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Literature summary for 1.1.1.284 extracted from

  • Fernandez, M.R.; Biosca, J.A.; Martinez, M.C.; Achkor, H.; Farres, J.; Pares, X.
    Formaldehyde dehydrogenase from yeast and plant: implications for the general functional and structural significance of class III alcohol dehydrogenase (1997), Adv. Exp. Med. Biol., 414, 373-381.
    View publication on PubMed
Search for more literature for 1.1.1.284

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
 S-hydroxymethyl glutathione
-
 Homo sapiens
0.00092
-
 S-hydroxymethyl glutathione
-
 Rattus norvegicus
0.002
-
 S-hydroxymethyl glutathione
-
 Pisum sativum
0.006
-
 S-hydroxymethyl glutathione
-
 Drosophila melanogaster
0.0065
-
 NAD+ reaction with S-hydroxymethyl glutathione Pisum sativum
0.04
-
 S-hydroxymethyl glutathione
-
 Saccharomyces cerevisiae
0.094
-
 S-hydroxymethyl glutathione
-
 Escherichia coli
0.14
-
 NAD+ reaction with S-hydroxymethyl glutathione Pisum sativum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formaldehyde + glutathione + NAD+ Escherichia coli
-
 S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ Saccharomyces cerevisiae main enzymatic system responsible for the formaldehyde elimination S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ Pisum sativum main enzymatic system responsible for the formaldehyde elimination S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ Arabidopsis thaliana main enzymatic system responsible for the formaldehyde elimination S-formylglutathione + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Drosophila melanogaster
-
 alcohol dehydrogenase III
-
Escherichia coli
-
 alcohol dehydrogenase III
-
Homo sapiens
-
 class II alcohol dehydrogenase
-
Pisum sativum
-
 class III alcohol dehydrogenase
-
Rattus norvegicus
-
 class II alcohol dehydrogenase
-
Saccharomyces cerevisiae
-
 class III alcohol dehydrogenase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formaldehyde + glutathione + NAD+
-
 Drosophila melanogaster S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+
-
 Escherichia coli S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+
-
 Arabidopsis thaliana S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione Homo sapiens S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione Rattus norvegicus S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione Saccharomyces cerevisiae S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione Pisum sativum S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ main enzymatic system responsible for the formaldehyde elimination Saccharomyces cerevisiae S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ main enzymatic system responsible for the formaldehyde elimination Pisum sativum S-formylglutathione + NADH + H+
-
 ?
formaldehyde + glutathione + NAD+ main enzymatic system responsible for the formaldehyde elimination Arabidopsis thaliana S-formylglutathione + NADH + H+
-
 ?
formaldehyde + S-hydroxymethyl glutathione + NAD+
-
 Drosophila melanogaster ?
-
 ?
formaldehyde + S-hydroxymethyl glutathione + NAD+
-
 Escherichia coli ?
-
 ?
formaldehyde + S-hydroxymethyl glutathione + NAD+
-
 Homo sapiens ?
-
 ?
formaldehyde + S-hydroxymethyl glutathione + NAD+
-
 Rattus norvegicus ?
-
 ?
formaldehyde + S-hydroxymethyl glutathione + NAD+
-
 Saccharomyces cerevisiae ?
-
 ?
formaldehyde + S-hydroxymethyl glutathione + NAD+
-
 Pisum sativum ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.33
-
 S-hydroxymethyl glutathione
-
 Homo sapiens
3.6
-
 S-hydroxymethyl glutathione
-
 Rattus norvegicus
6.33
-
 S-hydroxymethyl glutathione
-
 Pisum sativum
16
-
 S-hydroxymethyl glutathione
-
 Drosophila melanogaster
88.3
-
 S-hydroxymethyl glutathione
-
 Saccharomyces cerevisiae
156
-
 S-hydroxymethyl glutathione
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Drosophila melanogaster
NAD+
-
 Escherichia coli
NAD+
-
 Homo sapiens
NAD+
-
 Rattus norvegicus
NAD+
-
 Saccharomyces cerevisiae
NAD+
-
 Pisum sativum
NAD+
-
 Arabidopsis thaliana