Cloned (Comment) | Organism |
---|---|
gene adhC, encoded in the adhC-estD operon, expression of the adhC-estD operon is regulated by NmlRHI in strain Rd KW20, the Neisseria MerR-like regulator, overview. The NmlRHI-AdhC system in the genome sequences of nontypeable Haemophilus influenzae strains R2846, R2866, and 86-028NP shows variations, the adhC gene of strain 86-028NP is nonfunctional due to a premature stop codon, polymorphisms in the operator/promoter region of strain R2866 result in reduced enzyme activity, genotyping of clinical isolates, in silico promoter analysis, overview | Haemophilus influenzae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | chromosomal inactivation of either adhC or nmlRHI resulted in sensitivity to S-nitrosoglutathione and decreased S-nitrosoglutathione reductase activity, the NmlRHI-AdhC system in the genome sequences of nontypeable Haemophilus influenzae strains R2846, R2866, and 86-028NP shows variations, the adhC gene of strain 86-028NP is nonfunctional due to a premature stop codon, polymorphisms in the operator/promoter region of strain R2866 result in reduced enzyme activity, genotyping of clinical isolates, overview | Haemophilus influenzae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Haemophilus influenzae | genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview | ? | - |
? | |
additional information | Haemophilus influenzae KW20 | genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | A5HES9 | strain Rd KW20, gene adhC | - |
Haemophilus influenzae KW20 | A5HES9 | strain Rd KW20, gene adhC | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview | Haemophilus influenzae | ? | - |
? | |
additional information | AdhC has NADH-dependent S-nitrosoglutathione reductase activity | Haemophilus influenzae | ? | - |
? | |
additional information | genes adhC and nmlRHI are required for defense against S-nitrosoglutathione in the organism, regulation of the adhC-estD operon, overview | Haemophilus influenzae KW20 | ? | - |
? | |
additional information | AdhC has NADH-dependent S-nitrosoglutathione reductase activity | Haemophilus influenzae KW20 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AdhC | - |
Haemophilus influenzae |
class III alcohol dehydrogenase | - |
Haemophilus influenzae |
glutathione-dependent alcohol dehydrogenase | - |
Haemophilus influenzae |
GSNO reductase | - |
Haemophilus influenzae |
NADH-GSNO oxidoreductase | - |
Haemophilus influenzae |
S-nitrosoglutathione reductase | - |
Haemophilus influenzae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | dependent on | Haemophilus influenzae |