | Chloroflexus aurantiacus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 145000 | - |
2 * 145000, SDS-PAGE | Chloroflexus aurantiacus |
| 300000 | - |
gel filtration | Chloroflexus aurantiacus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chloroflexus aurantiacus | - |
bifunctional enzyme which catalyzes the two-step reduction from malonyl-CoA to malonate semialdehyde and from malonate semialdehyde to 3-hydroxypropionate | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Chloroflexus aurantiacus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, presence of 10% (vol/vol) glycerol, stable for weeks | Chloroflexus aurantiacus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | bifunctional enzyme which catalyzes the two-step reduction from malonyl-CoA to malonate semialdehyde and from malonate semialdehyde to 3-hydroxypropionate | Chloroflexus aurantiacus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 145000, SDS-PAGE | Chloroflexus aurantiacus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| malonyl-CoA reductase | - |
Chloroflexus aurantiacus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Chloroflexus aurantiacus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8.5 | more than 50% of maximla acitivty within | Chloroflexus aurantiacus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no cofactor: NADH | Chloroflexus aurantiacus | |
| NADPH | - |
Chloroflexus aurantiacus | |
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Release 2023.1 (January 2023)
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