Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.286 extracted from

  • Lin, Y.; West, A.H.; Cook, P.F.
    Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae (2008), Biochemistry, 47, 10809-10815.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.286

Inhibitors

Inhibitors Comment Organism Structure
3-carboxypropylidenemalate
-
 Saccharomyces cerevisiae
Cl-
-
 Saccharomyces cerevisiae
NADH product inhibitor Saccharomyces cerevisiae
potassium acetate
-
 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
K+ best activator, 200 mM activates by 100%, increases the affinity of enzyme for NAD+ at high pH Saccharomyces cerevisiae
additional information 200 mM Cs+, Li+, and Na+ do not activate Saccharomyces cerevisiae
NH4+ 200 mM activates by 80.9% Saccharomyces cerevisiae
Rb+ 200 mM activates by 29.3% Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
homoisocitrate + NAD+ Saccharomyces cerevisiae
-
 ? + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
homoisocitrate + NAD+
-
 Saccharomyces cerevisiae ? + NADH
-
 ?
isocitrate + NAD+ slow substrate Saccharomyces cerevisiae 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
HICDH
-
 Saccharomyces cerevisiae
homoisocitrate dehydrogenase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7
-
 NADH
-
 Saccharomyces cerevisiae
90
-
 Cl-
-
 Saccharomyces cerevisiae
500
-
 potassium acetate
-
 Saccharomyces cerevisiae