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Literature summary for 1.1.1.290 extracted from

  • Sato, K.; Yoshiga, T.; Hasegawa, K.
    Involvement of vitamin B6 biosynthesis pathways in the insecticidal activity of Photorhabdus luminescens (2016), Appl. Environ. Microbiol., 82, 3546-3553.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Photorhabdus luminescens Q7N2B2
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Photorhabdus luminescens DSM 15139 Q7N2B2
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Synonyms

Synonyms Comment Organism
erythronate-4-phosphate dehydrogenase
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Photorhabdus luminescens
PDXB
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Photorhabdus luminescens

General Information

General Information Comment Organism
physiological function the pdxB gene, encoding erythronate-4-phosphate dehydrogenase, is required for de novo vitamin B6 biosynthesis. Mutation in pdxB causes growth deficiency of Photorhabdus luminescens in nutrient-poor medium, which is restored under nutrient-rich conditions or by supplementation with pyridoxal 5'-phosphate. Supplementation with pyridoxal, pyridoxine, and pyridoxamine also restores the growth of the pdxB mutant. Supplementation with pyridoxal 5'-phosphate restores the virulence-deficient phenotype against Caenorhabditis elegans Photorhabdus luminescens