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Literature summary for 1.1.1.284 extracted from
- Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila (2011), Nitric Oxide, 24, 17-24.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of the fdh in the central nervous system of transgenic Drosophila melanogaster | Drosophila melanogaster |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | overexpression of the fdh in the central nervous system significantly increases GSNOR activity and induces visual pattern memory defects of Drosophila melanogaster, Overexpression of fdh results in NO imbalance, thereby affecting the NO-cGMPPKG pathway and protein S-nitrosation and, ultimately, learning and memory function, regulation of protein S-nitrosation by fdh in transgenic flies, overview. elav-Gal4 driven pan-neuronal GSNOR and PKG co-expression flies restore normal memory performance completely | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-nitrosoglutathione + NADH | Drosophila melanogaster | - |
? + NAD+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
gene fdh | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | GSNOR is the sole alcohol dehydrogenase isozyme in vertebrate brains | Drosophila melanogaster | - |
| neuron | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-nitrosoglutathione + NADH | - |
Drosophila melanogaster | ? + NAD+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FDH | - |
Drosophila melanogaster |
| formaldehyde dehydrogenase | - |
Drosophila melanogaster |
| GSNOR | - |
Drosophila melanogaster |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Drosophila melanogaster |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Drosophila melanogaster | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | overexpression of the fdh in the central nervous system significantly increases GSNOR activity and induces visual pattern memory defects of Drosophila melanogaster. Overexpression of the fdh in the fan-shaped body induces memory defect, while overexpression in the mushroom body does not. The visual pattern memory defect can be rescued by co-expression with exogenous cGMP-dependent protein kinase | Drosophila melanogaster |
| physiological function | the enzyme controls the nitric oxide metabolism, which plays a crucial role in visual pattern memory in Drosophila melanogaster. The role of fdh in learning and memory is independent of development and is neuron-specific | Drosophila melanogaster |
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